Murcko scaffold
Ring system with 4 rings and 23 atoms
62 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 23
- Chemicals
- 62
- With full pages
- 6
Scaffold SMILES
O=C(Nc1nc2ccccc2s1)c1cc2ccccc2oc1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 62 chemicals
N-(6-Bromo-1,3-benzothiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide
CAS 331652-94-9C17H9BrN2O3S
![N-[(2E)-6-(Dimethylsulfamoyl)-1,3-benzothiazol-2(3H)-ylidene]-2-oxo-2H-chromene-3-carboxamide chemical structure, C19H15N3O5S2, CAS 865592-13-8](/s/YPQVODNQBWMAIH-UHFFFAOYSA-N.svg)
N-[(2E)-6-(Dimethylsulfamoyl)-1,3-benzothiazol-2(3H)-ylidene]-2-oxo-2H-chromene-3-carboxamide
CAS 865592-13-8C19H15N3O5S2
![N-(4,5-Dichlorobenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide chemical structure, C17H8Cl2N2O3S, CAS 868230-64-2](/s/AOCGQUNPOIIUJM-UHFFFAOYSA-N.svg)
N-(4,5-Dichlorobenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide
CAS 868230-64-2C17H8Cl2N2O3S
N-(4,6-Dichloro-3-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-74-8C18H10Cl2N2O3S
2-Oxo-N-(3,5,7-trimethyl-1,3-benzothiazol-2-ylidene)chromene-3-carboxamide
CAS 868369-75-9C20H16N2O3S
2-Oxo-N-(3,4,7-trimethyl-1,3-benzothiazol-2-ylidene)chromene-3-carboxamide
CAS 868369-76-0C20H16N2O3S
N-(4-Methoxy-3,7-dimethyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-77-1C20H16N2O4S
N-(4,7-Dimethoxy-3-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-78-2C20H16N2O5S
N-(7-Chloro-3,4-dimethyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-79-3C19H13ClN2O3S
N-(3-Ethyl-4-methoxy-7-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-80-6C21H18N2O4S
N-(3-Ethyl-4,7-dimethoxy-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868369-81-7C21H18N2O5S
N-(4,6-Difluoro-3-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868375-14-8C18H10F2N2O3S
N-(3-Ethyl-4,6-difluoro-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868375-15-9C19H12F2N2O3S
N-(4-Fluoro-3-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868375-16-0C18H11FN2O3S
N-(3-Ethyl-4-fluoro-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868375-17-1C19H13FN2O3S
![(Z)-N-(3-Allyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide chemical structure, C21H16N2O4S, CAS 868376-43-6](/s/NPFCIGTVRJKGSW-UHFFFAOYSA-N.svg)
(Z)-N-(3-Allyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide
CAS 868376-43-6C21H16N2O4S
![(Z)-N-(3-Allyl-4-ethoxybenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide chemical structure, C22H18N2O4S, CAS 868376-44-7](/s/ZYUCNOVWIRLGBN-UHFFFAOYSA-N.svg)
(Z)-N-(3-Allyl-4-ethoxybenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide
CAS 868376-44-7C22H18N2O4S
N-(5,7-Dimethyl-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868378-01-2C22H16N2O3S
N-(4-Methoxy-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868378-02-3C21H14N2O4S
N-(4-Ethoxy-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868378-03-4C22H16N2O4S
N-(4-Chloro-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide
CAS 868378-05-6C20H11ClN2O3S
![N-(4,6-Dimethylbenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide chemical structure, C19H14N2O3S, CAS 314275-35-9](/s/HNWRMYAVMKEKBT-UHFFFAOYSA-N.svg)
N-(4,6-Dimethylbenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide
CAS 314275-35-9C19H14N2O3S
![(E)-N-(6-Methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide chemical structure, C19H14N2O4S, CAS 681233-07-8](/s/CBUKSUSFWXAKCA-UHFFFAOYSA-N.svg)
(E)-N-(6-Methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide
CAS 681233-07-8C19H14N2O4S
![N-[3-(2-Ethoxyethyl)-6-sulfamoyl-1,3-benzothiazol-2-ylidene]-2-oxochromene-3-carboxamide chemical structure, C21H19N3O6S2, CAS 1164516-85-1](/s/VAYAIIVZRNFOGO-UHFFFAOYSA-N.svg)
N-[3-(2-Ethoxyethyl)-6-sulfamoyl-1,3-benzothiazol-2-ylidene]-2-oxochromene-3-carboxamide
CAS 1164516-85-1C21H19N3O6S2
- (Z)-N-(3-Allyl-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide865176-34-7C20H15N3O5S2
- N-(6-Chloro-3-methyl-1,3-benzothiazol-2-ylidene)-2-oxochromene-3-carboxamide393835-17-1C18H11ClN2O3S
- N-(4-Chlorobenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide476319-51-4C17H9ClN2O3S
- (Z)-Methyl 2-(6-methoxy-2-((2-oxo-2H-chromene-3-carbonyl)imino)benzo[d]thiazol-3(2H)-yl)acetate865199-94-6C21H16N2O6S
- (Z)-N-(3-Methyl-6-(methylsulfonyl)benzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide683238-10-0C19H14N2O5S2
- Ethyl 2-[2-(2-oxochromene-3-carbonyl)imino-6-sulfamoyl-1,3-benzothiazol-3-yl]acetate865247-94-5C21H17N3O7S2
- N-(4,5-Dimethylbenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide888409-65-2C19H14N2O3S
- N-[3-(2-Methoxyethyl)-1,3-benzothiazol-2-ylidene]-2-oxochromene-3-carboxamide864975-58-6C20H16N2O4S
- Ethyl 2-[6-acetamido-2-(2-oxochromene-3-carbonyl)imino-1,3-benzothiazol-3-yl]acetate865248-53-9C23H19N3O6S
- (Z)-N-(6-Bromo-3-(prop-2-yn-1-yl)benzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide865181-34-6C20H11BrN2O3S
- Ethyl 2-[6-nitro-2-(2-oxochromene-3-carbonyl)imino-1,3-benzothiazol-3-yl]acetate865247-26-3C21H15N3O7S
- 2-Oxo-N-(3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)chromene-3-carboxamide865181-06-2C20H12N2O3S
- (Z)-N-(6-Acetamido-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide865161-06-4C22H19N3O5S
- Ethyl 3-(2-methoxy-2-oxoethyl)-2-(2-oxochromene-3-carbonyl)imino-1,3-benzothiazole-6-carboxylate865197-46-2C23H18N2O7S
- (Z)-N-(6-Methoxy-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide865161-46-2C21H18N2O5S
- (Z)-N-(3-(2-Methoxyethyl)-6-nitrobenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide864976-73-8C20H15N3O6S
- Methyl 3-(2-methoxyethyl)-2-(2-oxochromene-3-carbonyl)imino-1,3-benzothiazole-6-carboxylate864975-34-8C22H18N2O6S
- (Z)-N-(3-(2-Methoxyethyl)-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)-2-oxo-2H-chromene-3-carboxamide1164484-28-9C20H17N3O6S2
- Ethyl 2-[2-(2-oxochromene-3-carbonyl)imino-1,3-benzothiazol-3-yl]acetate865246-99-7C21H16N2O5S
- N-(5-Chloro-4-methylbenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide897618-02-9C18H11ClN2O3S
- N-(4,7-Dimethoxy-1,3-benzothiazol-2-yl)-2-oxochromene-3-carboxamide897759-48-7C19H14N2O5S
- N-(4-Ethyl-1,3-benzothiazol-2-yl)-2-oxochromene-3-carboxamide892841-02-0C19H14N2O3S
- N-(3-(Dimethylamino)propyl)-N-(4-fluorobenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide hydrochloride1052532-06-5C22H21ClFN3O3S
- N-(3-(Dimethylamino)propyl)-N-(6-methylbenzo[d]thiazol-2-yl)-2-oxo-2H-chromene-3-carboxamide hydrochloride1052538-19-8C23H24ClN3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1nc2ccccc2s1)c1ccc2ccccc2c123 chemicals
O=C(Nc1nc2ccccc2s1)c1ccc2c(c1)OCCO217 chemicals
O=C(Nc1nc2ccccc2s1)C1COc2ccccc2O112 chemicals
O=C(Nc1nc2ccccc2s1)c1cc(=O)c2ccccc2o110 chemicals
O=C(Nc1cc2c(s1)CNCC2)C1COc2ccccc2O18 chemicals![Scaffold O=C(Nc1nc2ccccc2s1)c1cc2ccccc2[nH]c1=O](/scaffold/JXELEYFOQMVTGD-UHFFFAOYSA-N/structure.svg)
O=C(Nc1nc2ccccc2s1)c1cc2ccccc2[nH]c1=O6 chemicals
O=C(Nc1cc2c(s1)CNCC2)c1ccc2ccccc2c14 chemicals
O=C(Nc1ccc2c(c1)OCCO2)c1cc2ccccc2o14 chemicals
O=C1OC(C(=O)Nc2cc3c(s2)CCCC3)Cc2ccccc214 chemicals
O=C(CN1C(=O)c2ccccc2C1=O)N1CCc2ccccc2C12 chemicals
O=C(Nc1nc2c(s1)CCCC2)C1COc2ccccc2O12 chemicals
O=C(Nc1cc2c(s1)CNCC2)c1ccc2c(c1)OCCO22 chemicals