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Murcko scaffold

Ring system with 3 rings and 18 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
15
With full pages
5
Scaffold SMILES

c1ccc(CN2CCN(c3nccs3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CN2CCN(c3nccs3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

1-[(4-Nitrophenyl)methyl]-4-(1,3-thiazol-2-yl)piperazine chemical structure, C14H16N4O2S, CAS 501081-21-6
1-[(4-Nitrophenyl)methyl]-4-(1,3-thiazol-2-yl)piperazine
CAS 501081-21-6C14H16N4O2S
2-(4-Benzylpiperazino)-1,3-thiazole-5-carbaldehyde chemical structure, C15H17N3OS, CAS 303987-22-6
2-(4-Benzylpiperazino)-1,3-thiazole-5-carbaldehyde
CAS 303987-22-6C15H17N3OS
Methyl 4-amino-2-(4-benzylpiperazino)-1,3-thiazole-5-carboxylate chemical structure, C16H20N4O2S, CAS 343375-51-9
Methyl 4-amino-2-(4-benzylpiperazino)-1,3-thiazole-5-carboxylate
CAS 343375-51-9C16H20N4O2S
4-{[4-(1,3-Thiazol-2-yl)piperazin-1-yl]methyl}aniline chemical structure, C14H18N4S, CAS 1016679-74-5
4-{[4-(1,3-Thiazol-2-yl)piperazin-1-yl]methyl}aniline
CAS 1016679-74-5C14H18N4S
1-[4-(1,1-Dimethylethyl)-2-thiazolyl]-4-(phenylmethyl)piperazine chemical structure, C18H25N3S, CAS 54147-30-7
1-[4-(1,1-Dimethylethyl)-2-thiazolyl]-4-(phenylmethyl)piperazine
CAS 54147-30-7C18H25N3S
4-[[4-(2-Thiazolyl)-1-piperazinyl]methyl]benzenemethanamine chemical structure, C15H20N4S, CAS 1021236-83-8
4-[[4-(2-Thiazolyl)-1-piperazinyl]methyl]benzenemethanamine
CAS 1021236-83-8C15H20N4S
2-(4-(2-(Trifluoromethyl)benzyl)piperazin-1-yl)thiazole-5-carboxamide chemical structure, C16H17F3N4OS, CAS 916888-73-8
2-(4-(2-(Trifluoromethyl)benzyl)piperazin-1-yl)thiazole-5-carboxamide
CAS 916888-73-8C16H17F3N4OS
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-5-yl]ethan-1-one chemical structure, C16H19N3OS, CAS 1478125-58-4
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-5-yl]ethan-1-one
CAS 1478125-58-4C16H19N3OS
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-4-yl]ethan-1-one chemical structure, C16H19N3OS, CAS 1498775-23-7
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-4-yl]ethan-1-one
CAS 1498775-23-7C16H19N3OS
1-Benzyl-4-(5-methyl-1,3-thiazol-2-yl)piperazine chemical structure, C15H19N3S, CAS 2877631-23-5
1-Benzyl-4-(5-methyl-1,3-thiazol-2-yl)piperazine
CAS 2877631-23-5C15H19N3S
Ethyl 4-amino-2-(4-benzylpiperazin-1-yl)-1,3-thiazole-5-carboxylate chemical structure, C17H22N4O2S, CAS 1427461-12-8
Ethyl 4-amino-2-(4-benzylpiperazin-1-yl)-1,3-thiazole-5-carboxylate
CAS 1427461-12-8C17H22N4O2S
1-[(3-Fluoro-4-methoxyphenyl)methyl]-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine chemical structure, C16H17F4N3OS, CAS 2770618-10-3
1-[(3-Fluoro-4-methoxyphenyl)methyl]-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine
CAS 2770618-10-3C16H17F4N3OS
1-Benzyl-4-(5-nitro-1,3-thiazol-2-yl)piperazine chemical structure, C14H16N4O2S, CAS 1857272-32-2
1-Benzyl-4-(5-nitro-1,3-thiazol-2-yl)piperazine
CAS 1857272-32-2C14H16N4O2S
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-4-yl]ethan-1-one hydrobromide chemical structure, C16H20BrN3OS, CAS 2413885-70-6
1-[2-(4-Benzylpiperazin-1-yl)-1,3-thiazol-4-yl]ethan-1-one hydrobromide
CAS 2413885-70-6C16H20BrN3OS
1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine chemical structure, C18H22F3N3O3S, CAS 2742050-23-1
1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
CAS 2742050-23-1C18H22F3N3O3S