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Murcko scaffold

Ring system with 3 rings and 18 atoms

41 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
41
With full pages
20
Scaffold SMILES

O=C(c1ccccc1)N1CCOc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCOc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

Ethyl 2-[4-(4-fluorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C19H18FNO4, CAS 439112-17-1
Ethyl 2-[4-(4-fluorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 439112-17-1C19H18FNO4
(4-Chlorophenyl)(2,3-dihydro-3-methyl-4H-1,4-benzoxazin-4-yl)methanone chemical structure, C16H14ClNO2, CAS 338747-60-7
(4-Chlorophenyl)(2,3-dihydro-3-methyl-4H-1,4-benzoxazin-4-yl)methanone
CAS 338747-60-7C16H14ClNO2
Ethyl 2-{4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate chemical structure, C20H18F3NO4, CAS 439112-05-7
Ethyl 2-{4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate
CAS 439112-05-7C20H18F3NO4
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](2-methylphenyl)methanone chemical structure, C20H23NO2, CAS 478048-72-5
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](2-methylphenyl)methanone
CAS 478048-72-5C20H23NO2
2-[4-(2-Chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetic acid chemical structure, C17H14ClNO4, CAS 439096-40-9
2-[4-(2-Chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetic acid
CAS 439096-40-9C17H14ClNO4
Methyl 2-[4-(4-chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C18H16ClNO4, CAS 861209-26-9
Methyl 2-[4-(4-chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 861209-26-9C18H16ClNO4
(4-Fluorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone chemical structure, C16H14FNO2, CAS 338747-71-0
(4-Fluorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone
CAS 338747-71-0C16H14FNO2
Methyl 2-{4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate chemical structure, C19H16F3NO4, CAS 439096-42-1
Methyl 2-{4-[3-(trifluoromethyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate
CAS 439096-42-1C19H16F3NO4
2-[4-(4-Methoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetic acid chemical structure, C18H17NO5, CAS 439107-27-4
2-[4-(4-Methoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetic acid
CAS 439107-27-4C18H17NO5
Methyl 2-[4-(3-chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C18H16ClNO4, CAS 439096-36-3
Methyl 2-[4-(3-chlorobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 439096-36-3C18H16ClNO4
[3-(tert-Butyl)-6-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl][3-(trifluoromethyl)phenyl]methanone chemical structure, C21H22F3NO2, CAS 672951-42-7
[3-(tert-Butyl)-6-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl][3-(trifluoromethyl)phenyl]methanone
CAS 672951-42-7C21H22F3NO2
(2-Chlorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone chemical structure, C16H14ClNO2, CAS 478043-10-6
(2-Chlorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone
CAS 478043-10-6C16H14ClNO2
(3-Methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)(4-methylphenyl)methanone chemical structure, C17H17NO2, CAS 338747-54-9
(3-Methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)(4-methylphenyl)methanone
CAS 338747-54-9C17H17NO2
Methyl 2-[4-(4-bromobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C18H16BrNO4, CAS 439096-46-5
Methyl 2-[4-(4-bromobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 439096-46-5C18H16BrNO4
Methyl 2-[4-(4-methoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C19H19NO5, CAS 861212-87-5
Methyl 2-[4-(4-methoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 861212-87-5C19H19NO5
Ethyl 2-[4-(3-nitrobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C19H18N2O6, CAS 478259-96-0
Ethyl 2-[4-(3-nitrobenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 478259-96-0C19H18N2O6
[3-(tert-Butyl)-6-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl](3-methoxyphenyl)methanone chemical structure, C21H25NO3, CAS 672951-43-8
[3-(tert-Butyl)-6-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl](3-methoxyphenyl)methanone
CAS 672951-43-8C21H25NO3
(2,4-Dichlorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone chemical structure, C16H13Cl2NO2, CAS 478043-15-1
(2,4-Dichlorophenyl)(3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methanone
CAS 478043-15-1C16H13Cl2NO2
Ethyl 2-[4-(4-methylbenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C20H21NO4, CAS 439112-01-3
Ethyl 2-[4-(4-methylbenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 439112-01-3C20H21NO4
Methyl 2-{4-[4-(tert-butyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate chemical structure, C22H25NO4, CAS 861209-29-2
Methyl 2-{4-[4-(tert-butyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}acetate
CAS 861209-29-2C22H25NO4
2H-1,4-Benzoxazine, 4-benzoyl-3,4-dihydro-6-methyl- chemical structure, C16H15NO2, CAS 71472-54-3
2H-1,4-Benzoxazine, 4-benzoyl-3,4-dihydro-6-methyl-
CAS 71472-54-3C16H15NO2
Methyl 2-[4-(3,4,5-trimethoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate chemical structure, C21H23NO7, CAS 439096-44-3
Methyl 2-[4-(3,4,5-trimethoxybenzoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-yl]acetate
CAS 439096-44-3C21H23NO7
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](2-chlorophenyl)methanone chemical structure, C19H20ClNO2, CAS 478043-17-3
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](2-chlorophenyl)methanone
CAS 478043-17-3C19H20ClNO2
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](3-chlorophenyl)methanone chemical structure, C19H20ClNO2, CAS 478048-69-0
[3-(tert-Butyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl](3-chlorophenyl)methanone
CAS 478048-69-0C19H20ClNO2