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Murcko scaffold

Ring system with 4 rings and 20 atoms

125 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 20
Chemicals: 125
With full pages: 13

Scaffold SMILES

O=c1c(=Cc2ccccc2)sc2nc3ccccc3n12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(=Cc2ccccc2)sc2nc3ccccc3n12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 125 chemicals

2-[(2-Fluorophenyl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C16H9FN2OS, CAS 300377-11-1

2-[(2-Fluorophenyl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 300377-11-1C₁₆H₉FN₂OS

(2Z)-2-(2,4-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C18H14N2O3S, CAS 1622998-05-3

(2Z)-2-(2,4-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 1622998-05-3C₁₈H₁₄N₂O₃S

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-hydroxy-3-methoxyphenyl)methylene)- chemical structure, C17H12N2O3S, CAS 88498-93-5

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-hydroxy-3-methoxyphenyl)methylene)-

CAS 88498-93-5C₁₇H₁₂N₂O₃S

2-[(4-Hydroxy-3-methoxyphenyl)methylene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C17H12N2O3S, CAS 1443655-11-5

2-[(4-Hydroxy-3-methoxyphenyl)methylene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 1443655-11-5C₁₇H₁₂N₂O₃S

2-(2,5-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C18H14N2O3S, CAS 301229-48-1

2-(2,5-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 301229-48-1C₁₈H₁₄N₂O₃S

(Z)-2-(3-Ethoxy-4-hydroxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one chemical structure, C18H14N2O3S, CAS 329701-48-6

(Z)-2-(3-Ethoxy-4-hydroxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one

CAS 329701-48-6C₁₈H₁₄N₂O₃S

(2Z)-2-[(4-Propan-2-ylphenyl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one chemical structure, C19H16N2OS, CAS 301157-37-9

(2Z)-2-[(4-Propan-2-ylphenyl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one

CAS 301157-37-9C₁₉H₁₆N₂OS

2-(2-Fluorobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C16H9FN2OS, CAS 1443655-09-1

2-(2-Fluorobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 1443655-09-1C₁₆H₉FN₂OS

(2Z)-2-(2,3-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C18H14N2O3S, CAS 301229-62-9

(2Z)-2-(2,3-Dimethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 301229-62-9C₁₈H₁₄N₂O₃S

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-(phenylmethylene)- chemical structure, C16H10N2OS, CAS 41887-58-5

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-(phenylmethylene)-

CAS 41887-58-5C₁₆H₁₀N₂OS

(4Z)-4-(Phenylmethylidene)-5-thia-2,7-diazatricyclo[6.4.0.0,2,6]dodeca-1(12),6,8,10-tetraen-3-one chemical structure, C16H10N2OS, CAS 155099-26-6

(4Z)-4-(Phenylmethylidene)-5-thia-2,7-diazatricyclo[6.4.0.0,2,6]dodeca-1(12),6,8,10-tetraen-3-one

CAS 155099-26-6C₁₆H₁₀N₂OS

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-(dimethylamino)phenyl)methylene)- chemical structure, C18H15N3OS, CAS 23983-04-2

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-(dimethylamino)phenyl)methylene)-

CAS 23983-04-2C₁₈H₁₅N₃OS

2-(3,4-Dimethoxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one chemical structure, C18H14N2O3S, CAS 290835-37-9

2-(3,4-Dimethoxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one

CAS 290835-37-9C₁₈H₁₄N₂O₃S

4-[(Z)-(3-Oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]phenyl acetate chemical structure, C18H12N2O3S, CAS 41776-86-7

4-[(Z)-(3-Oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]phenyl acetate

CAS 41776-86-7C₁₈H₁₂N₂O₃S

(2Z)-2-(4-tert-Butylbenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C20H18N2OS, CAS 311795-44-5

(2Z)-2-(4-tert-Butylbenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 311795-44-5C₂₀H₁₈N₂OS

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((2-hydroxyphenyl)methylene)- chemical structure, C16H10N2O2S, CAS 41776-82-3

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((2-hydroxyphenyl)methylene)-

CAS 41776-82-3C₁₆H₁₀N₂O₂S

2-(2-Methoxybenzylidene)(1,3)thiazolo(3,2-A)benzimidazol-3(2H)-one chemical structure, C17H12N2O2S, CAS 41776-88-9

2-(2-Methoxybenzylidene)(1,3)thiazolo(3,2-A)benzimidazol-3(2H)-one

CAS 41776-88-9C₁₇H₁₂N₂O₂S

Thiazolo[3.2-a]benzimidazol-3(2H)-one, 2-(2-methoxybenzylideno)- chemical structure, C17H12N2O2S, CAS 1443655-10-4

Thiazolo[3.2-a]benzimidazol-3(2H)-one, 2-(2-methoxybenzylideno)-

CAS 1443655-10-4C₁₇H₁₂N₂O₂S

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-methoxyphenyl)methylene)- chemical structure, C17H12N2O2S, CAS 41776-89-0

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((4-methoxyphenyl)methylene)-

CAS 41776-89-0C₁₇H₁₂N₂O₂S

(2Z)-2-(4-Methoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C17H12N2O2S, CAS 155099-28-8

(2Z)-2-(4-Methoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 155099-28-8C₁₇H₁₂N₂O₂S

(2Z)-2-[4-(Methylsulfanyl)benzylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C17H12N2OS2, CAS 311783-63-8

(2Z)-2-[4-(Methylsulfanyl)benzylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 311783-63-8C₁₇H₁₂N₂OS₂

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((2-chlorophenyl)methylene)- chemical structure, C16H9ClN2OS, CAS 23983-05-3

Thiazolo(3,2-a)benzimidazol-3(2H)-one, 2-((2-chlorophenyl)methylene)-

CAS 23983-05-3C₁₆H₉ClN₂OS

Methyl 4-[(3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]benzoate chemical structure, C18H12N2O3S, CAS 310456-42-9

Methyl 4-[(3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]benzoate

CAS 310456-42-9C₁₈H₁₂N₂O₃S

(2Z)-2-(2-Ethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one chemical structure, C18H14N2O2S, CAS 30065-04-4

(2Z)-2-(2-Ethoxybenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS 30065-04-4C₁₈H₁₄N₂O₂S