Murcko scaffold
Ring system with 3 rings and 18 atoms
55 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 18
- Chemicals
- 55
- With full pages
- 16
Scaffold SMILES
c1ccc(OCCn2ccc3ccccc32)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 55 chemicals
![1-[2-(2-Chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C17H14ClNO2, CAS 340318-80-1](/s/LEXJQXDFUWITRB-UHFFFAOYSA-N.svg)
1-[2-(2-Chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 340318-80-1C17H14ClNO2
![1-[2-(4-Chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C17H14ClNO2, CAS 329061-82-7](/s/DLIKEJOWZOFFKG-UHFFFAOYSA-N.svg)
1-[2-(4-Chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 329061-82-7C17H14ClNO2
![1-[2-(2-Fluorophenoxy)ethyl]indole-3-carbonitrile chemical structure, C17H13FN2O, CAS 371922-89-3](/s/IVOXOYGHPHAHHR-UHFFFAOYSA-N.svg)
1-[2-(2-Fluorophenoxy)ethyl]indole-3-carbonitrile
CAS 371922-89-3C17H13FN2O
![1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C19H19NO2, CAS 340318-67-4](/s/RGHRLCVKJYMWHV-UHFFFAOYSA-N.svg)
1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 340318-67-4C19H19NO2
![1-[2-(2-Methoxyphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C18H17NO3, CAS 299936-03-1](/s/PUNPSTCJCHVHQR-UHFFFAOYSA-N.svg)
1-[2-(2-Methoxyphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 299936-03-1C18H17NO3
![1-[2-(2-Fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C17H14FNO2, CAS 309732-86-3](/s/BGRFHHVVAOWQAA-UHFFFAOYSA-N.svg)
1-[2-(2-Fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 309732-86-3C17H14FNO2
Ethyl 5-hydroxy-2-methyl-1-(2-phenoxyethyl)indole-3-carboxylate
CAS 296772-86-6C20H21NO4
1-(2-Phenoxyethyl)-1H-indole-3-carbaldehyde
CAS 299936-51-9C17H15NO2
![1-{2-[4-(Propan-2-yloxy)phenoxy]ethyl}-1H-indole-3-carbaldehyde chemical structure, C20H21NO3, CAS 445407-37-4](/s/VJHWAJVXIUNOQU-UHFFFAOYSA-N.svg)
1-{2-[4-(Propan-2-yloxy)phenoxy]ethyl}-1H-indole-3-carbaldehyde
CAS 445407-37-4C20H21NO3
![1-[2-(2-Chlorophenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde chemical structure, C18H16ClNO2, CAS 433241-35-1](/s/FJUXXMUUSLVJNB-UHFFFAOYSA-N.svg)
1-[2-(2-Chlorophenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde
CAS 433241-35-1C18H16ClNO2
![(E)-3-[1-[2-(4-Methylphenoxy)ethyl]indol-3-yl]prop-2-enoic acid chemical structure, C20H19NO3, CAS 1523528-01-9](/s/HNRQHXNEKIVLTR-DHZHZOJOSA-N.svg)
(E)-3-[1-[2-(4-Methylphenoxy)ethyl]indol-3-yl]prop-2-enoic acid
CAS 1523528-01-9C20H19NO3
![1-[2-(2-Isopropyl-5-methylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde chemical structure, C22H25NO2, CAS 433250-51-2](/s/NAMKOBPGIAWDKA-UHFFFAOYSA-N.svg)
1-[2-(2-Isopropyl-5-methylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde
CAS 433250-51-2C22H25NO2
![2-Methyl-1-[2-(2-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C19H19NO2, CAS 640254-35-9](/s/YDVZJZFBXPOEPC-UHFFFAOYSA-N.svg)
2-Methyl-1-[2-(2-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 640254-35-9C19H19NO2
![1-[2-(5-Methyl-2-propan-2-ylphenoxy)ethyl]indole-3-carbonitrile chemical structure, C21H22N2O, CAS 347322-94-5](/s/UFLVHUCLBULCFA-UHFFFAOYSA-N.svg)
1-[2-(5-Methyl-2-propan-2-ylphenoxy)ethyl]indole-3-carbonitrile
CAS 347322-94-5C21H22N2O
![1-[2-(2-Fluorophenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde chemical structure, C18H16FNO2, CAS 432003-58-2](/s/ROCRNIAZIISJEO-UHFFFAOYSA-N.svg)
1-[2-(2-Fluorophenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde
CAS 432003-58-2C18H16FNO2
![1-[2-(4-Chloro-3-methylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde chemical structure, C19H18ClNO2, CAS 432009-93-3](/s/LNSCQIUJCWWXSR-UHFFFAOYSA-N.svg)
1-[2-(4-Chloro-3-methylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde
CAS 432009-93-3C19H18ClNO2
![1-[2-(2-Methylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C18H17NO2, CAS 299935-67-4](/s/VLODCKSYZHDUEN-UHFFFAOYSA-N.svg)
1-[2-(2-Methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 299935-67-4C18H17NO2
![1-[2-(4-Methylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C18H17NO2, CAS 333412-99-0](/s/MOQFAKITSOFEFT-UHFFFAOYSA-N.svg)
1-[2-(4-Methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 333412-99-0C18H17NO2
2-Methyl-1-(2-phenoxyethyl)-1H-indole-3-carbaldehyde
CAS 340318-64-1C18H17NO2
![1-[2-(4-tert-Butylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C21H23NO2, CAS 6367-58-4](/s/FPPJMIHRGUHUCJ-UHFFFAOYSA-N.svg)
1-[2-(4-tert-Butylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 6367-58-4C21H23NO2
![1-[2-(4-Chloro-3-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C18H16ClNO2, CAS 340318-74-3](/s/XTPUDOQCDZVZSN-UHFFFAOYSA-N.svg)
1-[2-(4-Chloro-3-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 340318-74-3C18H16ClNO2
![1-[2-(4-Fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C17H14FNO2, CAS 340318-78-7](/s/LZDGENIAAFJSHO-UHFFFAOYSA-N.svg)
1-[2-(4-Fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 340318-78-7C17H14FNO2
![2-Methyl-1-[2-(4-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde chemical structure, C19H19NO2, CAS 432017-93-1](/s/PCHAACFAFNHVNH-UHFFFAOYSA-N.svg)
2-Methyl-1-[2-(4-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
CAS 432017-93-1C19H19NO2
![1-[2-(3,4-Dimethylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde chemical structure, C20H21NO2, CAS 496950-89-1](/s/NEHAXMXMFNXVHX-UHFFFAOYSA-N.svg)
1-[2-(3,4-Dimethylphenoxy)ethyl]-2-methyl-1H-indole-3-carbaldehyde
CAS 496950-89-1C20H21NO2
- 1-[2-(2-Allylphenoxy)ethyl]-1H-indole-3-carbaldehyde299443-33-7C20H19NO2
- 1-[2-(2,6-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde428490-16-8C19H19NO2
- 1-[2-(2-Chlorophenoxy)ethyl]indole-3-carbonitrile347323-00-6C17H13ClN2O
- 1-[2-(4-Fluorophenoxy)ethyl]indole-3-carbonitrile347323-06-2C17H13FN2O
- 1-[2-(4-Methoxyphenoxy)ethyl]-2-methylindole-3-carbaldehyde639503-88-1C19H19NO3
- 1-[2-(3,4-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde347320-21-2C19H19NO2
- 5-Bromo-1-[2-(2-chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde433320-27-5C17H13BrClNO2
- 1-[1-[2-(4-Methylphenoxy)ethyl]-1H-indol-3-yl]ethanone799264-85-0C19H19NO2
- Ethyl 5-hydroxy-2-methyl-1-[2-(4-methylphenoxy)ethyl]-1H-indole-3-carboxylate311323-11-2C21H23NO4
- (3Z)-3-(Hydroxyimino)-1-[2-(2-methylphenoxy)ethyl]-1,3-dihydro-2H-indol-2-one867136-28-5C17H16N2O3
- 1-[1-[2-(4-tert-Butylphenoxy)ethyl]indol-3-yl]-2,2,2-trifluoroethanone530110-98-6C22H22F3NO2
- 1-[7-Ethyl-1-[2-(2-methoxyphenoxy)ethyl]indol-3-yl]-2,2,2-trifluoroethanone693268-65-4C21H20F3NO3
- 2,2,2-Trifluoro-1-[1-[2-(4-methoxyphenoxy)ethyl]-1H-indol-3-yl]ethanone626205-52-5C19H16F3NO3
- 1-[2-(3,5-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde884497-57-8C19H19NO2
- 1-[2-(2,4-Dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde496966-32-6C19H19NO2
- 1-[2-(2,5-Dimethylphenoxy)ethyl]indole-3-carboxylic acid878978-76-8C19H19NO3
- Ethyl 1-[2-(4-formylphenoxy)ethyl]-1H-indole-2-carboxylate205371-44-4C20H19NO4
- Ethyl (2E)-2-cyano-3-{1-[2-(4-methoxyphenoxy)ethyl]-1H-indol-3-yl}acrylate1164552-13-9C23H22N2O4
- 1-[2-(2-Chlorophenoxy)ethyl]-1H-indole-3-carboxylic acid892255-06-0C17H14ClNO3
- 5-Bromo-1-[2-(2-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde530124-62-0C18H16BrNO2
- Ethyl 5-chloro-1-(2-(4-chlorophenoxy)ethyl)-1H-indole-7-carboxylate1196048-27-7C19H17Cl2NO3
- 5-Chloro-1-(2-(4-chlorophenoxy)ethyl)-1H-indole-7-carboxylic acid1196048-34-6C17H13Cl2NO3
- Methyl 1-(2-(4-chlorophenoxy)ethyl)-1H-indole-7-carboxylate1196047-62-7C18H16ClNO3
- 1-(2-Phenoxy-ethyl)-1H-indole-4-carboxylic acid1160755-33-8C17H15NO3
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(OCCn2cnc3ccccc32)cc145 chemicals![Scaffold O=c1[nH]c(=O)c2c(ncn2CCCc2ccccc2)[nH]1](/scaffold/ZRAIUQWSDYKKRJ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CCCc2ccccc2)[nH]141 chemicals
O=C(Cn1cnc2ccccc21)Nc1ccccc123 chemicals![Scaffold O=C(N=Nc1c[nH]c2ccccc12)c1ccccc1](/scaffold/RGLMVNANQLTKCX-UHFFFAOYSA-N/structure.svg)
O=C(N=Nc1c[nH]c2ccccc12)c1ccccc121 chemicals
O=C(Cn1c(=O)oc2ccccc21)Nc1ccccc119 chemicals![Scaffold O=C(Cn1cnc2[nH]c(=O)[nH]c(=O)c21)Nc1ccccc1](/scaffold/ZWJKCVAAPQWJQO-UHFFFAOYSA-N/structure.svg)
O=C(Cn1cnc2[nH]c(=O)[nH]c(=O)c21)Nc1ccccc118 chemicals
O=C(Cn1ccc2ccccc21)Nc1ccccc116 chemicals![Scaffold O=c1[nH]c(=O)c2c(ncn2CCOc2ccccc2)[nH]1](/scaffold/NHEHGYKCFDHWBC-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CCOc2ccccc2)[nH]115 chemicals
O=C(COc1ccccc1)N1CCc2ccccc2112 chemicals
O=C(CSc1ccccc1)c1cnc2ccccn1210 chemicals
O=C(Cc1coc2ccccc12)Nc1ccccc18 chemicals
O=C1C(=O)N(CCOc2ccccc2)c2ccccc218 chemicals