Murcko scaffold
Ring system with 3 rings and 19 atoms
82 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 19
- Chemicals
- 82
- With full pages
- 18
Scaffold SMILES
O=C(C=Cc1cccs1)Nc1nc2ccccc2s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 82 of 82 chemicals
![Methyl 2-((Z)-6-bromo-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate chemical structure, C17H13BrN2O3S2, CAS 865197-91-7](/s/AWSVXVFWIROOMC-UXSCQYIGSA-N.svg)
Methyl 2-((Z)-6-bromo-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate
CAS 865197-91-7C17H13BrN2O3S2
![Methyl 2-((Z)-6-(methylsulfonyl)-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate chemical structure, C18H16N2O5S3, CAS 865198-48-7](/s/XTAQUFITSWUZDO-MOCLJKNNSA-N.svg)
Methyl 2-((Z)-6-(methylsulfonyl)-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate
CAS 865198-48-7C18H16N2O5S3
![Ethyl 2-((Z)-6-bromo-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate chemical structure, C18H15BrN2O3S2, CAS 865247-11-6](/s/GZCZZOKXFURVHR-CNJWNYHPSA-N.svg)
Ethyl 2-((Z)-6-bromo-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)benzo[d]thiazol-3(2H)-yl)acetate
CAS 865247-11-6C18H15BrN2O3S2
![(2E,NZ)-N-(6-bromo-3-(2-ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-3-(thiophen-2-yl)acrylamide chemical structure, C18H17BrN2O2S2, CAS 865162-79-4](/s/UGKPVPJVKRLDFL-CNJWNYHPSA-N.svg)
(2E,NZ)-N-(6-bromo-3-(2-ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-3-(thiophen-2-yl)acrylamide
CAS 865162-79-4C18H17BrN2O2S2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3OS2, CAS 1052539-02-2](/s/BQKVTQQDSDSHSE-BXTVWIJMSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052539-02-2C19H22ClN3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C18H19ClFN3OS2, CAS 1052529-30-2](/s/MOTPDNRIQHSGRW-WVLIHFOGSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052529-30-2C18H19ClFN3OS2
![(E)-N-(4,6-Difluorobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C18H18ClF2N3OS2, CAS 1052529-65-3](/s/UPWRACXDBZZPNX-IPZCTEOASA-N.svg)
(E)-N-(4,6-Difluorobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052529-65-3C18H18ClF2N3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3OS2, CAS 1052541-77-1](/s/FIIMXMMLCJGEFC-RRABGKBLSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052541-77-1C19H22ClN3OS2
![(E)-N-(3-(Dimethylamino)propyl)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H21ClFN3OS2, CAS 1052533-83-1](/s/LWCIFKGKGNFGCE-BXTVWIJMSA-N.svg)
(E)-N-(3-(Dimethylamino)propyl)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052533-83-1C19H21ClFN3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(5-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3O2S2, CAS 1052530-81-0](/s/DIOHILNSWLBSTO-BXTVWIJMSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(5-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052530-81-0C19H22ClN3O2S2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3O2S2, CAS 1052531-28-8](/s/KJXHKRHIFNEKCK-RRABGKBLSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052531-28-8C19H22ClN3O2S2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3O2S2, CAS 1052531-75-5](/s/YYXSABAQMIJUED-BXTVWIJMSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052531-75-5C19H22ClN3O2S2
![(E)-N-(3-(Dimethylamino)propyl)-N-(4-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H21ClFN3OS2, CAS 1052546-45-8](/s/IMOKPGFFCXWBST-RRABGKBLSA-N.svg)
(E)-N-(3-(Dimethylamino)propyl)-N-(4-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1052546-45-8C19H21ClFN3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(4-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C18H19ClFN3OS2, CAS 1217230-78-8](/s/WEVJWKBVBHULEY-HRNDJLQDSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(4-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1217230-78-8C18H19ClFN3OS2
![(E)-N-(6-Chlorobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C18H19Cl2N3OS2, CAS 1322195-30-1](/s/XEYZTWRPOSDENO-WVLIHFOGSA-N.svg)
(E)-N-(6-Chlorobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1322195-30-1C18H19Cl2N3OS2
![(E)-N-(6-Bromobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C18H19BrClN3OS2, CAS 1177812-03-1](/s/MXRYKIKBJKHZGW-WVLIHFOGSA-N.svg)
(E)-N-(6-Bromobenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1177812-03-1C18H19BrClN3OS2
![(E)-N-(3-(Dimethylamino)propyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylamide hydrochloride chemical structure, C21H25ClN4O4S2, CAS 1321970-17-5](/s/DYMCNGUAIGAUIE-HCUGZAAXSA-N.svg)
(E)-N-(3-(Dimethylamino)propyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylamide hydrochloride
CAS 1321970-17-5C21H25ClN4O4S2
![(E)-N-(Benzo[d]thiazol-2-yl)-N-(3-(dimethylamino)propyl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3OS2, CAS 1217227-10-5](/s/KUFUBSXINRCGHA-ASTDGNLGSA-N.svg)
(E)-N-(Benzo[d]thiazol-2-yl)-N-(3-(dimethylamino)propyl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1217227-10-5C19H22ClN3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C19H22ClN3O3S3, CAS 1217219-54-9](/s/ILNKIJFHTCBZFA-MLBSPLJJSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1217219-54-9C19H22ClN3O3S3
![(E)-N-(2-(Dimethylamino)ethyl)-N-(4-ethoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C20H24ClN3O2S2, CAS 1135224-57-5](/s/BKYMQNABYHIISD-ASTDGNLGSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(4-ethoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1135224-57-5C20H24ClN3O2S2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C20H24ClN3O2S2, CAS 1135225-05-6](/s/HUCHJMXAAYSPJS-VRTOBVRTSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1135225-05-6C20H24ClN3O2S2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(6-ethylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C20H24ClN3OS2, CAS 1135225-14-7](/s/FHFTVUKEMKUFIU-VRTOBVRTSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(6-ethylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1135225-14-7C20H24ClN3OS2
![(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C20H24ClN3O2S2, CAS 1135225-42-1](/s/ZYOHYFABXGXHFS-VRTOBVRTSA-N.svg)
(E)-N-(2-(Dimethylamino)ethyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1135225-42-1C20H24ClN3O2S2
![(E)-N-(6-Chlorobenzo[d]thiazol-2-yl)-N-(2-(diethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride chemical structure, C20H23Cl2N3OS2, CAS 1135225-99-8](/s/KSDGWWOOCRGDLP-VRTOBVRTSA-N.svg)
(E)-N-(6-Chlorobenzo[d]thiazol-2-yl)-N-(2-(diethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride
CAS 1135225-99-8C20H23Cl2N3OS2
- (E)-N-(4,7-Dimethoxybenzo[d]thiazol-2-yl)-N-(2-(dimethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride1135226-41-3C20H24ClN3O3S2
- (E)-N-(2-(Diethylamino)ethyl)-N-(6-fluorobenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135226-75-3C20H23ClFN3OS2
- (E)-N-(2-(Diethylamino)ethyl)-N-(6-methoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135226-90-2C21H26ClN3O2S2
- (E)-N-(2-(Diethylamino)ethyl)-N-(6-methylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135225-70-5C21H26ClN3OS2
- (E)-N-(2-(Dimethylamino)ethyl)-N-(4,5-dimethylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135227-23-4C20H24ClN3OS2
- (E)-N-(2-(Diethylamino)ethyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135226-70-8C22H28ClN3O2S2
- (E)-N-(2-(Dimethylamino)ethyl)-N-(4,6-dimethylbenzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide hydrochloride1135227-70-1C20H24ClN3OS2
- (2E)-N-[(2Z)-4,6-Dichloro-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-3-(thiophen-2-yl)prop-2-enamide1007492-55-8C15H10Cl2N2OS2
- (E)-N-(6-(N,N-Dimethylsulfamoyl)benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylamide1005998-65-1C16H15N3O3S3
- (E)-N-(6-Bromobenzo[d]thiazol-2-yl)-N-(2-(diethylamino)ethyl)-3-(thiophen-2-yl)acrylamide hydrochloride1185243-17-7C20H23BrClN3OS2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(NCCc1nc2ccccc2[nH]1)c1ccco1](/scaffold/MUCXZDDNXLJEFN-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1nc2ccccc2[nH]1)c1ccco19 chemicals
O=S(=O)(NCCc1cn2ccccc2n1)c1cccs16 chemicals
O=C(CCN1C(=O)c2ccccc2C1=O)Nc1nncs15 chemicals![Scaffold O=C(CSc1nc2ccccc2[nH]1)Nc1nncs1](/scaffold/FLQNZEWXXIIPSB-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2ccccc2[nH]1)Nc1nncs14 chemicals![Scaffold O=C(NN=Cc1ccc[nH]1)c1cc2ccccc2s1](/scaffold/GXAIAQWVOOSMGP-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccc[nH]1)c1cc2ccccc2s13 chemicals
O=C(C=Cc1ccco1)Nc1nc2ccccc2s13 chemicals
O=C(NCCc1cn2ccccc2n1)c1ccco13 chemicals![Scaffold O=C(CSc1nc2ccccc2[nH]1)NC1CCCC1](/scaffold/OFZIZUMEEKHZKY-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2ccccc2[nH]1)NC1CCCC13 chemicals![Scaffold O=C(CSc1cn[nH]n1)Nc1nc2ccccc2s1](/scaffold/ZFKLDMPOYSULTN-UHFFFAOYSA-N/structure.svg)
O=C(CSc1cn[nH]n1)Nc1nc2ccccc2s13 chemicals
O=C(NN=Cc1ccco1)c1cc2ccccc2o12 chemicals
O=C(CSc1nc2ccccc2s1)Nc1nccs12 chemicals![Scaffold O=C(CSc1nc2ccccc2[nH]1)Nc1nccs1](/scaffold/AWKYUWAFZMNBCY-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2ccccc2[nH]1)Nc1nccs12 chemicals