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Murcko scaffold

N-Benzyltetrahydrothiophen-3-amine 1,1-dioxide scaffold

53 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
53
With full pages
6
Scaffold SMILES

O=S1(=O)CCC(NCc2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Benzyltetrahydrothiophen-3-amine 1,1-dioxide page
Murcko scaffold O=S1(=O)CCC(NCc2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

4-(((1,1-Dioxidotetrahydrothiophen-3-yl)amino)methyl)benzoic acid chemical structure, C12H15NO4S, CAS 170938-29-1
4-(((1,1-Dioxidotetrahydrothiophen-3-yl)amino)methyl)benzoic acid
CAS 170938-29-1C12H15NO4S
N-Benzyltetrahydrothiophen-3-amine 1,1-dioxide chemical structure, C11H15NO2S, CAS 321580-44-3
N-Benzyltetrahydrothiophen-3-amine 1,1-dioxide
CAS 321580-44-3C11H15NO2S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)isobutyramide chemical structure, C17H25NO3S, CAS 578757-06-9
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)isobutyramide
CAS 578757-06-9C17H25NO3S
1-[(3,4-Dimethoxyphenyl)methyl]-1-(1,1-dioxothiolan-3-yl)-3-prop-2-enylthiourea chemical structure, C17H24N2O4S2, CAS 833433-18-4
1-[(3,4-Dimethoxyphenyl)methyl]-1-(1,1-dioxothiolan-3-yl)-3-prop-2-enylthiourea
CAS 833433-18-4C17H24N2O4S2
1-(1,1-Dioxothiolan-3-yl)-1-[(2-fluorophenyl)methyl]-3-prop-2-enylthiourea chemical structure, C15H19FN2O2S2, CAS 833439-11-5
1-(1,1-Dioxothiolan-3-yl)-1-[(2-fluorophenyl)methyl]-3-prop-2-enylthiourea
CAS 833439-11-5C15H19FN2O2S2
N-(1,1-Dioxidotetrahydro-3-thienyl)-N-(4-fluorobenzyl)-3-methylbutanamide chemical structure, C16H22FNO3S, CAS 838879-78-0
N-(1,1-Dioxidotetrahydro-3-thienyl)-N-(4-fluorobenzyl)-3-methylbutanamide
CAS 838879-78-0C16H22FNO3S
3-(Benzylamino)-4-hydroxytetrahydrothiophene 1,1-dioxide chemical structure, C11H15NO3S, CAS 321580-40-9
3-(Benzylamino)-4-hydroxytetrahydrothiophene 1,1-dioxide
CAS 321580-40-9C11H15NO3S
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-methylpropanamide chemical structure, C17H26N2O3S, CAS 575466-28-3
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-methylpropanamide
CAS 575466-28-3C17H26N2O3S
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-2-methylpropanamide chemical structure, C15H20ClNO3S, CAS 578737-18-5
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-2-methylpropanamide
CAS 578737-18-5C15H20ClNO3S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-methyl-N-[4-(propan-2-yl)benzyl]propanamide chemical structure, C18H27NO3S, CAS 577769-29-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-methyl-N-[4-(propan-2-yl)benzyl]propanamide
CAS 577769-29-0C18H27NO3S
N-Benzyl-2-chloro-N-(1,1-dioxo-1lambda6-thiolan-3-yl)acetamide chemical structure, C13H16ClNO3S, CAS 453576-43-7
N-Benzyl-2-chloro-N-(1,1-dioxo-1lambda6-thiolan-3-yl)acetamide
CAS 453576-43-7C13H16ClNO3S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)pentanamide chemical structure, C16H22FNO3S, CAS 847164-20-9
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)pentanamide
CAS 847164-20-9C16H22FNO3S
3-((4-(Dimethylamino)benzyl)amino)tetrahydrothiophene 1,1-dioxide chemical structure, C13H20N2O2S, CAS 879861-39-9
3-((4-(Dimethylamino)benzyl)amino)tetrahydrothiophene 1,1-dioxide
CAS 879861-39-9C13H20N2O2S
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methylbutanamide chemical structure, C16H22ClNO3S, CAS 620557-85-9
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methylbutanamide
CAS 620557-85-9C16H22ClNO3S
3-((3,4-Dimethoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide chemical structure, C13H19NO4S, CAS 887833-56-9
3-((3,4-Dimethoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide
CAS 887833-56-9C13H19NO4S
3-{[(2-Fluorophenyl)methyl]amino}thiolane-1,1-dione chemical structure, C11H14FNO2S, CAS 853574-06-8
3-{[(2-Fluorophenyl)methyl]amino}thiolane-1,1-dione
CAS 853574-06-8C11H14FNO2S
3-((4-Methoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide chemical structure, C12H17NO3S, CAS 851452-57-8
3-((4-Methoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide
CAS 851452-57-8C12H17NO3S
(3S,4S)-4-(Benzylamino)-1,1-dioxothiolan-3-ol chemical structure, C11H15NO3S, CAS 1821735-81-2
(3S,4S)-4-(Benzylamino)-1,1-dioxothiolan-3-ol
CAS 1821735-81-2C11H15NO3S
3-((3-Methoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide chemical structure, C12H17NO3S, CAS 887833-55-8
3-((3-Methoxybenzyl)amino)tetrahydrothiophene 1,1-dioxide
CAS 887833-55-8C12H17NO3S
3-((4-Chlorobenzyl)amino)tetrahydrothiophene 1,1-dioxide chemical structure, C11H14ClNO2S, CAS 887833-57-0
3-((4-Chlorobenzyl)amino)tetrahydrothiophene 1,1-dioxide
CAS 887833-57-0C11H14ClNO2S
3-{[(3-Chlorophenyl)methyl]amino}thiolane-1,1-dione chemical structure, C11H14ClNO2S, CAS 879906-84-0
3-{[(3-Chlorophenyl)methyl]amino}thiolane-1,1-dione
CAS 879906-84-0C11H14ClNO2S
3-({[4-(Diethylamino)phenyl]methyl}amino)thiolane-1,1-dione chemical structure, C15H24N2O2S, CAS 881440-99-9
3-({[4-(Diethylamino)phenyl]methyl}amino)thiolane-1,1-dione
CAS 881440-99-9C15H24N2O2S
3-{[(4-Fluorophenyl)methyl]amino}thiolane-1,1-dione chemical structure, C11H14FNO2S, CAS 881441-13-0
3-{[(4-Fluorophenyl)methyl]amino}thiolane-1,1-dione
CAS 881441-13-0C11H14FNO2S
3-{[(4-Ethoxyphenyl)methyl]amino}thiolane-1,1-dione chemical structure, C13H19NO3S, CAS 873856-29-2
3-{[(4-Ethoxyphenyl)methyl]amino}thiolane-1,1-dione
CAS 873856-29-2C13H19NO3S