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Hormones and steroids

Prednisolone

Also known as Metacortandralone, Deltacortril, Delta-Cortef

CAS 50-24-8Formula C21H28O5Molar mass 360.45 g/molEC 200-021-7
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 140 suppliers listed Drug substance
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Prednisolone chemical structure, C21H28O5, CAS 50-24-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
235 °C
Solubility
SPECIFIC OPTICAL ROTATION: +102.5 DEG @ 25 °C/D, PH OF 1% SOLN 7.5 TO 8.5, SOL IN WATER,…
HS code
293721
Category
Hormones and steroids
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Prednisolone?

Plain description, key identifiers and synonyms

Prednisolone is a glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. It has a role as an anti-inflammatory drug, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an adrenergic agent, a drug metabolite and an environmental contaminant. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a C21-steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a Delta(1)-progesterone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS number
50-24-8 CAS number cross-checkedOther or deprecated CAS: 8056-11-9
EC number
200-021-7
Molecular formula
C21H28O5
UNII
9PHQ9Y1OLM
MDL number
MFCD00003649
InChIKey
OIGNJSKKLXVSLS-VWUMJDOOSA-N
InChI
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Canonical SMILES
CC12C=CC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO
Isomeric SMILES
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O

Synonyms

  • Metacortandralone
  • Deltacortril
  • Delta-Cortef
  • Hydroretrocortine
  • Sterane
  • Codelcortone
  • Cortalone
  • Hydeltra
  • Prenolone
  • Deltahydrocortisone
  • Meti-Derm
  • Deltacortenol
  • Donisolone
  • Fernisolone
  • Hydrodeltalone
  • Paracortol
  • Precortisyl
  • Prelone
  • Hydroretrocortin
  • Decortin H
  • Hydrodeltisone
  • Precortancyl
  • Predniliderm
  • Delta F
  • Deltisilone
Show all 39 synonyms
  • Dicortol
  • Estilsona
  • Hydeltrone
  • PRDL
  • Precortilon
  • Prednelan
  • Prednicen
  • Scherisolon
  • Sterolone
  • Steran
  • Ulacort
  • Delta-stab
  • Fernisolone-P
  • Hostacortin H

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
Odorlessexp.
Melting point
235 °Cexp.
Solubility
SPECIFIC OPTICAL ROTATION: +102.5 DEG @ 25 °C/D, PH OF 1% SOLN 7.5 TO 8.5, SOL IN WATER, METHANOL, ETHANOL. /PHOSPHATE SODIUM/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
360.45 g/molcalc.
Exact mass
360.1937 Dacalc.
LogP (octanol/water)
1.56calc.
Topological polar surface area
94.83 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
26calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H332Harmful if inhaled.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Prednisolone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 140 suppliers
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Where suppliers are based

140 suppliers in 23 countries

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Prednisolone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Medicine, also available in acetate.

Commonly used to treat lymphoreticular neoplasms in combination with other drugs ... especially useful in treatment of leukemias and lymphomas of the central nervous system.

Therapeutic category: Glucocorticoid.

Therapeutic category (veterinary): Glucocorticoid.

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Hormonal
  • Glucocorticoids

Roles

  • adrenergic agent
  • anti-anaemic agent
  • anti-asthmatic agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • anti-ulcer drug
  • antifibrotic agent
  • antiglaucoma drug
  • antihypertensive agent
  • antiinfective agent
  • antineoplastic agent
  • antipsoriatic
  • antirheumatic drug
  • antispasmodic drug
  • antithyroid drug
  • antitubercular agent
  • dermatologic drug
  • hypoglycemic agent
  • immunosuppressive agent
  • leprostatic drug
  • nasal decongestant
  • nephroprotective agent
  • ophthalmology drug
  • renoprotective agent

Pharmacology

Prednisolone is a Corticosteroid. The mechanism of action of prednisolone is as a Corticosteroid Hormone Receptor Agonist.

How it is made

From hydrocortisone by a microbiological process using Corynebacterium simplex, which selectively dehydrogenates cortisol at the 1 and 2 positions.

Preparation: A. Nobile, US 2837464, US 3134718 (1958, 1964, both to Schering)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Prednisolone is traded under.

HS 2937.21Exact HS code

Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…

World exports in 2024
$252M
−5.8% vs 2023, imports $242M
2019 to 2024
Top exporters
  1. China62.1%
  2. Italy9.6%
  3. United States9.4%
Top importers
  1. India * partner reported17.2%
  2. United States10.1%
  3. Italy8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Prednisolone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Prednisolone, based on the data on this page

What is Prednisolone?

Prednisolone is a glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

What is the CAS number of Prednisolone?

The CAS registry number of Prednisolone is 50-24-8. Other or deprecated CAS numbers: 8056-11-9.

What is the molecular formula and weight of Prednisolone?

The molecular formula of Prednisolone is C21H28O5 and its molar mass is 360.45 g/mol.

What is Prednisolone used for?

Medicine, also available in acetate. Commonly used to treat lymphoreticular neoplasms in combination with other drugs ... especially useful in treatment of leukemias and lymphomas of the central nervous system. Therapeutic category: Glucocorticoid. Therapeutic category (veterinary): Glucocorticoid.

Is Prednisolone hazardous?

Prednisolone carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful if inhaled, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Prednisolone?

Prednisolone is usually classified under HS code 293721 (Cortisone, hydrocortisone, prednisone (dehydrocortisone) and prednisolone…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Prednisolone?

CompoundList lists 140 suppliers of Prednisolone in China, United States, India, Bangladesh and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Prednisolone in India?

24 suppliers in India list Prednisolone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Prednisolone?

Suppliers quote Prednisolone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Prednisolone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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