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Murcko scaffold

5-(Benzylamino)pyrimidine-2,4(1H,3H)-dione scaffold

15 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
15
With full pages
6
Scaffold SMILES

O=c1[nH]cc(NCc2ccccc2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-(Benzylamino)pyrimidine-2,4(1H,3H)-dione page
Murcko scaffold O=c1[nH]cc(NCc2ccccc2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

6-Amino-5-(benzylamino)-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C11H12N4O2, CAS 25507-29-3
6-Amino-5-(benzylamino)-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 25507-29-3C11H12N4O2
5-(Benzylamino)pyrimidine-2,4(1H,3H)-dione chemical structure, C11H11N3O2, CAS 28485-19-0
5-(Benzylamino)pyrimidine-2,4(1H,3H)-dione
CAS 28485-19-0C11H11N3O2
6-Amino-5-benzylamino-1-butyl-1H-pyrimidine-2,4-dione chemical structure, C15H20N4O2, CAS 721415-06-1
6-Amino-5-benzylamino-1-butyl-1H-pyrimidine-2,4-dione
CAS 721415-06-1C15H20N4O2
6-Amino-1-butyl-5-{[(2-methoxyphenyl)methyl]amino}-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C16H22N4O3, CAS 571149-78-5
6-Amino-1-butyl-5-{[(2-methoxyphenyl)methyl]amino}-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 571149-78-5C16H22N4O3
6-Amino-5-benzylamino-1-(2-methoxy-ethyl)-1H-pyrimidine-2,4-dione chemical structure, C14H18N4O3, CAS 722467-81-4
6-Amino-5-benzylamino-1-(2-methoxy-ethyl)-1H-pyrimidine-2,4-dione
CAS 722467-81-4C14H18N4O3
2,4(1H,3H)-Pyrimidinedione, 5-[methyl(phenylmethyl)amino]- chemical structure, C12H13N3O2, CAS 141692-27-5
2,4(1H,3H)-Pyrimidinedione, 5-[methyl(phenylmethyl)amino]-
CAS 141692-27-5C12H13N3O2
N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzylbutyramide chemical structure, C16H20N4O3, CAS 191982-10-2
N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzylbutyramide
CAS 191982-10-2C16H20N4O3
6-Amino-5-benzylamino-1-methyluracil chemical structure, C12H14N4O2, CAS 70404-28-3
6-Amino-5-benzylamino-1-methyluracil
CAS 70404-28-3C12H14N4O2
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzyl-2-chloroacetamide chemical structure, C17H21ClN4O3, CAS 923762-54-3
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzyl-2-chloroacetamide
CAS 923762-54-3C17H21ClN4O3
N-(6-Amino-3-methyl-2,4-dioxo-1H-pyrimidin-5-yl)-N-benzyl-2,2,2-trifluoroacetamide chemical structure, C14H13F3N4O3, CAS 140379-38-0
N-(6-Amino-3-methyl-2,4-dioxo-1H-pyrimidin-5-yl)-N-benzyl-2,2,2-trifluoroacetamide
CAS 140379-38-0C14H13F3N4O3
5-(4-Chlorobenzylamino)-6-amino-1-methylpyrimidine-2,4(1H,3H)-dione chemical structure, C12H13ClN4O2, CAS 1178959-87-9
5-(4-Chlorobenzylamino)-6-amino-1-methylpyrimidine-2,4(1H,3H)-dione
CAS 1178959-87-9C12H13ClN4O2
6-Amino-1-ethyl-5-[(phenylmethyl)amino]-2,4(1H,3H)-pyrimidinedione chemical structure, C13H16N4O2, CAS 1183227-40-8
6-Amino-1-ethyl-5-[(phenylmethyl)amino]-2,4(1H,3H)-pyrimidinedione
CAS 1183227-40-8C13H16N4O2
6-Amino-5-[[(2-fluorophenyl)methyl]amino]-1-propyl-2,4(1H,3H)-pyrimidinedione chemical structure, C14H17FN4O2, CAS 1183099-59-3
6-Amino-5-[[(2-fluorophenyl)methyl]amino]-1-propyl-2,4(1H,3H)-pyrimidinedione
CAS 1183099-59-3C14H17FN4O2
6-Amino-5-(4-chlorobenzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione chemical structure, C12H13ClN4O2, CAS 1628284-90-1
6-Amino-5-(4-chlorobenzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione
CAS 1628284-90-1C12H13ClN4O2
5-[[(2-Fluorophenyl)methyl]amino]-2,4(1H,3H)-pyrimidinedione chemical structure, C11H10FN3O2, CAS 867151-45-9
5-[[(2-Fluorophenyl)methyl]amino]-2,4(1H,3H)-pyrimidinedione
CAS 867151-45-9C11H10FN3O2