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Murcko scaffold

Ring system with 6 rings and 30 atoms

53 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
30
Chemicals
53
With full pages
5
Scaffold SMILES

O=C1OC2(c3ccccc3Oc3ccc(Nc4ccccc4)cc32)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OC2(c3ccccc3Oc3ccc(Nc4ccccc4)cc32)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(dipentylamino)-3'-methyl-2'-(phenylamino)- chemical structure, C37H40N2O3, CAS 129473-78-5
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(dipentylamino)-3'-methyl-2'-(phenylamino)-
CAS 129473-78-5C37H40N2O3
2'-((4-Chlorophenyl)amino)-6'-(diethylamino)-3'-methylspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one chemical structure, C31H27ClN2O3, CAS 52470-07-2
2'-((4-Chlorophenyl)amino)-6'-(diethylamino)-3'-methylspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
CAS 52470-07-2C31H27ClN2O3
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 6'-(diethylamino)-2'-((3-(trifluoromethyl)phenyl)amino)- chemical structure, C31H25F3N2O3, CAS 68134-61-2
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 6'-(diethylamino)-2'-((3-(trifluoromethyl)phenyl)amino)-
CAS 68134-61-2C31H25F3N2O3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2'-[(2-chlorophenyl)amino]-6'-(diethylamino)- chemical structure, C30H25ClN2O3, CAS 68506-98-9
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2'-[(2-chlorophenyl)amino]-6'-(diethylamino)-
CAS 68506-98-9C30H25ClN2O3
2-Anilino-3-methyl-6-(N-ethyl-N-isoamylamino)fluoran chemical structure, C34H34N2O3, CAS 70516-41-5
2-Anilino-3-methyl-6-(N-ethyl-N-isoamylamino)fluoran
CAS 70516-41-5C34H34N2O3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(hexylmethylamino)-3'-methyl-2'-(phenylamino)- chemical structure, C34H34N2O3, CAS 70516-49-3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(hexylmethylamino)-3'-methyl-2'-(phenylamino)-
CAS 70516-49-3C34H34N2O3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(ethylhexylamino)-3'-methyl-2'-(phenylamino)- chemical structure, C35H36N2O3, CAS 70516-51-7
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6'-(ethylhexylamino)-3'-methyl-2'-(phenylamino)-
CAS 70516-51-7C35H36N2O3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-, ethyl ester chemical structure, C34H32N2O5, CAS 70815-08-6
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-, ethyl ester
CAS 70815-08-6C34H32N2O5
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)- chemical structure, C32H28N2O5, CAS 70815-12-2
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-
CAS 70815-12-2C32H28N2O5
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-, ethyl ester chemical structure, C34H32N2O5, CAS 70815-15-5
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-, ethyl ester
CAS 70815-15-5C34H32N2O5
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)- chemical structure, C32H28N2O5, CAS 70851-43-3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 6'-(diethylamino)-3'-methyl-3-oxo-2'-(phenylamino)-
CAS 70851-43-3C32H28N2O5
3-Diethylamino-6-methyl-7-(2,4-xylidino)fluoran chemical structure, C33H32N2O3, CAS 36431-22-8
3-Diethylamino-6-methyl-7-(2,4-xylidino)fluoran
CAS 36431-22-8C33H32N2O3
6'-(Diethylamino)-2'-(phenylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one chemical structure, C30H26N2O3, CAS 29512-46-7
6'-(Diethylamino)-2'-(phenylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
CAS 29512-46-7C30H26N2O3
2-Anilino-3-methyl-6-diethylaminofluoran chemical structure, C31H28N2O3, CAS 29512-49-0
2-Anilino-3-methyl-6-diethylaminofluoran
CAS 29512-49-0C31H28N2O3
N-[6'-(Diethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-2'-yl]-N-phenylacetamide chemical structure, C32H28N2O4, CAS 34588-29-9
N-[6'-(Diethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-2'-yl]-N-phenylacetamide
CAS 34588-29-9C32H28N2O4
Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-6-carboxylic acid, 6'-(diethylamino)-3-oxo-2'-(phenylamino)- chemical structure, C31H26N2O5
Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-6-carboxylic acid, 6'-(diethylamino)-3-oxo-2'-(phenylamino)-
C31H26N2O5
Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-5-carboxylic acid, 6'-(diethylamino)-3-oxo-2'-(phenylamino)- chemical structure, C31H26N2O5
Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-5-carboxylic acid, 6'-(diethylamino)-3-oxo-2'-(phenylamino)-
C31H26N2O5
Ethyl (3R)-2'-anilino-6'-(diethylamino)-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate chemical structure, C33H30N2O5
Ethyl (3R)-2'-anilino-6'-(diethylamino)-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate
C33H30N2O5
2'-(3-Chloroanilino)-6'-(diethylamino)spiro[2-benzofuran-3,9'-xanthene]-1-one chemical structure, C30H25ClN2O3, CAS 68506-97-8
2'-(3-Chloroanilino)-6'-(diethylamino)spiro[2-benzofuran-3,9'-xanthene]-1-one
CAS 68506-97-8C30H25ClN2O3
6'-(Dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one chemical structure, C35H36N2O3, CAS 89331-94-2
6'-(Dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one
CAS 89331-94-2C35H36N2O3
2'-Anilino-3'-chloro-6'-(diethylamino)spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one chemical structure, C30H25ClN2O3, CAS 85443-45-4
2'-Anilino-3'-chloro-6'-(diethylamino)spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
CAS 85443-45-4C30H25ClN2O3
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-chloro-6'-(dibutylamino)-2'-(phenylamino)- chemical structure, C34H33ClN2O3, CAS 85639-01-6
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-chloro-6'-(dibutylamino)-2'-(phenylamino)-
CAS 85639-01-6C34H33ClN2O3
2'-Anilino-6'-(diethylamino)-3'-methoxyspiro(isobenzofuran-1(3H)-9'(9H)-xanthene)-3-one chemical structure, C31H28N2O4, CAS 73852-10-5
2'-Anilino-6'-(diethylamino)-3'-methoxyspiro(isobenzofuran-1(3H)-9'(9H)-xanthene)-3-one
CAS 73852-10-5C31H28N2O4
2'-Anilino-6'-(dibutylamino)-3'-methoxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one chemical structure, C35H36N2O4, CAS 85223-20-7
2'-Anilino-6'-(dibutylamino)-3'-methoxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
CAS 85223-20-7C35H36N2O4