Murcko scaffold
2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-N-phenylacetamide scaffold
63 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 63
- With full pages
- 11
Scaffold SMILES
O=C(CSc1nnc2c(n1)[nH]c1ccccc12)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(CSc1nnc2c(n1)[nH]c1ccccc12)Nc1ccccc1](/scaffold/PAKGEFSXOKPBSS-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 63 chemicals
![2-[(5-Methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide chemical structure, C20H20N6O3S2, CAS 312273-86-2](/s/URODFBXVUZEVIP-UHFFFAOYSA-N.svg)
2-[(5-Methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide
CAS 312273-86-2C20H20N6O3S2
![2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide chemical structure, C22H24N6O3S2, CAS 312276-31-6](/s/AUGDQZHCUQAPAB-UHFFFAOYSA-N.svg)
2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide
CAS 312276-31-6C22H24N6O3S2
![2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide chemical structure, C21H22N6O3S2, CAS 296790-16-4](/s/PNFMPGNWILEJPJ-UHFFFAOYSA-N.svg)
2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)butanamide
CAS 296790-16-4C21H22N6O3S2
![2-{[5-(Prop-2-en-1-yl)-5H-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanyl}-N-(4-sulfamoylphenyl)butanamide chemical structure, C22H22N6O3S2, CAS 312273-82-8](/s/BNGWHACUDYEECS-UHFFFAOYSA-N.svg)
2-{[5-(Prop-2-en-1-yl)-5H-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanyl}-N-(4-sulfamoylphenyl)butanamide
CAS 312273-82-8C22H22N6O3S2
![N-(2-Cyanophenyl)-2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C20H16N6OS, CAS 312496-22-3](/s/ZZRAECUAWNOJJY-UHFFFAOYSA-N.svg)
N-(2-Cyanophenyl)-2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 312496-22-3C20H16N6OS
![N-(2-Cyanophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C23H22N6OS, CAS 332382-94-2](/s/YATXLMDKCMBPEV-UHFFFAOYSA-N.svg)
N-(2-Cyanophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 332382-94-2C23H22N6OS
![N-(2-Methoxyphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C21H21N5O2S, CAS 332382-92-0](/s/NYWAZLOWPXQRKM-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 332382-92-0C21H21N5O2S
![N-(4-Nitrophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C22H22N6O3S, CAS 425657-83-6](/s/FSVZBCYBEQDCAF-UHFFFAOYSA-N.svg)
N-(4-Nitrophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 425657-83-6C22H22N6O3S
![2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C21H18F3N5OS, CAS 312266-86-7](/s/LMRVUEMCGHVMTH-UHFFFAOYSA-N.svg)
2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 312266-86-7C21H18F3N5OS
![2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)acetamide chemical structure, C20H20N6O3S2, CAS 296898-08-3](/s/LMGSMAGEQSSXER-UHFFFAOYSA-N.svg)
2-[(5-Propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)acetamide
CAS 296898-08-3C20H20N6O3S2
![N-(4-Nitrophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C20H18N6O3S, CAS 335209-17-1](/s/GVCBULPDPRPDLJ-UHFFFAOYSA-N.svg)
N-(4-Nitrophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 335209-17-1C20H18N6O3S
![N-(3-Acetylphenyl)-2-[(5-propyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C24H25N5O2S, CAS 335209-21-7](/s/ZWFHETPBANFCLG-UHFFFAOYSA-N.svg)
N-(3-Acetylphenyl)-2-[(5-propyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 335209-21-7C24H25N5O2S
![N-(4-Chlorophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C20H18ClN5OS, CAS 335209-18-2](/s/DGQKNGMEZGAPQY-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 335209-18-2C20H18ClN5OS
![2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-nitrophenyl)butanamide chemical structure, C21H20N6O3S, CAS 404914-89-2](/s/KGFWQCRYNMUOSC-UHFFFAOYSA-N.svg)
2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-nitrophenyl)butanamide
CAS 404914-89-2C21H20N6O3S
![N-(4-Acetylphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C22H21N5O2S, CAS 296896-70-3](/s/ZLLKSYMUFSVPLE-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 296896-70-3C22H21N5O2S
![N-(4-Nitrophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C22H20N6O3S, CAS 426244-88-4](/s/CEZPPVPLFSOVQB-UHFFFAOYSA-N.svg)
N-(4-Nitrophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 426244-88-4C22H20N6O3S
![N-(4-Methoxyphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C21H21N5O2S, CAS 432499-75-7](/s/BUXXWNILQIUYSY-UHFFFAOYSA-N.svg)
N-(4-Methoxyphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 432499-75-7C21H21N5O2S
![N-(2-Methoxyphenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C21H19N5O2S, CAS 550300-43-1](/s/XPXZIUBCLHZLPV-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 550300-43-1C21H19N5O2S
![N-(4-Acetamidophenyl)-2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C20H18N6O2S, CAS 486400-81-1](/s/DWPHSBZWOSZOOP-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 486400-81-1C20H18N6O2S
![N-(2-Methoxyphenyl)-2-[(5-propan-2-yl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C23H25N5O2S, CAS 522651-24-7](/s/UELUGZLMCRICCD-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-[(5-propan-2-yl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 522651-24-7C23H25N5O2S
![N-(4-Acetamidophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C22H20N6O2S, CAS 550301-62-7](/s/OXIBQPHHOYOOTE-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 550301-62-7C22H20N6O2S
![N-(4-Acetamidophenyl)-2-[(5-butyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C23H24N6O2S, CAS 694457-83-5](/s/MDSZUHOJNMNHJP-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[(5-butyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 694457-83-5C23H24N6O2S
![N-(4-Acetamidophenyl)-2-[(8-bromo-5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide chemical structure, C20H17BrN6O2S, CAS 694463-63-3](/s/QWMNBFSPVMFCPO-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[(8-bromo-5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
CAS 694463-63-3C20H17BrN6O2S
![N-(4-Acetamidophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide chemical structure, C24H24N6O2S, CAS 694466-54-1](/s/FGWKVPVVMQEYOK-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide
CAS 694466-54-1C24H24N6O2S
- 2-[(5-Butyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)acetamide713096-61-8C21H22N6O3S2
- N-(4-Acetamidophenyl)-2-[(5-butyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanamide713098-60-3C25H28N6O2S
- N-(4-Acetylphenyl)-2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]propanamide830350-96-4C23H23N5O2S
- 2-[(5-Methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide330555-36-7C19H14F3N5OS
- N-(4-Chlorophenyl)-2-[(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide312531-94-5C18H14ClN5OS
- 2-[(5-Methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-nitrophenyl)acetamide351226-97-6C18H14N6O3S
- 2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)acetamide296898-02-7C19H18N6O3S2
- N-(4-Chlorophenyl)-2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide351226-98-7C19H16ClN5OS
- 2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-nitrophenyl)acetamide337489-52-8C19H16N6O3S
- 2-[(5-Prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-sulfamoylphenyl)acetamide296772-69-5C20H18N6O3S2
- N-(4-Chlorophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide337489-59-5C20H16ClN5OS
- N-(4-Nitrophenyl)-2-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide330555-44-7C20H16N6O3S
- 2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide522650-83-5C22H23N5O2S
- N-(4-Acetyl-phenyl)-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsulfanyl)-acetamide296799-49-0C19H15N5O2S
- 2-(5H-[1,2,4]Triazino[5,6-b]indol-3-ylsulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide296772-66-2C18H12F3N5OS
- 2-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide311782-23-7C20H16F3N5OS
- N-(2-Cyanophenyl)-2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide312498-79-6C19H14N6OS
- N-(4-Sulfamoylphenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)butanamide296898-13-0C19H18N6O3S2
- 2-[(8-Bromo-5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide309275-95-4C18H13BrClN5OS
- N-(2,4-Difluorophenyl)-2-[(5-propan-2-yl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide405279-40-5C20H17F2N5OS
- N-(2-Cyanophenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide332172-95-9C18H12N6OS
- N-(4-Nitrophenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)butanamide404914-73-4C19H16N6O3S
- N-(4-Methoxy-phenyl)-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsulfanyl)-acetamide310418-20-3C18H15N5O2S
- 2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-N-(o-tolyl)acetamide337354-78-6C18H15N5OS
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1ccccc1](/scaffold/ACIWZEIKODFZAM-UHFFFAOYSA-N/structure.svg)
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O=C(COc1ccccc1)Nc1ccc2c(c1)nc1n2CCSC12 chemicals![Scaffold O=C(CCc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1ccccc1](/scaffold/PLGVPZOKDRFSSI-UHFFFAOYSA-N/structure.svg)
O=C(CCc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1ccccc12 chemicals![Scaffold O=c1[nH]c(SCC=Cc2ccccc2)nc2sc3c(c12)CCCC3](/scaffold/TWZORCDXXUCSSZ-UHFFFAOYSA-N/structure.svg)
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O=C(CSc1ccccn1)Nc1ccc2c(c1)oc1ccccc122 chemicals![Scaffold O=C(CSc1nnc2c(n1)[nH]c1ccccc12)Nc1ncccn1](/scaffold/BUOHAAPTIWTPKF-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc2c(n1)[nH]c1ccccc12)Nc1ncccn11 chemical
O=C(CSc1ccccc1)Nc1ccc2c(c1)oc1ccccc121 chemical![Scaffold O=C(CSc1nnc2c(n1)[nH]c1ccccc12)NC1CCCCC1](/scaffold/RXEWMTBTMPJDNU-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc2c(n1)[nH]c1ccccc12)NC1CCCCC11 chemical
O=C(NC(=S)Nc1ccc2c(c1)Cc1ccccc1-2)c1ccccc11 chemical![Scaffold O=C(CSc1nc2sc3c(c2c(=O)[nH]1)CCCC3)NC1CCCCC1](/scaffold/XLAPQLXXMMZMHZ-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2sc3c(c2c(=O)[nH]1)CCCC3)NC1CCCCC11 chemical