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Murcko scaffold

Ring system with 4 rings and 28 atoms

23 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 23
With full pages: 4

Scaffold SMILES

O=C1C(=O)N(CCN2CCNCC2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=O)N(CCN2CCNCC2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

4-[Hydroxy-(4-methoxyphenyl)methylidene]-5-(4-methoxyphenyl)-1-(2-piperazin-1-ylethyl)pyrrolidine-2,3-dione chemical structure, C25H29N3O5

4-[Hydroxy-(4-methoxyphenyl)methylidene]-5-(4-methoxyphenyl)-1-(2-piperazin-1-ylethyl)pyrrolidine-2,3-dione

C₂₅H₂₉N₃O₅

3-Hydroxy-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H33N3O4

3-Hydroxy-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₇H₃₃N₃O₄

5-(4-tert-Butylphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H35N3O4

5-(4-tert-Butylphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₈H₃₅N₃O₄

4-Benzoyl-3-hydroxy-5-(4-methoxyphenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H27N3O4, CAS 462069-92-7

4-Benzoyl-3-hydroxy-5-(4-methoxyphenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 462069-92-7C₂₄H₂₇N₃O₄

3-Hydroxy-5-(4-methylphenyl)-4-(phenylcarbonyl)-1-[2-(piperazin-1-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H27N3O3, CAS 728016-81-7

3-Hydroxy-5-(4-methylphenyl)-4-(phenylcarbonyl)-1-[2-(piperazin-1-yl)ethyl]-1,5-dihydro-2H-pyrrol-2-one

CAS 728016-81-7C₂₄H₂₇N₃O₃

5-(3,4-Dichlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H25Cl2N3O4, CAS 431927-94-5

5-(3,4-Dichlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 431927-94-5C₂₄H₂₅Cl₂N₃O₄

5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H26ClN3O4, CAS 371126-78-2

5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 371126-78-2C₂₄H₂₆ClN₃O₄

5-(4-Bromophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(1-piperazinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H26BrN3O4, CAS 432003-16-2

5-(4-Bromophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(1-piperazinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one

CAS 432003-16-2C₂₄H₂₆BrN₃O₄

5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(1-piperazinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H31N3O6, CAS 432005-46-4

5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(1-piperazinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one

CAS 432005-46-4C₂₆H₃₁N₃O₆

3-Hydroxy-4-(4-methoxybenzoyl)-5-(3-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H26N4O6, CAS 432008-17-8

3-Hydroxy-4-(4-methoxybenzoyl)-5-(3-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 432008-17-8C₂₄H₂₆N₄O₆

5-(2-Fluorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H26FN3O4, CAS 371207-37-3

5-(2-Fluorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 371207-37-3C₂₄H₂₆FN₃O₄

3-Hydroxy-4-(4-methoxybenzoyl)-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O4, CAS 439947-85-0

3-Hydroxy-4-(4-methoxybenzoyl)-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 439947-85-0C₂₅H₂₉N₃O₄

3-Hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-5-[4-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H31N3O5, CAS 431980-62-0

3-Hydroxy-4-(4-methoxybenzoyl)-1-[2-(piperazin-1-yl)ethyl]-5-[4-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 431980-62-0C₂₇H₃₁N₃O₅

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(4-isopropylphenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C29H37N3O4, CAS 384795-81-7

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(4-isopropylphenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 384795-81-7C₂₉H₃₇N₃O₄

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(4-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H30N4O6, CAS 371118-65-9

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(4-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 371118-65-9C₂₆H₃₀N₄O₆

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(3-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H30N4O6, CAS 433316-59-7

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(3-nitrophenyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 433316-59-7C₂₆H₃₀N₄O₆

5-(4-Chlorophenyl)-3-hydroxy-1-[2-(piperazin-1-yl)ethyl]-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H30ClN3O4, CAS 433324-64-2

5-(4-Chlorophenyl)-3-hydroxy-1-[2-(piperazin-1-yl)ethyl]-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 433324-64-2C₂₆H₃₀ClN₃O₄

3-Hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H29N3O5, CAS 439947-86-1

3-Hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 439947-86-1C₂₅H₂₉N₃O₅

3-Hydroxy-4-{[4-(methylethoxy)phenyl]carbonyl}-5-(4-methylphenyl)-1-(2-piperaz inylethyl)-3-pyrrolin-2-one chemical structure, C27H33N3O4, CAS 384800-71-9

3-Hydroxy-4-{[4-(methylethoxy)phenyl]carbonyl}-5-(4-methylphenyl)-1-(2-piperaz inylethyl)-3-pyrrolin-2-one

CAS 384800-71-9C₂₇H₃₃N₃O₄

5-(4-Fluorophenyl)-3-hydroxy-4-(4-isopropoxybenzoyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H30FN3O4, CAS 371211-29-9

5-(4-Fluorophenyl)-3-hydroxy-4-(4-isopropoxybenzoyl)-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 371211-29-9C₂₆H₃₀FN₃O₄

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-phenyl-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H31N3O4, CAS 371233-69-1

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-phenyl-1-(2-(piperazin-1-yl)ethyl)-1H-pyrrol-2(5H)-one

CAS 371233-69-1C₂₆H₃₁N₃O₄

(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(4-methoxyphenyl)methylidene]-1-[2-(piperazin-1-yl)ethyl]pyrrolidine-2,3-dione chemical structure, C28H35N3O4, CAS 371127-92-3

(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(4-methoxyphenyl)methylidene]-1-[2-(piperazin-1-yl)ethyl]pyrrolidine-2,3-dione

CAS 371127-92-3C₂₈H₃₅N₃O₄

4-Benzoyl-3-hydroxy-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H27N3O3

4-Benzoyl-3-hydroxy-5-(4-methylphenyl)-1-[2-(piperazin-1-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₇N₃O₃