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Murcko scaffold

Ring system with 4 rings and 22 atoms

91 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 91
With full pages: 12

Scaffold SMILES

O=C(Nc1nc2ccccc2s1)C1COc2ccccc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1nc2ccccc2s1)C1COc2ccccc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

N-(6-Methyl-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C17H14N2O3S, CAS 449168-16-5

N-(6-Methyl-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide

CAS 449168-16-5C₁₇H₁₄N₂O₃S

N-(6-Chloro-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C16H11ClN2O3S, CAS 681166-30-3

N-(6-Chloro-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide

CAS 681166-30-3C₁₆H₁₁ClN₂O₃S

N-(6-Ethoxy-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C18H16N2O4S, CAS 523983-36-0

N-(6-Ethoxy-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide

CAS 523983-36-0C₁₈H₁₆N₂O₄S

N-(6-Methanesulfonyl-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C17H14N2O5S2, CAS 449175-86-4

N-(6-Methanesulfonyl-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide

CAS 449175-86-4C₁₇H₁₄N₂O₅S₂

(Z)-Methyl 2-(2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate chemical structure, C19H17N3O7S2, CAS 1164537-99-8

(Z)-Methyl 2-(2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate

CAS 1164537-99-8C₁₉H₁₇N₃O₇S₂

(Z)-N-(6-Acetamido-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C21H21N3O5S, CAS 865161-17-7

(Z)-N-(6-Acetamido-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 865161-17-7C₂₁H₂₁N₃O₅S

N-(4-Chlorobenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C16H11ClN2O3S, CAS 681167-02-2

N-(4-Chlorobenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 681167-02-2C₁₆H₁₁ClN₂O₃S

N-(4-Methoxybenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C17H14N2O4S, CAS 681166-25-6

N-(4-Methoxybenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 681166-25-6C₁₇H₁₄N₂O₄S

(Z)-Methyl 2-(6-acetamido-2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)benzo[d]thiazol-3(2H)-yl)acetate chemical structure, C21H19N3O6S, CAS 865199-55-9

(Z)-Methyl 2-(6-acetamido-2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)benzo[d]thiazol-3(2H)-yl)acetate

CAS 865199-55-9C₂₁H₁₉N₃O₆S

(Z)-N-(3-(2-Methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H18N2O4S, CAS 864975-68-8

(Z)-N-(3-(2-Methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 864975-68-8C₁₉H₁₈N₂O₄S

Methyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)benzo[d]thiazole-6-carboxylate chemical structure, C18H14N2O5S, CAS 864860-61-7

Methyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)benzo[d]thiazole-6-carboxylate

CAS 864860-61-7C₁₈H₁₄N₂O₅S

N-(4,5-Dimethylbenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H16N2O3S, CAS 946277-03-8

N-(4,5-Dimethylbenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 946277-03-8C₁₈H₁₆N₂O₃S

Ethyl 2-[6-acetamido-2-(2,3-dihydro-1,4-benzodioxine-3-carbonylimino)-1,3-benzothiazol-3-yl]acetate chemical structure, C22H21N3O6S, CAS 865248-59-5

Ethyl 2-[6-acetamido-2-(2,3-dihydro-1,4-benzodioxine-3-carbonylimino)-1,3-benzothiazol-3-yl]acetate

CAS 865248-59-5C₂₂H₂₁N₃O₆S

(Z)-N-(3-(2-Methoxyethyl)-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H19N3O6S2, CAS 1164551-77-2

(Z)-N-(3-(2-Methoxyethyl)-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 1164551-77-2C₁₉H₁₉N₃O₆S₂

(Z)-Ethyl 3-allyl-2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-2,3-dihydrobenzo[d]thiazole-6-carboxylate chemical structure, C22H20N2O5S, CAS 941976-60-9

(Z)-Ethyl 3-allyl-2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-2,3-dihydrobenzo[d]thiazole-6-carboxylate

CAS 941976-60-9C₂₂H₂₀N₂O₅S

Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylimino)-3-(2-methoxy-2-oxoethyl)-1,3-benzothiazole-6-carboxylate chemical structure, C21H18N2O7S, CAS 865197-55-3

Methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylimino)-3-(2-methoxy-2-oxoethyl)-1,3-benzothiazole-6-carboxylate

CAS 865197-55-3C₂₁H₁₈N₂O₇S

N-(4-Methylbenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C17H14N2O3S, CAS 446856-95-7

N-(4-Methylbenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 446856-95-7C₁₇H₁₄N₂O₃S

(E)-N-(6-Bromo-3-methylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C17H13BrN2O3S, CAS 850903-24-1

(E)-N-(6-Bromo-3-methylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 850903-24-1C₁₇H₁₃BrN₂O₃S

(Z)-N-(3-Methyl-6-(methylsulfonyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H16N2O5S2, CAS 442556-75-4

(Z)-N-(3-Methyl-6-(methylsulfonyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 442556-75-4C₁₈H₁₆N₂O₅S₂

N-(3-Prop-2-ynyl-6-sulfamoyl-1,3-benzothiazol-2-ylidene)-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C19H15N3O5S2, CAS 865182-61-2

N-(3-Prop-2-ynyl-6-sulfamoyl-1,3-benzothiazol-2-ylidene)-2,3-dihydro-1,4-benzodioxine-3-carboxamide

CAS 865182-61-2C₁₉H₁₅N₃O₅S₂

(Z)-Methyl 2-(2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-6-methoxybenzo[d]thiazol-3(2H)-yl)acetate chemical structure, C20H18N2O6S, CAS 865200-12-0

(Z)-Methyl 2-(2-((2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)imino)-6-methoxybenzo[d]thiazol-3(2H)-yl)acetate

CAS 865200-12-0C₂₀H₁₈N₂O₆S

N-(6-Nitrobenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C16H11N3O5S, CAS 449176-02-7

N-(6-Nitrobenzo[d]thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 449176-02-7C₁₆H₁₁N₃O₅S

(E)-N-(3,4,6-Trimethylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H18N2O3S, CAS 850903-33-2

(E)-N-(3,4,6-Trimethylbenzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

CAS 850903-33-2C₁₉H₁₈N₂O₃S

N-(6-Methoxy-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C17H14N2O4S, CAS 450392-20-8

N-(6-Methoxy-1,3-benzothiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide

CAS 450392-20-8C₁₇H₁₄N₂O₄S