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Murcko scaffold

Ring system with 2 rings and 10 atoms

107 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
107
With full pages
21
Scaffold SMILES

c1cc2c(s1)CCCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cc2c(s1)CCCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 107 chemicals

Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C12H17NO2S, CAS 40106-13-6
Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 40106-13-6C12H17NO2S
2-Amino-4H,5H,6H,7H,8H-cyclohepta(b)thiophene-3-carbonitrile chemical structure, C10H12N2S, CAS 23917-22-8
2-Amino-4H,5H,6H,7H,8H-cyclohepta(b)thiophene-3-carbonitrile
CAS 23917-22-8C10H12N2S
Ethyl 2-[[2-(dipropylamino)acetyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C20H32N2O3S, CAS 5670-93-9
Ethyl 2-[[2-(dipropylamino)acetyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 5670-93-9C20H32N2O3S
2-Propionamido-N,N-dipropyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C19H30N2O2S, CAS 331718-80-0
2-Propionamido-N,N-dipropyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 331718-80-0C19H30N2O2S
Methyl 2-amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C11H15NO2S, CAS 184174-81-0
Methyl 2-amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxylate
CAS 184174-81-0C11H15NO2S
2-Amino-N-propyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C13H20N2OS, CAS 301321-99-3
2-Amino-N-propyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 301321-99-3C13H20N2OS
2-Amino-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C11H16N2OS, CAS 301321-97-1
2-Amino-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 301321-97-1C11H16N2OS
Ethyl 2-{[N-(propan-2-yl)glycyl]amino}-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C17H26N2O3S, CAS 321530-08-9
Ethyl 2-{[N-(propan-2-yl)glycyl]amino}-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 321530-08-9C17H26N2O3S
4-[(3-Ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobutanoic acid chemical structure, C16H21NO5S, CAS 109164-41-2
4-[(3-Ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobutanoic acid
CAS 109164-41-2C16H21NO5S
5-[(3-Ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-5-oxopentanoic acid chemical structure, C17H23NO5S, CAS 352678-66-1
5-[(3-Ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-5-oxopentanoic acid
CAS 352678-66-1C17H23NO5S
Ethyl 2-(carbamoylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C13H18N2O3S, CAS 309736-19-4
Ethyl 2-(carbamoylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 309736-19-4C13H18N2O3S
2-(Acetylamino)-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C13H18N2O2S, CAS 312949-53-4
2-(Acetylamino)-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 312949-53-4C13H18N2O2S
4-[(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobutanoic acid chemical structure, C14H16N2O3S, CAS 352683-25-1
4-[(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobutanoic acid
CAS 352683-25-1C14H16N2O3S
Isopropyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C13H19NO2S, CAS 351983-32-9
Isopropyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 351983-32-9C13H19NO2S
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)propanamide chemical structure, C13H16N2OS, CAS 362681-00-3
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)propanamide
CAS 362681-00-3C13H16N2OS
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-3-methylbutanamide chemical structure, C15H20N2OS, CAS 332373-58-7
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-3-methylbutanamide
CAS 332373-58-7C15H20N2OS
Ethyl 2-(3-methylbutanamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C17H25NO3S, CAS 496798-16-4
Ethyl 2-(3-methylbutanamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 496798-16-4C17H25NO3S
2-(3-Methylbutanoylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid chemical structure, C15H21NO3S, CAS 342383-88-4
2-(3-Methylbutanoylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid
CAS 342383-88-4C15H21NO3S
5-[(3-Methoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-5-oxopentanoic acid chemical structure, C16H21NO5S, CAS 353774-63-7
5-[(3-Methoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-5-oxopentanoic acid
CAS 353774-63-7C16H21NO5S
Methyl 2-(acetylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C13H17NO3S, CAS 352702-71-7
Methyl 2-(acetylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 352702-71-7C13H17NO3S
2-Amino-4H,5H,6H,7H,8H-cyclohepta(b)thiophene-3-carboxamide chemical structure, C10H14N2OS, CAS 40106-12-5
2-Amino-4H,5H,6H,7H,8H-cyclohepta(b)thiophene-3-carboxamide
CAS 40106-12-5C10H14N2OS
4H-Cyclohepta(b)thiophene-3-carboxylic acid, 5,6,7,8-tetrahydro-2-(((ethylamino)thioxomethyl)amino)-, ethyl ester chemical structure, C15H22N2O2S2, CAS 132605-12-0
4H-Cyclohepta(b)thiophene-3-carboxylic acid, 5,6,7,8-tetrahydro-2-(((ethylamino)thioxomethyl)amino)-, ethyl ester
CAS 132605-12-0C15H22N2O2S2
2-Amino-N-ethyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C12H18N2OS, CAS 301321-98-2
2-Amino-N-ethyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 301321-98-2C12H18N2OS
2-(Acetylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C12H16N2O2S, CAS 302936-19-2
2-(Acetylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 302936-19-2C12H16N2O2S