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Murcko scaffold

Ring system with 4 rings and 26 atoms

128 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
128
With full pages
2
Scaffold SMILES

O=C(CSc1ncnc2c1nnn2-c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ncnc2c1nnn2-c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 128 chemicals

2-[3-(4-Methoxyphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H15F3N6O2S, CAS 863500-50-9
2-[3-(4-Methoxyphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 863500-50-9C20H15F3N6O2S
N-Phenyl-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C19H16N6OS, CAS 863459-15-8
N-Phenyl-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-15-8C19H16N6OS
N-(4-Methylphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H18N6OS, CAS 863459-18-1
N-(4-Methylphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-18-1C20H18N6OS
N-(2,3-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C21H20N6OS, CAS 863459-19-2
N-(2,3-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-19-2C21H20N6OS
N-(2,5-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C21H20N6OS, CAS 863459-20-5
N-(2,5-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-20-5C21H20N6OS
N-(2,4-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C21H20N6OS, CAS 863459-21-6
N-(2,4-Dimethylphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-21-6C21H20N6OS
N-(4-Ethylphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C21H20N6OS, CAS 863459-24-9
N-(4-Ethylphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-24-9C21H20N6OS
N-(2-Fluorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C19H15FN6OS, CAS 863459-28-3
N-(2-Fluorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-28-3C19H15FN6OS
N-(4-Fluorophenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C19H15FN6OS, CAS 863459-31-8
N-(4-Fluorophenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-31-8C19H15FN6OS
N-(3-Chlorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C19H15ClN6OS, CAS 863459-32-9
N-(3-Chlorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-32-9C19H15ClN6OS
N-(2,4-Difluorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C19H14F2N6OS, CAS 863459-35-2
N-(2,4-Difluorophenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-35-2C19H14F2N6OS
N-(2-Methoxyphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H18N6O2S, CAS 863459-38-5
N-(2-Methoxyphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-38-5C20H18N6O2S
N-(3-Methoxyphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H18N6O2S, CAS 863459-39-6
N-(3-Methoxyphenyl)-2-[3-(4-methylphenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-39-6C20H18N6O2S
N-(4-Methoxyphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C20H18N6O2S, CAS 863459-40-9
N-(4-Methoxyphenyl)-2-((3-(p-tolyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-40-9C20H18N6O2S
2-((3-(4-Fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)-N-phenylacetamide chemical structure, C18H13FN6OS, CAS 863459-85-2
2-((3-(4-Fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)-N-phenylacetamide
CAS 863459-85-2C18H13FN6OS
2-[3-(4-Fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanyl-N-(3-methylphenyl)acetamide chemical structure, C19H15FN6OS, CAS 863459-87-4
2-[3-(4-Fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanyl-N-(3-methylphenyl)acetamide
CAS 863459-87-4C19H15FN6OS
2-((3-(4-Fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)-N-(p-tolyl)acetamide chemical structure, C19H15FN6OS, CAS 863459-88-5
2-((3-(4-Fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)-N-(p-tolyl)acetamide
CAS 863459-88-5C19H15FN6OS
N-(2,3-Dimethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H17FN6OS, CAS 863459-89-6
N-(2,3-Dimethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-89-6C20H17FN6OS
N-(2,5-Dimethylphenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C20H17FN6OS, CAS 863459-90-9
N-(2,5-Dimethylphenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-90-9C20H17FN6OS
N-(2,4-Dimethylphenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C20H17FN6OS, CAS 863459-91-0
N-(2,4-Dimethylphenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-91-0C20H17FN6OS
N-(3,5-Dimethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H17FN6OS, CAS 863459-92-1
N-(3,5-Dimethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-92-1C20H17FN6OS
N-(4-Ethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C20H17FN6OS, CAS 863459-94-3
N-(4-Ethylphenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-94-3C20H17FN6OS
N-(2-Fluorophenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide chemical structure, C18H12F2N6OS, CAS 863459-96-5
N-(2-Fluorophenyl)-2-[3-(4-fluorophenyl)triazolo[4,5-d]pyrimidin-7-yl]sulfanylacetamide
CAS 863459-96-5C18H12F2N6OS
N-(3-Fluorophenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide chemical structure, C18H12F2N6OS, CAS 863459-97-6
N-(3-Fluorophenyl)-2-((3-(4-fluorophenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
CAS 863459-97-6C18H12F2N6OS