Murcko scaffold
Ring system with 2 rings and 21 atoms
31 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 21
- Chemicals
- 31
- With full pages
- 4
Scaffold SMILES
O=C(CNS(=O)(=O)c1ccccc1)NCc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 31 of 31 chemicals
![N-Benzyl-N-methyl-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H22N2O3S, CAS 428833-12-9](/s/APGWJOZDCZWLQP-UHFFFAOYSA-N.svg)
N-Benzyl-N-methyl-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428833-12-9C18H22N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-[(4-methylphenyl)methyl]acetamide chemical structure, C17H20N2O3S, CAS 593262-09-0](/s/FBVFWSVBKWHSHN-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-[(4-methylphenyl)methyl]acetamide
CAS 593262-09-0C17H20N2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-[(4-methoxyphenyl)methyl]acetamide chemical structure, C17H20N2O4S, CAS 593262-11-4](/s/PQWMWGWPCGNRPL-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-[(4-methoxyphenyl)methyl]acetamide
CAS 593262-11-4C17H20N2O4S
![2-[Methyl-(4-methylphenyl)sulfonylamino]-N-[(4-methylphenyl)methyl]acetamide chemical structure, C18H22N2O3S, CAS 757218-05-6](/s/CMSZZWYCEWRTRG-UHFFFAOYSA-N.svg)
2-[Methyl-(4-methylphenyl)sulfonylamino]-N-[(4-methylphenyl)methyl]acetamide
CAS 757218-05-6C18H22N2O3S
N-Benzyl-2-(N,4-dimethylphenylsulfonamido)acetamide
CAS 522662-02-8C17H20N2O3S
![N-[(4-Fluorophenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C17H19FN2O3S, CAS 701246-27-7](/s/ATHQGJQLIOCSEB-UHFFFAOYSA-N.svg)
N-[(4-Fluorophenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 701246-27-7C17H19FN2O3S
![N-[(4-Methoxyphenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H22N2O4S, CAS 428837-11-0](/s/BSSWTXOBDQLKNM-UHFFFAOYSA-N.svg)
N-[(4-Methoxyphenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428837-11-0C18H22N2O4S
![N-[(4-Chlorophenyl)methyl]-2-[(2,5-dichlorophenyl)sulfonyl-methylamino]acetamide chemical structure, C16H15Cl3N2O3S, CAS 593264-58-5](/s/OYNDSEIQXZGQGQ-UHFFFAOYSA-N.svg)
N-[(4-Chlorophenyl)methyl]-2-[(2,5-dichlorophenyl)sulfonyl-methylamino]acetamide
CAS 593264-58-5C16H15Cl3N2O3S
![2-[(4-Methoxy-3-methylphenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide chemical structure, C19H24N2O5S, CAS 717830-64-3](/s/BSEDSXQOANCGJS-UHFFFAOYSA-N.svg)
2-[(4-Methoxy-3-methylphenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide
CAS 717830-64-3C19H24N2O5S
![2-[(3-Chloro-4-methoxyphenyl)sulfonyl-methylamino]-N-[(4-methylphenyl)methyl]acetamide chemical structure, C18H21ClN2O4S, CAS 714212-86-9](/s/NZKGLNMGNGZIEO-UHFFFAOYSA-N.svg)
2-[(3-Chloro-4-methoxyphenyl)sulfonyl-methylamino]-N-[(4-methylphenyl)methyl]acetamide
CAS 714212-86-9C18H21ClN2O4S
![2-[(4-Fluorophenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide chemical structure, C17H19FN2O4S, CAS 675861-36-6](/s/JTVNPMMZJMLWMO-UHFFFAOYSA-N.svg)
2-[(4-Fluorophenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide
CAS 675861-36-6C17H19FN2O4S
![2-[Benzenesulfonyl(methyl)amino]-N-[(4-chlorophenyl)methyl]acetamide chemical structure, C16H17ClN2O3S, CAS 593262-10-3](/s/CJQLMXRPSONEQD-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-[(4-chlorophenyl)methyl]acetamide
CAS 593262-10-3C16H17ClN2O3S
![N-Benzyl-2-[(4-chlorophenyl)sulfonyl-methylamino]-N-methylacetamide chemical structure, C17H19ClN2O3S, CAS 593245-04-6](/s/KUHKRAKDPLULPB-UHFFFAOYSA-N.svg)
N-Benzyl-2-[(4-chlorophenyl)sulfonyl-methylamino]-N-methylacetamide
CAS 593245-04-6C17H19ClN2O3S
![2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide chemical structure, C17H19ClN2O4S, CAS 593244-94-1](/s/DMJGDMATLSHDTB-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-[(4-methoxyphenyl)methyl]acetamide
CAS 593244-94-1C17H19ClN2O4S
![N-[(2-Chlorophenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C17H19ClN2O3S, CAS 428828-04-0](/s/KYJHJNMYARFRAV-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)methyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428828-04-0C17H19ClN2O3S
![N-[(2-Chlorophenyl)methyl]-2-[(4-chlorophenyl)sulfonyl-methylamino]acetamide chemical structure, C16H16Cl2N2O3S, CAS 499113-64-3](/s/JRMIPYZIORZCIH-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)methyl]-2-[(4-chlorophenyl)sulfonyl-methylamino]acetamide
CAS 499113-64-3C16H16Cl2N2O3S
![N-[(2-Chlorophenyl)methyl]-2-[(4-methoxy-3-methylphenyl)sulfonyl-methylamino]acetamide chemical structure, C18H21ClN2O4S, CAS 708285-43-2](/s/IBHHJEFACGLHJD-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)methyl]-2-[(4-methoxy-3-methylphenyl)sulfonyl-methylamino]acetamide
CAS 708285-43-2C18H21ClN2O4S
![N-Benzyl-N-tert-butyl-2-[(4-chlorophenyl)sulfonyl-methylamino]acetamide chemical structure, C20H25ClN2O3S, CAS 709009-39-2](/s/KWXZATZNMROJQR-UHFFFAOYSA-N.svg)
N-Benzyl-N-tert-butyl-2-[(4-chlorophenyl)sulfonyl-methylamino]acetamide
CAS 709009-39-2C20H25ClN2O3S
![2-[Ethyl-(4-methylphenyl)sulfonylamino]-N-[(2-methoxyphenyl)methyl]acetamide chemical structure, C19H24N2O4S, CAS 827005-79-8](/s/OCHMKZZSTXWGNG-UHFFFAOYSA-N.svg)
2-[Ethyl-(4-methylphenyl)sulfonylamino]-N-[(2-methoxyphenyl)methyl]acetamide
CAS 827005-79-8C19H24N2O4S
![N-[(2-Chlorophenyl)methyl]-2-[ethyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C18H21ClN2O3S, CAS 838843-33-7](/s/NFMPSHXFGHPDKR-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)methyl]-2-[ethyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 838843-33-7C18H21ClN2O3S
![2-[[[4-(Acetylamino)phenyl]sulfonyl]ethylamino]-N-[(4-chlorophenyl)methyl]acetamide chemical structure, C19H22ClN3O4S, CAS 852386-94-8](/s/BZPQWHHPIBCERL-UHFFFAOYSA-N.svg)
2-[[[4-(Acetylamino)phenyl]sulfonyl]ethylamino]-N-[(4-chlorophenyl)methyl]acetamide
CAS 852386-94-8C19H22ClN3O4S
![2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-(1-phenylethyl)acetamide chemical structure, C17H19ClN2O3S, CAS 499113-20-1](/s/AUPPKYXSZYESSX-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-(1-phenylethyl)acetamide
CAS 499113-20-1C17H19ClN2O3S
![2-[Benzenesulfonyl(methyl)amino]-N-(1-phenylethyl)acetamide chemical structure, C17H20N2O3S, CAS 593262-12-5](/s/FNOXKRUIOGGJRB-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(methyl)amino]-N-(1-phenylethyl)acetamide
CAS 593262-12-5C17H20N2O3S
![N-Benzyl-2-[(4-fluorophenyl)sulfonylamino]propanamide chemical structure, C16H17FN2O3S, CAS 1008954-87-7](/s/VPFNEGRVILXLPJ-UHFFFAOYSA-N.svg)
N-Benzyl-2-[(4-fluorophenyl)sulfonylamino]propanamide
CAS 1008954-87-7C16H17FN2O3S
- 2-[(4-Fluorophenyl)sulfonylamino]-N-[(4-methylphenyl)methyl]propanamide1009245-91-3C17H19FN2O3S
- Methyl 2-[(2-{[(4-bromophenyl)sulfonyl]amino}acetyl)amino]-2-phenylacetate1100757-01-4C17H17BrN2O5S
- 4-Methyl-2-[(4-methylphenyl)sulfonylamino]-N-(1-phenylethyl)pentanamide1214160-37-8C21H28N2O3S
- Methyl 2-[(2-{[(4-chlorophenyl)sulfonyl]amino}acetyl)amino]-2-phenylacetate1008068-62-9C17H17ClN2O5S
- Methyl 2-[(2-{[(4-fluorophenyl)sulfonyl]amino}acetyl)amino]-2-phenylacetate1008465-64-2C17H17FN2O5S
- 2-[Methyl-(4-methylphenyl)sulfonylamino]-N-(1-phenylethyl)acetamide428841-06-9C18H22N2O3S
- 2-[[(4-Bromophenyl)sulfonyl]amino]-N-[(4-methylphenyl)methyl]propanamide1024026-30-9C17H19BrN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1251 chemicals
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals
O=C(NCCc1ccccc1)OCc1ccccc142 chemicals
O=C(CCc1ccccc1)NCCc1ccccc138 chemicals
c1ccc(CCCNCCc2ccccc2)cc138 chemicals
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals
c1ccc(CCNCCOc2ccccc2)cc126 chemicals
O=C(CCCOc1ccccc1)Nc1ccccc121 chemicals
O=C(COc1ccccc1)NCCc1ccccc120 chemicals