Murcko scaffold
Ring system with 3 rings and 24 atoms
26 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 24
- Chemicals
- 26
- With full pages
- 4
Scaffold SMILES
O=C(COC(=O)c1c[nH]c2ncccc2c1=O)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(COC(=O)c1c[nH]c2ncccc2c1=O)Nc1ccccc1](/scaffold/NANJZSKFOXAXOC-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 26 of 26 chemicals
![[2-(4-Bromoanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate chemical structure, C20H18BrN3O4, CAS 433320-71-9](/s/SGIBOUVTSJPDAO-UHFFFAOYSA-N.svg)
[2-(4-Bromoanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
CAS 433320-71-9C20H18BrN3O4
2-Oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 354539-03-0C21H18F3N3O4
2-Oxo-2-(phenylamino)ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 438597-14-9C20H19N3O4
![[(2,4-Difluorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C20H17F2N3O4, CAS 502891-17-0](/s/DDAKIIWMQZVTSZ-UHFFFAOYSA-N.svg)
[(2,4-Difluorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 502891-17-0C20H17F2N3O4
![[(2,4-Dimethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O6, CAS 892308-48-4](/s/FWGNQDMOURKKKW-UHFFFAOYSA-N.svg)
[(2,4-Dimethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 892308-48-4C22H23N3O6
![[(4-Chlorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C20H18ClN3O4, CAS 807338-39-2](/s/IREBCSIRCXKTCX-UHFFFAOYSA-N.svg)
[(4-Chlorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 807338-39-2C20H18ClN3O4
![[2-(5-Chloro-2-methoxyanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate chemical structure, C21H20ClN3O5, CAS 566141-19-3](/s/BWMJDSQVTBKMSM-UHFFFAOYSA-N.svg)
[2-(5-Chloro-2-methoxyanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
CAS 566141-19-3C21H20ClN3O5
![[(3,4-Dimethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O6, CAS 805301-74-0](/s/PHRRMLSLQMBIJN-UHFFFAOYSA-N.svg)
[(3,4-Dimethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 805301-74-0C22H23N3O6
![[(2-Ethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O5, CAS 566144-74-9](/s/KAMWUFBHJYHBSJ-UHFFFAOYSA-N.svg)
[(2-Ethoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 566144-74-9C22H23N3O5
![[(4-Methoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H21N3O5, CAS 566139-11-5](/s/MUHPHLXUXKQTTQ-UHFFFAOYSA-N.svg)
[(4-Methoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 566139-11-5C21H21N3O5
![[(3,5-Dimethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O4, CAS 503141-71-7](/s/KRRQMJJGDKIBCK-UHFFFAOYSA-N.svg)
[(3,5-Dimethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 503141-71-7C22H23N3O4
![[2-(3-Acetylanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate chemical structure, C22H21N3O5, CAS 478862-72-5](/s/MKDQHHKAAFVVDR-UHFFFAOYSA-N.svg)
[2-(3-Acetylanilino)-2-oxoethyl] 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
CAS 478862-72-5C22H21N3O5
![[(2-Ethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O4, CAS 892308-55-3](/s/SXFUIPORGRGZJN-UHFFFAOYSA-N.svg)
[(2-Ethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 892308-55-3C22H23N3O4
2-((4-(Ethoxycarbonyl)phenyl)amino)-2-oxoethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 562793-73-1C23H23N3O6
![[(3-Chloro-4-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H20ClN3O4, CAS 485794-59-0](/s/GHJUHBGCOZZYJQ-UHFFFAOYSA-N.svg)
[(3-Chloro-4-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 485794-59-0C21H20ClN3O4
![[(5-Chloro-2-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H20ClN3O4, CAS 474389-07-6](/s/CSORVCMFNUTLPP-UHFFFAOYSA-N.svg)
[(5-Chloro-2-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 474389-07-6C21H20ClN3O4
![[(3-Chloro-2-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H20ClN3O4, CAS 479523-72-3](/s/YFUFTBZWWNXYKF-UHFFFAOYSA-N.svg)
[(3-Chloro-2-methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 479523-72-3C21H20ClN3O4
![[(3-Ethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O4, CAS 892308-41-7](/s/ZPEGAEDZTKFCFK-UHFFFAOYSA-N.svg)
[(3-Ethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 892308-41-7C22H23N3O4
![[(4-Fluorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C20H18FN3O4, CAS 571949-67-2](/s/NHETWUDNASELCC-UHFFFAOYSA-N.svg)
[(4-Fluorophenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 571949-67-2C20H18FN3O4
![[(2,5-Dimethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H23N3O4, CAS 556828-60-5](/s/ITONCZCTEWWJCM-UHFFFAOYSA-N.svg)
[(2,5-Dimethylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 556828-60-5C22H23N3O4
![{[3-(Methylsulfanyl)phenyl]carbamoyl}methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H21N3O4S, CAS 892308-28-0](/s/SJOUUWVZDWXALE-UHFFFAOYSA-N.svg)
{[3-(Methylsulfanyl)phenyl]carbamoyl}methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 892308-28-0C21H21N3O4S
![[(3-Methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H21N3O4, CAS 892308-34-8](/s/YYAQCAFVLSEWGB-UHFFFAOYSA-N.svg)
[(3-Methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 892308-34-8C21H21N3O4
![[(2-Methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H21N3O4, CAS 558433-49-1](/s/KMCXAWUGWMCLQC-UHFFFAOYSA-N.svg)
[(2-Methylphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 558433-49-1C21H21N3O4
![[(3-Methoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C21H21N3O5, CAS 569635-57-0](/s/XSTBVLGKTAMZOU-UHFFFAOYSA-N.svg)
[(3-Methoxyphenyl)carbamoyl]methyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 569635-57-0C21H21N3O5
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CSc1nc(=O)n2ccccc2n1)NCc1ccccc115 chemicals
O=C(COC(=O)c1ccc2ccccc2n1)Nc1ccccc110 chemicals
O=C(CNC(=O)c1ccccc1)Nc1ccc2ccccc2c19 chemicals
O=C(Cn1ccc2ccccc2c1=O)NCCc1ccccc17 chemicals
O=C(CSC1=NS(=O)(=O)c2ccccc2N1)NCc1ccccc16 chemicals
S=C(N=CNc1ncc2ccccc2n1)Nc1ccccc16 chemicals
O=C(COc1ccccc1)NCC1COc2ccccc2O15 chemicals
O=C(CCSc1ccc2c(n1)CCCC2=O)Nc1ccccc15 chemicals![Scaffold O=C(NCCCN1CCCCC1)c1ccc2c(=O)[nH]c(=O)[nH]c2c1](/scaffold/FKVYRJCCWMMLHA-UHFFFAOYSA-N/structure.svg)
O=C(NCCCN1CCCCC1)c1ccc2c(=O)[nH]c(=O)[nH]c2c15 chemicals
O=C(CCSc1ccc2ccccc2n1)Nc1ccccc15 chemicals
O=C(COC(=O)c1cccnc1)Nc1ccc2c(c1)OCCO25 chemicals
O=C(COc1ccccc1)OCn1nnc2ccccc2c1=O4 chemicals