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Murcko scaffold

Ring system with 2 rings and 14 atoms

50 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
50
With full pages
4
Scaffold SMILES

c1ccc(CSc2ccncn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2ccncn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

6-Benzylsulfanyl-4-N-methylpyrimidine-2,4-diamine chemical structure, C12H14N4S, CAS 6332-18-9
6-Benzylsulfanyl-4-N-methylpyrimidine-2,4-diamine
CAS 6332-18-9C12H14N4S
6-(Benzylsulfanyl)-n4-ethylpyrimidine-2,4-diamine chemical structure, C13H16N4S, CAS 6940-39-2
6-(Benzylsulfanyl)-n4-ethylpyrimidine-2,4-diamine
CAS 6940-39-2C13H16N4S
6-[(4-Chlorobenzyl)sulfanyl]-n4-methylpyrimidine-2,4-diamine chemical structure, C12H13ClN4S, CAS 6940-40-5
6-[(4-Chlorobenzyl)sulfanyl]-n4-methylpyrimidine-2,4-diamine
CAS 6940-40-5C12H13ClN4S
6-((4-Nitrobenzyl)thio)pyrimidin-4-amine chemical structure, C11H10N4O2S, CAS 6313-85-5
6-((4-Nitrobenzyl)thio)pyrimidin-4-amine
CAS 6313-85-5C11H10N4O2S
4-Chloro-6-[(2,4-dichlorobenzyl)sulfanyl]pyrimidin-2-amine chemical structure, C11H8Cl3N3S, CAS 6307-38-6
4-Chloro-6-[(2,4-dichlorobenzyl)sulfanyl]pyrimidin-2-amine
CAS 6307-38-6C11H8Cl3N3S
4-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-2-amine chemical structure, C12H11Cl2N3S, CAS 7249-21-0
4-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-2-amine
CAS 7249-21-0C12H11Cl2N3S
4-Methyl-6-[(4-nitrophenyl)methylsulfanyl]pyrimidin-2-amine chemical structure, C12H12N4O2S, CAS 6308-31-2
4-Methyl-6-[(4-nitrophenyl)methylsulfanyl]pyrimidin-2-amine
CAS 6308-31-2C12H12N4O2S
4-Benzylsulfanyl-6-methylpyrimidin-2-amine chemical structure, C12H13N3S, CAS 6308-34-5
4-Benzylsulfanyl-6-methylpyrimidin-2-amine
CAS 6308-34-5C12H13N3S
6-Benzylsulfanylpyrimidin-4-amine chemical structure, C11H11N3S, CAS 6310-06-1
6-Benzylsulfanylpyrimidin-4-amine
CAS 6310-06-1C11H11N3S
4-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-6-methyl-2-(methylsulfanyl)pyrimidine chemical structure, C13H12Cl2N2S2, CAS 6310-07-2
4-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-6-methyl-2-(methylsulfanyl)pyrimidine
CAS 6310-07-2C13H12Cl2N2S2
4-{[(2-Chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-2-amine chemical structure, C12H12ClN3S, CAS 6299-21-4
4-{[(2-Chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-2-amine
CAS 6299-21-4C12H12ClN3S
5-Bromo-4-[(2-chlorophenyl)methylsulfanyl]-6-methylpyrimidin-2-amine chemical structure, C12H11BrClN3S, CAS 6299-29-2
5-Bromo-4-[(2-chlorophenyl)methylsulfanyl]-6-methylpyrimidin-2-amine
CAS 6299-29-2C12H11BrClN3S
5-Bromo-4-[(2,4-dichlorobenzyl)sulfanyl]-2-(methylsulfanyl)pyrimidine chemical structure, C12H9BrCl2N2S2, CAS 6341-65-7
5-Bromo-4-[(2,4-dichlorobenzyl)sulfanyl]-2-(methylsulfanyl)pyrimidine
CAS 6341-65-7C12H9BrCl2N2S2
2-Amino-6-(benzylsulfanyl)pyrimidine-4-carboxylic acid chemical structure, C12H11N3O2S, CAS 16558-26-2
2-Amino-6-(benzylsulfanyl)pyrimidine-4-carboxylic acid
CAS 16558-26-2C12H11N3O2S
2-Amino-6-((2-chlorobenzyl)thio)pyrimidine-4-carboxylic acid chemical structure, C12H10ClN3O2S, CAS 16490-13-4
2-Amino-6-((2-chlorobenzyl)thio)pyrimidine-4-carboxylic acid
CAS 16490-13-4C12H10ClN3O2S
N-(4-Amino-6-benzylsulfanylpyrimidin-5-yl)formamide chemical structure, C12H12N4OS, CAS 91560-22-4
N-(4-Amino-6-benzylsulfanylpyrimidin-5-yl)formamide
CAS 91560-22-4C12H12N4OS
2-{[2,5-Diamino-6-(benzylsulfanyl)pyrimidin-4-yl]amino}ethanol chemical structure, C13H17N5OS, CAS 2879-77-8
2-{[2,5-Diamino-6-(benzylsulfanyl)pyrimidin-4-yl]amino}ethanol
CAS 2879-77-8C13H17N5OS
4-(Benzylsulfanyl)-6-hydrazinylpyrimidin-5-amine chemical structure, C11H13N5S, CAS 21308-87-2
4-(Benzylsulfanyl)-6-hydrazinylpyrimidin-5-amine
CAS 21308-87-2C11H13N5S
N-(4-Benzylsulfanyl-6-chloro-5-nitropyrimidin-2-yl)acetamide chemical structure, C13H11ClN4O3S, CAS 51471-47-7
N-(4-Benzylsulfanyl-6-chloro-5-nitropyrimidin-2-yl)acetamide
CAS 51471-47-7C13H11ClN4O3S
N-(4-Amino-6-benzylsulfanylpyrimidin-5-yl)-N-ethylformamide chemical structure, C14H16N4OS, CAS 92296-30-5
N-(4-Amino-6-benzylsulfanylpyrimidin-5-yl)-N-ethylformamide
CAS 92296-30-5C14H16N4OS
2-Amino-4-[(2-chlorobenzyl)sulfanyl]-6-(methylsulfanyl)pyrimidine-5-carbonitrile chemical structure, C13H11ClN4S2, CAS 340807-78-5
2-Amino-4-[(2-chlorobenzyl)sulfanyl]-6-(methylsulfanyl)pyrimidine-5-carbonitrile
CAS 340807-78-5C13H11ClN4S2
4-[(2,4-Dichlorobenzyl)sulfanyl]-2-(methylsulfanyl)pyrimidine chemical structure, C12H10Cl2N2S2, CAS 353260-42-1
4-[(2,4-Dichlorobenzyl)sulfanyl]-2-(methylsulfanyl)pyrimidine
CAS 353260-42-1C12H10Cl2N2S2
{6-[(4-Chlorobenzyl)sulfanyl]-2-methyl-4-pyrimidinyl}methyl methyl ether chemical structure, C14H15ClN2OS, CAS 338747-83-4
{6-[(4-Chlorobenzyl)sulfanyl]-2-methyl-4-pyrimidinyl}methyl methyl ether
CAS 338747-83-4C14H15ClN2OS
N-(5-Methoxy-4-{[3-(trifluoromethyl)benzyl]sulfanyl}-2-pyrimidinyl)-N,N-dimethylamine chemical structure, C15H16F3N3OS, CAS 400084-00-6
N-(5-Methoxy-4-{[3-(trifluoromethyl)benzyl]sulfanyl}-2-pyrimidinyl)-N,N-dimethylamine
CAS 400084-00-6C15H16F3N3OS