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Murcko scaffold

Ring system with 3 rings and 23 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
8
With full pages
5
Scaffold SMILES

O=C(COC(=O)c1cccnc1)Nc1ccc2c(c1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)c1cccnc1)Nc1ccc2c(c1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

[(2-Cyanoethyl)(2,3-dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 6-chloropyridine-3-carboxylate chemical structure, C19H16ClN3O5, CAS 848897-96-1
[(2-Cyanoethyl)(2,3-dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 6-chloropyridine-3-carboxylate
CAS 848897-96-1C19H16ClN3O5
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 2-chloropyridine-3-carboxylate chemical structure, C17H15ClN2O5, CAS 750640-31-4
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 2-chloropyridine-3-carboxylate
CAS 750640-31-4C17H15ClN2O5
[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 2-chloropyridine-3-carboxylate chemical structure, C16H13ClN2O5, CAS 502700-85-8
[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 2-chloropyridine-3-carboxylate
CAS 502700-85-8C16H13ClN2O5
2-(2,3-Dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl 5-bromopyridine-3-carboxylate chemical structure, C16H13BrN2O5, CAS 805256-91-1
2-(2,3-Dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl 5-bromopyridine-3-carboxylate
CAS 805256-91-1C16H13BrN2O5
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 2-(methylsulfanyl)pyridine-3-carboxylate chemical structure, C18H18N2O5S, CAS 848276-96-0
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 2-(methylsulfanyl)pyridine-3-carboxylate
CAS 848276-96-0C18H18N2O5S
[2-(2,3-Dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl] 6-chloropyridine-3-carboxylate chemical structure, C16H13ClN2O5, CAS 475415-63-5
[2-(2,3-Dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl] 6-chloropyridine-3-carboxylate
CAS 475415-63-5C16H13ClN2O5
[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 2-aminopyridine-3-carboxylate chemical structure, C16H15N3O5, CAS 875344-46-0
[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]methyl 2-aminopyridine-3-carboxylate
CAS 875344-46-0C16H15N3O5
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 6-chloropyridine-3-carboxylate chemical structure, C17H15ClN2O5, CAS 1009164-42-4
1-[(2,3-Dihydro-1,4-benzodioxin-6-yl)carbamoyl]ethyl 6-chloropyridine-3-carboxylate
CAS 1009164-42-4C17H15ClN2O5