Murcko scaffold
2-((1-Benzyl-1H-imidazol-2-yl)thio)-N-phenylacetamide scaffold
115 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 115
- With full pages
- 16
Scaffold SMILES
O=C(CSc1nccn1Cc1ccccc1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 115 chemicals
N-(4-Acetamidophenyl)-2-(1-benzylimidazol-2-yl)sulfanylacetamide
CAS 345991-17-5C20H20N4O2S
2-(1-Benzylimidazol-2-yl)sulfanyl-N-(4-chlorophenyl)acetamide
CAS 690668-09-8C18H16ClN3OS
2-((1-Benzyl-1H-imidazol-2-yl)thio)-N-(4-bromophenyl)acetamide
CAS 893361-43-8C18H16BrN3OS
N-(3-Acetamidophenyl)-2-(1-benzylimidazol-2-yl)sulfanylacetamide
CAS 869346-07-6C20H20N4O2S
![2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C19H15F4N3OS, CAS 869346-26-9](/s/ADJMAKZOITWNQM-UHFFFAOYSA-N.svg)
2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 869346-26-9C19H15F4N3OS
![N-(4-Acetylphenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C20H18FN3O2S, CAS 869346-28-1](/s/MGASOJAZKPUDJP-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-28-1C20H18FN3O2S
![N-(4-Acetamidophenyl)-2-[1-[(4-methylphenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C21H22N4O2S, CAS 869346-49-6](/s/WZZQLZNYKKYRFO-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[1-[(4-methylphenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-49-6C21H22N4O2S
![N-(2,4-Dimethylphenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C21H23N3O2S, CAS 869346-63-4](/s/XGQMHTMTXDDDRN-UHFFFAOYSA-N.svg)
N-(2,4-Dimethylphenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-63-4C21H23N3O2S
![N-(4-Acetylphenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C21H21N3O3S, CAS 869346-67-8](/s/LKMPVYMCMXFUSP-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-67-8C21H21N3O3S
![N-(4-Acetamidophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C21H22N4O3S, CAS 869346-68-9](/s/QAILSXHZDHGBPB-UHFFFAOYSA-N.svg)
N-(4-Acetamidophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-68-9C21H22N4O3S
![N-(3-Acetamidophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C21H22N4O3S, CAS 869346-69-0](/s/RHLFDSIZPBDFJO-UHFFFAOYSA-N.svg)
N-(3-Acetamidophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 869346-69-0C21H22N4O3S
![2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C20H20ClN3O3S, CAS 893378-17-1](/s/RZGJXOYLCJHEME-UHFFFAOYSA-N.svg)
2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2,4-dimethoxyphenyl)acetamide
CAS 893378-17-1C20H20ClN3O3S
![2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C20H20ClN3O3S, CAS 869346-79-2](/s/TZBUBYIYSCTNKP-UHFFFAOYSA-N.svg)
2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2,5-dimethoxyphenyl)acetamide
CAS 869346-79-2C20H20ClN3O3S
![2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(3,4-dimethoxyphenyl)acetamide chemical structure, C20H20ClN3O3S, CAS 893378-32-0](/s/QHNTXRBWUAXLML-UHFFFAOYSA-N.svg)
2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(3,4-dimethoxyphenyl)acetamide
CAS 893378-32-0C20H20ClN3O3S
![Methyl 4-[[2-[1-[(4-chlorophenyl)methyl]imidazol-2-yl]sulfanylacetyl]amino]benzoate chemical structure, C20H18ClN3O3S, CAS 893378-78-4](/s/LEJADQYGFKZJCV-UHFFFAOYSA-N.svg)
Methyl 4-[[2-[1-[(4-chlorophenyl)methyl]imidazol-2-yl]sulfanylacetyl]amino]benzoate
CAS 893378-78-4C20H18ClN3O3S
2-((1-Benzyl-1H-imidazol-2-yl)thio)-N-(2-fluorophenyl)acetamide
CAS 893394-18-8C18H16FN3OS
2-(1-Benzylimidazol-2-yl)sulfanyl-N-(2,4-difluorophenyl)acetamide
CAS 893361-50-7C18H15F2N3OS
2-((1-Benzyl-1H-imidazol-2-yl)thio)-N-(2-methoxyphenyl)acetamide
CAS 893361-73-4C19H19N3O2S
![N-(4-Methoxyphenyl)-2-[[1-(phenylmethyl)-2-imidazolyl]thio]acetamide chemical structure, C19H19N3O2S, CAS 893361-87-0](/s/KRKKIFKFHCKQKL-UHFFFAOYSA-N.svg)
N-(4-Methoxyphenyl)-2-[[1-(phenylmethyl)-2-imidazolyl]thio]acetamide
CAS 893361-87-0C19H19N3O2S
2-(1-Benzylimidazol-2-yl)sulfanyl-N-(2,4-dimethoxyphenyl)acetamide
CAS 893362-08-8C20H21N3O3S
![2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-phenylacetamide chemical structure, C18H16FN3OS, CAS 893363-88-7](/s/FWFZDLAYUYSXHV-UHFFFAOYSA-N.svg)
2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-phenylacetamide
CAS 893363-88-7C18H16FN3OS
![N-(2,4-Difluorophenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C18H14F3N3OS, CAS 893364-99-3](/s/YKVCJPFUPPWCOL-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 893364-99-3C18H14F3N3OS
![N-(3,4-Dichlorophenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide chemical structure, C18H14Cl2FN3OS, CAS 893365-06-5](/s/JSHLVLVVHATFHA-UHFFFAOYSA-N.svg)
N-(3,4-Dichlorophenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide
CAS 893365-06-5C18H14Cl2FN3OS
![2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2-methoxyphenyl)acetamide chemical structure, C19H18FN3O2S, CAS 893365-20-3](/s/BJBPLYZBRSDQTN-UHFFFAOYSA-N.svg)
2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(2-methoxyphenyl)acetamide
CAS 893365-20-3C19H18FN3O2S
- 2-[1-[(4-Fluorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(4-methoxyphenyl)acetamide893365-34-9C19H18FN3O2S
- N-(2,4-Dimethoxyphenyl)-2-[1-[(4-fluorophenyl)methyl]imidazol-2-yl]sulfanylacetamide893365-61-2C20H20FN3O3S
- N-(3,4-Dichlorophenyl)-2-[1-[(4-methylphenyl)methyl]imidazol-2-yl]sulfanylacetamide921079-88-1C19H17Cl2N3OS
- N-(2-Fluorophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide893372-87-7C19H18FN3O2S
- N-(2,4-Difluorophenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide893373-33-6C19H17F2N3O2S
- N-(2-Methoxyphenyl)-2-[1-[(4-methoxyphenyl)methyl]imidazol-2-yl]sulfanylacetamide893373-57-4C20H21N3O3S
- 2-[1-[(4-Chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-(3-methylphenyl)acetamide893376-78-8C19H18ClN3OS
- N-(4-Acetamidophenyl)-2-[1-[(4-chlorophenyl)methyl]imidazol-2-yl]sulfanylacetamide893378-94-4C20H19ClN4O2S
- N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((1-(4-methoxybenzyl)-1H-imidazol-2-yl)thio)acetamide869346-66-7C20H17ClF3N3O2S
- Methyl 4-[2-({1-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-1H-imidazol-2-yl}sulfanyl)acetamido]benzoate899955-89-6C21H20FN3O4S
- Methyl 4-(2-((5-(hydroxymethyl)-1-(4-methylbenzyl)-1H-imidazol-2-yl)thio)acetamido)benzoate899747-98-9C22H23N3O4S
- 2-((5-(Hydroxymethyl)-1-(4-methylbenzyl)-1H-imidazol-2-yl)thio)-N-(3-nitrophenyl)acetamide899955-73-8C20H20N4O4S
- 2-((5-(Hydroxymethyl)-1-(4-methylbenzyl)-1H-imidazol-2-yl)thio)-N-(4-nitrophenyl)acetamide899999-63-4C20H20N4O4S
- 2-((5-(Hydroxymethyl)-1-(4-methylbenzyl)-1H-imidazol-2-yl)thio)-N-methyl-N-phenylacetamide899748-02-8C21H23N3O2S
- 2-((1-Benzyl-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(3-nitrophenyl)acetamide899999-71-4C19H18N4O4S
- 2-((1-Benzyl-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(4-nitrophenyl)acetamide899748-06-2C19H18N4O4S
- 2-((1-Benzyl-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(3,4-dichlorophenyl)acetamide899955-85-2C19H17Cl2N3O2S
- 2-((1-(4-Fluorobenzyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(3-nitrophenyl)acetamide899999-77-0C19H17FN4O4S
- 2-((1-(4-Fluorobenzyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(4-nitrophenyl)acetamide899748-12-0C19H17FN4O4S
- N-(3,4-Dichlorophenyl)-2-((1-(4-fluorobenzyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)acetamide899748-16-4C19H16Cl2FN3O2S
- 2-((5-(Hydroxymethyl)-1-(4-methoxybenzyl)-1H-imidazol-2-yl)thio)-N-(3-nitrophenyl)acetamide899999-85-0C20H20N4O5S
- 2-((5-(Hydroxymethyl)-1-(4-methoxybenzyl)-1H-imidazol-2-yl)thio)-N-(4-nitrophenyl)acetamide899955-95-4C20H20N4O5S
- Methyl 4-(2-((5-(hydroxymethyl)-1-(4-methoxybenzyl)-1H-imidazol-2-yl)thio)acetamido)benzoate899999-87-2C22H23N3O5S
- 2-((1-(4-Chlorobenzyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(3-nitrophenyl)acetamide899955-99-8C19H17ClN4O4S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=S(=O)(NCCc1cn[nH]c1Oc1ccccc1)c1ccccc1](/scaffold/YLVSGZUDHGHTLE-UHFFFAOYSA-N/structure.svg)
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