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Murcko scaffold

Ring system with 4 rings and 23 atoms

44 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
44
With full pages
5
Scaffold SMILES

O=C1CC(c2ccccc2)Cc2nc(N3CCNCC3)ncc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)Cc2nc(N3CCNCC3)ncc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

2-(4-Ethylpiperazin-1-yl)-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C23H30N4O4, CAS 726200-40-4
2-(4-Ethylpiperazin-1-yl)-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 726200-40-4C23H30N4O4
7-(3,4-Dimethoxyphenyl)-2-(4-ethylpiperazinyl)-6,7,8-trihydroquinazolin-5-one chemical structure, C22H28N4O3, CAS 777866-65-6
7-(3,4-Dimethoxyphenyl)-2-(4-ethylpiperazinyl)-6,7,8-trihydroquinazolin-5-one
CAS 777866-65-6C22H28N4O3
2-(4-Ethylpiperazin-1-yl)-7-[4-(propan-2-yl)phenyl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C23H30N4O, CAS 777866-64-5
2-(4-Ethylpiperazin-1-yl)-7-[4-(propan-2-yl)phenyl]-7,8-dihydroquinazolin-5(6H)-one
CAS 777866-64-5C23H30N4O
Ethyl 4-[7-(4-methoxyphenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate chemical structure, C23H28N4O4, CAS 777866-90-7
Ethyl 4-[7-(4-methoxyphenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate
CAS 777866-90-7C23H28N4O4
7-(2-Fluorophenyl)-2-(4-methylpiperazinyl)-6,7,8-trihydroquinazolin-5-one chemical structure, C19H21FN4O, CAS 777866-82-7
7-(2-Fluorophenyl)-2-(4-methylpiperazinyl)-6,7,8-trihydroquinazolin-5-one
CAS 777866-82-7C19H21FN4O
7-(2,4-Dimethoxyphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C21H26N4O3, CAS 879063-55-5
7-(2,4-Dimethoxyphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879063-55-5C21H26N4O3
Ethyl 4-[7-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate chemical structure, C21H23FN4O3, CAS 879625-27-1
Ethyl 4-[7-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate
CAS 879625-27-1C21H23FN4O3
Ethyl 4-[7-(3,4-dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate chemical structure, C23H28N4O5, CAS 879063-85-1
Ethyl 4-[7-(3,4-dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate
CAS 879063-85-1C23H28N4O5
4-[7-(2,4-Dimethoxyphenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carbaldehyde chemical structure, C22H26N4O4, CAS 885891-77-0
4-[7-(2,4-Dimethoxyphenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carbaldehyde
CAS 885891-77-0C22H26N4O4
7-(4-Methylphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C20H24N4O, CAS 777866-83-8
7-(4-Methylphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 777866-83-8C20H24N4O
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one chemical structure, C21H26N4O3, CAS 886141-15-7
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(2-hydroxyphenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one
CAS 886141-15-7C21H26N4O3
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methyl-7-(4-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C22H28N4O2, CAS 886140-42-7
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methyl-7-(4-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 886140-42-7C22H28N4O2
7-(4-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C20H23ClN4O2, CAS 878993-83-0
7-(4-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 878993-83-0C20H23ClN4O2
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(4-methoxyphenyl)-7,8-dihydro-6H-quinazolin-5-one chemical structure, C21H26N4O3, CAS 886140-59-6
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(4-methoxyphenyl)-7,8-dihydro-6H-quinazolin-5-one
CAS 886140-59-6C21H26N4O3
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-phenyl-7,8-dihydro-6H-quinazolin-5-one chemical structure, C20H24N4O2, CAS 879043-09-1
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-phenyl-7,8-dihydro-6H-quinazolin-5-one
CAS 879043-09-1C20H24N4O2
7-(3-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one chemical structure, C21H25ClN4O2, CAS 886141-09-9
7-(3-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one
CAS 886141-09-9C21H25ClN4O2
7-(4-Fluorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one chemical structure, C20H23FN4O2, CAS 886140-54-1
7-(4-Fluorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-7,8-dihydroquinazolin-5(6H)-one
CAS 886140-54-1C20H23FN4O2
7-(2-Hydroxyphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C19H22N4O2, CAS 879063-49-7
7-(2-Hydroxyphenyl)-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879063-49-7C19H22N4O2
7-(2,4-Dimethoxyphenyl)-4-methyl-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C22H28N4O3, CAS 879063-67-9
7-(2,4-Dimethoxyphenyl)-4-methyl-2-(4-methylpiperazin-1-yl)-7,8-dihydroquinazolin-5(6H)-one
CAS 879063-67-9C22H28N4O3
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C23H30N4O5, CAS 886140-89-2
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(3,4,5-trimethoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 886140-89-2C23H30N4O5
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methyl-7-(2-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one chemical structure, C22H28N4O2, CAS 929839-53-2
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methyl-7-(2-methylphenyl)-7,8-dihydroquinazolin-5(6H)-one
CAS 929839-53-2C22H28N4O2
4-[4-Methyl-7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carbaldehyde chemical structure, C21H24N4O2, CAS 878977-55-0
4-[4-Methyl-7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carbaldehyde
CAS 878977-55-0C21H24N4O2
Ethyl 4-[7-(4-chlorophenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate chemical structure, C22H25ClN4O3, CAS 878977-59-4
Ethyl 4-[7-(4-chlorophenyl)-4-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]piperazine-1-carboxylate
CAS 878977-59-4C22H25ClN4O3
7-(4-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one chemical structure, C21H25ClN4O2, CAS 921112-90-5
7-(4-Chlorophenyl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4-methyl-7,8-dihydroquinazolin-5(6H)-one
CAS 921112-90-5C21H25ClN4O2