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Murcko scaffold

Ring system with 5 rings and 25 atoms

52 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
25
Chemicals
52
With full pages
7
Scaffold SMILES

c1ccc(C2=NN3C(C2)c2ccccc2OC3c2ccncc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=NN3C(C2)c2ccccc2OC3c2ccncc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

2-(4-Chlorophenyl)-5-(4-pyridinyl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C21H16ClN3O, CAS 332060-43-2
2-(4-Chlorophenyl)-5-(4-pyridinyl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332060-43-2C21H16ClN3O
9-Chloro-2-(4-methylphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H18ClN3O, CAS 332061-29-7
9-Chloro-2-(4-methylphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332061-29-7C22H18ClN3O
9-Bromo-2-(4-methylphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H18BrN3O, CAS 332062-04-1
9-Bromo-2-(4-methylphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332062-04-1C22H18BrN3O
2-(4-Methoxyphenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine chemical structure, C22H19N3O2, CAS 303060-83-5
2-(4-Methoxyphenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine
CAS 303060-83-5C22H19N3O2
2-(3,4-Dimethoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C23H21N3O3, CAS 330209-51-3
2-(3,4-Dimethoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 330209-51-3C23H21N3O3
9-Chloro-2-(4-methoxyphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H18ClN3O2, CAS 332062-30-3
9-Chloro-2-(4-methoxyphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332062-30-3C22H18ClN3O2
4-[9-Bromo-5-methyl-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazin-2-yl]phenyl methyl ether chemical structure, C23H20BrN3O2, CAS 303059-73-6
4-[9-Bromo-5-methyl-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazin-2-yl]phenyl methyl ether
CAS 303059-73-6C23H20BrN3O2
7,9-Dibromo-2-(3,4-dimethoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C23H19Br2N3O3, CAS 627889-66-1
7,9-Dibromo-2-(3,4-dimethoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 627889-66-1C23H19Br2N3O3
7,9-Dichloro-2-(4-methoxyphenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine chemical structure, C22H17Cl2N3O2, CAS 303059-72-5
7,9-Dichloro-2-(4-methoxyphenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine
CAS 303059-72-5C22H17Cl2N3O2
9-Bromo-2-phenyl-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine chemical structure, C21H16BrN3O, CAS 302559-42-8
9-Bromo-2-phenyl-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
CAS 302559-42-8C21H16BrN3O
7,9-Dibromo-2-(4-methoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H17Br2N3O2, CAS 627889-65-0
7,9-Dibromo-2-(4-methoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 627889-65-0C22H17Br2N3O2
2-(4-Methylphenyl)-5-(4-pyridinyl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H19N3O, CAS 332061-09-3
2-(4-Methylphenyl)-5-(4-pyridinyl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332061-09-3C22H19N3O
7,9-Dibromo-2-(4-methylphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H17Br2N3O, CAS 627889-64-9
7,9-Dibromo-2-(4-methylphenyl)-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 627889-64-9C22H17Br2N3O
7-Ethoxy-2-phenyl-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine chemical structure, C23H21N3O2, CAS 840473-11-2
7-Ethoxy-2-phenyl-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
CAS 840473-11-2C23H21N3O2
9-Chloro-2-phenyl-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C21H16ClN3O, CAS 332060-06-7
9-Chloro-2-phenyl-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 332060-06-7C21H16ClN3O
7,9-Dibromo-2-phenyl-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C21H15Br2N3O, CAS 627889-63-8
7,9-Dibromo-2-phenyl-5-(pyridin-4-yl)-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 627889-63-8C21H15Br2N3O
9-CL-2-(4-F-Phenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine chemical structure, C21H15ClFN3O, CAS 477333-60-1
9-CL-2-(4-F-Phenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine
CAS 477333-60-1C21H15ClFN3O
9-CL-2-(4-F-PH)5-ME-5-(4-Pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine chemical structure, C22H17ClFN3O, CAS 477333-58-7
9-CL-2-(4-F-PH)5-ME-5-(4-Pyridinyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine
CAS 477333-58-7C22H17ClFN3O
4-[9-Bromo-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazin-2-yl]phenyl methyl ether chemical structure, C22H18BrN3O2, CAS 303061-12-3
4-[9-Bromo-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazin-2-yl]phenyl methyl ether
CAS 303061-12-3C22H18BrN3O2
9-Bromo-2-(3-methoxyphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine chemical structure, C22H18BrN3O2, CAS 627889-61-6
9-Bromo-2-(3-methoxyphenyl)-5-pyridin-4-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine
CAS 627889-61-6C22H18BrN3O2
7,9-Dichloro-2-(4-fluorophenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazine chemical structure, C21H14Cl2FN3O, CAS 477333-59-8
7,9-Dichloro-2-(4-fluorophenyl)-5-(4-pyridinyl)-1,10B-dihydropyrazolo[1,5-C][1,3]benzoxazine
CAS 477333-59-8C21H14Cl2FN3O
2-(4-Ethoxyphenyl)-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine chemical structure, C23H21N3O2, CAS 883822-48-8
2-(4-Ethoxyphenyl)-5-pyridin-4-yl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
CAS 883822-48-8C23H21N3O2
3-(9-Chloro-5-(pyridin-4-yl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazin-2-yl)phenol chemical structure, C21H16ClN3O2, CAS 899973-56-9
3-(9-Chloro-5-(pyridin-4-yl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazin-2-yl)phenol
CAS 899973-56-9C21H16ClN3O2
3-[10-Ethoxy-7-(pyridin-4-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C23H21N3O3, CAS 899939-78-7
3-[10-Ethoxy-7-(pyridin-4-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol
CAS 899939-78-7C23H21N3O3