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Murcko scaffold

1-(Thiazol-2-yl)pyrrolidin-2-one scaffold

16 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
16
With full pages
3
Scaffold SMILES

O=C1CCCN1c1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thiazol-2-yl)pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1c1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-Pyrrolidinone, 1-(5-nitro-2-thiazolyl)- chemical structure, C7H7N3O3S, CAS 13109-99-4
2-Pyrrolidinone, 1-(5-nitro-2-thiazolyl)-
CAS 13109-99-4C7H7N3O3S
1-(Thiazol-2-yl)pyrrolidin-2-one chemical structure, C7H8N2OS, CAS 37762-96-2
1-(Thiazol-2-yl)pyrrolidin-2-one
CAS 37762-96-2C7H8N2OS
Ethyl 4-methyl-2-(2-oxopyrrolidin-1-yl)-1,3-thiazole-5-carboxylate chemical structure, C11H14N2O3S, CAS 959307-64-3
Ethyl 4-methyl-2-(2-oxopyrrolidin-1-yl)-1,3-thiazole-5-carboxylate
CAS 959307-64-3C11H14N2O3S
1-(4-Methylthiazol-2-yl)pyrrolidin-2-one chemical structure, C8H10N2OS, CAS 37762-97-3
1-(4-Methylthiazol-2-yl)pyrrolidin-2-one
CAS 37762-97-3C8H10N2OS
5-Oxo-1-(1,3-thiazol-2-yl)pyrrolidine-3-carboxylic acid chemical structure, C8H8N2O3S, CAS 914637-54-0
5-Oxo-1-(1,3-thiazol-2-yl)pyrrolidine-3-carboxylic acid
CAS 914637-54-0C8H8N2O3S
2-(2-Oxo-1-pyrrolidinyl)-4-thiazoleacetic acid chemical structure, C9H10N2O3S, CAS 848658-78-6
2-(2-Oxo-1-pyrrolidinyl)-4-thiazoleacetic acid
CAS 848658-78-6C9H10N2O3S
3-Bromo-1-(1,3-thiazol-2-yl)pyrrolidin-2-one chemical structure, C7H7BrN2OS, CAS 178946-31-1
3-Bromo-1-(1,3-thiazol-2-yl)pyrrolidin-2-one
CAS 178946-31-1C7H7BrN2OS
4-Bromo-2-(pyrrolidinon-1-yl)thiazole chemical structure, C7H7BrN2OS, CAS 1086381-67-0
4-Bromo-2-(pyrrolidinon-1-yl)thiazole
CAS 1086381-67-0C7H7BrN2OS
1-(5-Methyl-2-thiazolyl)-2-pyrrolidinone chemical structure, C8H10N2OS, CAS 1864819-89-5
1-(5-Methyl-2-thiazolyl)-2-pyrrolidinone
CAS 1864819-89-5C8H10N2OS
3-Pyrrolidinecarboxylic acid, 1-(4-ethyl-5-methyl-2-thiazolyl)-5-oxo- chemical structure, C11H14N2O3S, CAS 1293039-33-4
3-Pyrrolidinecarboxylic acid, 1-(4-ethyl-5-methyl-2-thiazolyl)-5-oxo-
CAS 1293039-33-4C11H14N2O3S
2-Pyrrolidinone, 1-(4,5-dimethyl-2-thiazolyl)-4-hydroxy- chemical structure, C9H12N2O2S, CAS 1342135-57-2
2-Pyrrolidinone, 1-(4,5-dimethyl-2-thiazolyl)-4-hydroxy-
CAS 1342135-57-2C9H12N2O2S
4,5-Dibromo-2-(pyrrolidinon-1-yl)thiazole chemical structure, C7H6Br2N2OS, CAS 1314353-99-5
4,5-Dibromo-2-(pyrrolidinon-1-yl)thiazole
CAS 1314353-99-5C7H6Br2N2OS
Ethyl 2-(2-Oxo-1-pyrrolidinyl)thiazole-4-carboxylate chemical structure, C10H12N2O3S, CAS 955400-28-9
Ethyl 2-(2-Oxo-1-pyrrolidinyl)thiazole-4-carboxylate
CAS 955400-28-9C10H12N2O3S
2-(2-Oxo-1-pyrrolidinyl)thiazole-4-carboxylic Acid chemical structure, C8H8N2O3S, CAS 955401-05-5
2-(2-Oxo-1-pyrrolidinyl)thiazole-4-carboxylic Acid
CAS 955401-05-5C8H8N2O3S
4-Ethyl-2-(2-oxopyrrolidin-1-yl)thiazole-5-carboxylic acid chemical structure, C10H12N2O3S, CAS 1708288-34-9
4-Ethyl-2-(2-oxopyrrolidin-1-yl)thiazole-5-carboxylic acid
CAS 1708288-34-9C10H12N2O3S
5-Oxo-1-(thiazol-2-yl)pyrrolidine-2-carboxylic acid chemical structure, C8H8N2O3S, CAS 2089672-71-7
5-Oxo-1-(thiazol-2-yl)pyrrolidine-2-carboxylic acid
CAS 2089672-71-7C8H8N2O3S