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Murcko scaffold

6-((5-(Benzylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione scaffold

122 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
122
With full pages
3
Scaffold SMILES

O=c1cc(Cc2nnc(SCc3ccccc3)n2-c2ccccc2)[nH]c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-((5-(Benzylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione page
Murcko scaffold O=c1cc(Cc2nnc(SCc3ccccc3)n2-c2ccccc2)[nH]c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 122 chemicals

6-[[5-[(2,4-Dichlorophenyl)methylsulfanyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H17Cl2N5O3S, CAS 892471-96-4
6-[[5-[(2,4-Dichlorophenyl)methylsulfanyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 892471-96-4C21H17Cl2N5O3S
6-((4-(4-Fluorophenyl)-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H15F4N5O2S, CAS 892472-51-4
6-((4-(4-Fluorophenyl)-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 892472-51-4C21H15F4N5O2S
6-((4-(4-Fluorophenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C20H15FN6O4S, CAS 852154-43-9
6-((4-(4-Fluorophenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852154-43-9C20H15FN6O4S
6-((5-((4-Chlorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18ClN5O2S, CAS 852047-88-2
6-((5-((4-Chlorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852047-88-2C21H18ClN5O2S
6-((4-(3-Methoxyphenyl)-5-((3-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18N6O5S, CAS 852152-67-1
6-((4-(3-Methoxyphenyl)-5-((3-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852152-67-1C21H18N6O5S
6-[[5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-(4-chlorophenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C20H14Cl2FN5O2S, CAS 892473-05-1
6-[[5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-(4-chlorophenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 892473-05-1C20H14Cl2FN5O2S
6-((5-((2-Fluorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18FN5O2S, CAS 852047-95-1
6-((5-((2-Fluorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852047-95-1C21H18FN5O2S
6-((5-((2-Chloro-6-fluorobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H19ClFN5O3S, CAS 852153-71-0
6-((5-((2-Chloro-6-fluorobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852153-71-0C22H19ClFN5O3S
6-((4-(3-Methoxyphenyl)-5-((3-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H21N5O3S, CAS 852049-23-1
6-((4-(3-Methoxyphenyl)-5-((3-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852049-23-1C22H21N5O3S
6-[[5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C20H15ClFN5O2S, CAS 852047-16-6
6-[[5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-phenyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852047-16-6C20H15ClFN5O2S
6-((4-(3-Methoxyphenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18N6O5S, CAS 852049-21-9
6-((4-(3-Methoxyphenyl)-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852049-21-9C21H18N6O5S
6-[[5-[(2-Fluorophenyl)methylsulfanyl]-4-(3-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H18FN5O3S, CAS 852152-64-8
6-[[5-[(2-Fluorophenyl)methylsulfanyl]-4-(3-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852152-64-8C21H18FN5O3S
6-((5-((2-Chlorobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H20ClN5O3S, CAS 852153-73-2
6-((5-((2-Chlorobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852153-73-2C22H20ClN5O3S
6-((4-(3-Methoxyphenyl)-5-((4-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H21N5O3S, CAS 852152-63-7
6-((4-(3-Methoxyphenyl)-5-((4-methylbenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852152-63-7C22H21N5O3S
6-((4-(4-Ethoxyphenyl)-5-((3-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H20FN5O3S, CAS 852153-66-3
6-((4-(4-Ethoxyphenyl)-5-((3-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852153-66-3C22H20FN5O3S
6-[[5-[(4-Bromophenyl)methylsulfanyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H18BrN5O3S, CAS 852153-17-4
6-[[5-[(4-Bromophenyl)methylsulfanyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852153-17-4C21H18BrN5O3S
6-((4-(2,5-Dimethylphenyl)-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C23H20F3N5O2S, CAS 896677-21-7
6-((4-(2,5-Dimethylphenyl)-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 896677-21-7C23H20F3N5O2S
6-[[4-(2,5-Dimethylphenyl)-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C22H20FN5O2S, CAS 852048-62-5
6-[[4-(2,5-Dimethylphenyl)-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852048-62-5C22H20FN5O2S
6-((5-((3-Chlorobenzyl)thio)-4-(2,5-dimethylphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H20ClN5O2S, CAS 852048-64-7
6-((5-((3-Chlorobenzyl)thio)-4-(2,5-dimethylphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852048-64-7C22H20ClN5O2S
6-((4-(2,5-Dimethylphenyl)-5-((3-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C22H20N6O4S, CAS 852048-65-8
6-((4-(2,5-Dimethylphenyl)-5-((3-nitrobenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852048-65-8C22H20N6O4S
6-[[4-(4-Fluorophenyl)-5-[(2-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H18FN5O2S, CAS 852154-41-7
6-[[4-(4-Fluorophenyl)-5-[(2-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852154-41-7C21H18FN5O2S
6-((5-((4-Fluorobenzyl)thio)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18FN5O3S, CAS 852153-16-3
6-((5-((4-Fluorobenzyl)thio)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852153-16-3C21H18FN5O3S
6-((5-((4-Fluorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18FN5O2S, CAS 852047-85-9
6-((5-((4-Fluorobenzyl)thio)-4-(m-tolyl)-4H-1,2,4-triazol-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
CAS 852047-85-9C21H18FN5O2S
6-[[5-[(4-Bromophenyl)methylsulfanyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione chemical structure, C21H18BrN5O2S, CAS 852047-86-0
6-[[5-[(4-Bromophenyl)methylsulfanyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
CAS 852047-86-0C21H18BrN5O2S