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Murcko scaffold

Ring system with 2 rings and 11 atoms

62 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
62
With full pages
7
Scaffold SMILES

c1cnc(-c2nccs2)cn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cnc(-c2nccs2)cn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

5-Methyl-2-(2-pyrazinyl)-1,3-thiazol-4-ol chemical structure, C8H7N3OS, CAS 338409-28-2
5-Methyl-2-(2-pyrazinyl)-1,3-thiazol-4-ol
CAS 338409-28-2C8H7N3OS
2-(4-Methoxy-5-methyl-1,3-thiazol-2-yl)pyrazine chemical structure, C9H9N3OS, CAS 338409-47-5
2-(4-Methoxy-5-methyl-1,3-thiazol-2-yl)pyrazine
CAS 338409-47-5C9H9N3OS
Ethyl 4-methyl-2-(2-pyrazinyl)thiazole-5-carboxylate chemical structure, C11H11N3O2S, CAS 256529-18-7
Ethyl 4-methyl-2-(2-pyrazinyl)thiazole-5-carboxylate
CAS 256529-18-7C11H11N3O2S
Ethyl 2-(pyrazin-2-yl)thiazole-4-carboxylate chemical structure, C10H9N3O2S, CAS 256529-19-8
Ethyl 2-(pyrazin-2-yl)thiazole-4-carboxylate
CAS 256529-19-8C10H9N3O2S
2-(2-(Pyrazin-2-yl)-1,3-thiazol-4-yl)acetic acid chemical structure, C9H7N3O2S, CAS 256529-20-1
2-(2-(Pyrazin-2-yl)-1,3-thiazol-4-yl)acetic acid
CAS 256529-20-1C9H7N3O2S
5-Acetyl-4-methyl-2-(2-pyrazinyl)thiazole chemical structure, C10H9N3OS, CAS 260789-23-9
5-Acetyl-4-methyl-2-(2-pyrazinyl)thiazole
CAS 260789-23-9C10H9N3OS
4-Methyl-2-(2-pyrazinyl)thiazole-5-carboxylic acid chemical structure, C9H7N3O2S, CAS 216959-92-1
4-Methyl-2-(2-pyrazinyl)thiazole-5-carboxylic acid
CAS 216959-92-1C9H7N3O2S
4-Methyl-2-(2-pyrazinyl)-1,3-thiazole-5-carbonyl chloride chemical structure, C9H6ClN3OS, CAS 257876-11-2
4-Methyl-2-(2-pyrazinyl)-1,3-thiazole-5-carbonyl chloride
CAS 257876-11-2C9H6ClN3OS
2-Bromo-1-(4-methyl-2-(2-pyrazinyl)-5-thiazolyl)ethanone chemical structure, C10H8BrN3OS, CAS 423768-43-8
2-Bromo-1-(4-methyl-2-(2-pyrazinyl)-5-thiazolyl)ethanone
CAS 423768-43-8C10H8BrN3OS
[4-Methyl-2-(2-pyrazinyl)-1,3-thiazol-5-yl]methanol chemical structure, C9H9N3OS, CAS 352018-94-1
[4-Methyl-2-(2-pyrazinyl)-1,3-thiazol-5-yl]methanol
CAS 352018-94-1C9H9N3OS
Ethyl 2-(2-pyrazin-2-yl-1,3-thiazol-4-yl)acetate chemical structure, C11H11N3O2S, CAS 80653-70-9
Ethyl 2-(2-pyrazin-2-yl-1,3-thiazol-4-yl)acetate
CAS 80653-70-9C11H11N3O2S
2-(Pyrazin-2-yl)-1,3-thiazole-4-carboxylic acid chemical structure, C8H5N3O2S, CAS 115311-44-9
2-(Pyrazin-2-yl)-1,3-thiazole-4-carboxylic acid
CAS 115311-44-9C8H5N3O2S
2-(Pyrazin-2-yl)thiazole-4-carboxamide chemical structure, C8H6N4OS, CAS 1235296-44-2
2-(Pyrazin-2-yl)thiazole-4-carboxamide
CAS 1235296-44-2C8H6N4OS
2-(5-Isocyanato-4-methyl-1,3-thiazol-2-yl)pyrazine chemical structure, C9H6N4OS, CAS 799283-95-7
2-(5-Isocyanato-4-methyl-1,3-thiazol-2-yl)pyrazine
CAS 799283-95-7C9H6N4OS
(2-Pyrazin-2-yl-1,3-thiazol-4-yl)methanol chemical structure, C8H7N3OS, CAS 805250-60-6
(2-Pyrazin-2-yl-1,3-thiazol-4-yl)methanol
CAS 805250-60-6C8H7N3OS
(2-Pyrazin-2-yl-1,3-thiazol-4-yl)methylamine chemical structure, C8H8N4S, CAS 1033693-08-1
(2-Pyrazin-2-yl-1,3-thiazol-4-yl)methylamine
CAS 1033693-08-1C8H8N4S
2-(2-Pyrazin-2-yl-1,3-thiazol-4-yl)ethanamine chemical structure, C9H10N4S, CAS 1060817-06-2
2-(2-Pyrazin-2-yl-1,3-thiazol-4-yl)ethanamine
CAS 1060817-06-2C9H10N4S
2-(Pyrazin-2-yl)-1,3-thiazole-5-carboxylic acid chemical structure, C8H5N3O2S, CAS 1014630-94-4
2-(Pyrazin-2-yl)-1,3-thiazole-5-carboxylic acid
CAS 1014630-94-4C8H5N3O2S
4-Bromo-2-(6'-chloro-2'-pyrazinyl)thiazole chemical structure, C7H3BrClN3S, CAS 1185311-37-8
4-Bromo-2-(6'-chloro-2'-pyrazinyl)thiazole
CAS 1185311-37-8C7H3BrClN3S
5-Bromo-2-(6'-chloro-2'-pyrazinyl)thiazole chemical structure, C7H3BrClN3S, CAS 1185319-86-1
5-Bromo-2-(6'-chloro-2'-pyrazinyl)thiazole
CAS 1185319-86-1C7H3BrClN3S
4-Bromo-2-(5'-amino-2'-pyrazinyl)thiazole chemical structure, C7H5BrN4S, CAS 1185312-33-7
4-Bromo-2-(5'-amino-2'-pyrazinyl)thiazole
CAS 1185312-33-7C7H5BrN4S
5-Bromo-2-(5'-amino-2'-pyrazinyl)thiazole chemical structure, C7H5BrN4S, CAS 1185313-20-5
5-Bromo-2-(5'-amino-2'-pyrazinyl)thiazole
CAS 1185313-20-5C7H5BrN4S
Ethyl 2-(2-(pyrazin-2-yl)thiazole-4-carboxamido)acetate chemical structure, C12H12N4O3S, CAS 1235387-20-8
Ethyl 2-(2-(pyrazin-2-yl)thiazole-4-carboxamido)acetate
CAS 1235387-20-8C12H12N4O3S
N,N-Diethyl-2-(pyrazin-2-yl)thiazole-4-carboxamide chemical structure, C12H14N4OS, CAS 1235666-08-6
N,N-Diethyl-2-(pyrazin-2-yl)thiazole-4-carboxamide
CAS 1235666-08-6C12H14N4OS