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Murcko scaffold

Ring system with 4 rings and 26 atoms

114 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
114
With full pages
3
Scaffold SMILES

O=C(CSc1nnc2ccc(-c3ccccc3)nn12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc2ccc(-c3ccccc3)nn12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 114 chemicals

N-(3-Acetylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C22H19N5O2S, CAS 877634-33-8
N-(3-Acetylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 877634-33-8C22H19N5O2S
N-(2-Fluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C19H14FN5OS, CAS 894063-00-4
N-(2-Fluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894063-00-4C19H14FN5OS
N-(4-Fluorophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide chemical structure, C19H14FN5OS, CAS 891117-22-9
N-(4-Fluorophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide
CAS 891117-22-9C19H14FN5OS
N-(3-Chlorophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide chemical structure, C19H14ClN5OS, CAS 891117-28-5
N-(3-Chlorophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide
CAS 891117-28-5C19H14ClN5OS
N-(4-Acetylphenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C21H17N5O2S, CAS 891117-38-7
N-(4-Acetylphenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 891117-38-7C21H17N5O2S
N-(2,4-Difluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C19H13F2N5OS, CAS 894036-80-7
N-(2,4-Difluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894036-80-7C19H13F2N5OS
N-(4-Nitrophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide chemical structure, C19H14N6O3S, CAS 891118-35-7
N-(4-Nitrophenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide
CAS 891118-35-7C19H14N6O3S
N-(2-Methoxy-5-methylphenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C21H19N5O2S, CAS 894037-15-1
N-(2-Methoxy-5-methylphenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894037-15-1C21H19N5O2S
N-(3,4-Difluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C19H13F2N5OS, CAS 894037-22-0
N-(3,4-Difluorophenyl)-2-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894037-22-0C19H13F2N5OS
N-(3-Fluoro-4-methylphenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide chemical structure, C20H16FN5OS, CAS 894037-28-6
N-(3-Fluoro-4-methylphenyl)-2-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}sulfanyl)acetamide
CAS 894037-28-6C20H16FN5OS
N-(2-Fluorophenyl)-2-((6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C20H16FN5O2S, CAS 894051-53-7
N-(2-Fluorophenyl)-2-((6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894051-53-7C20H16FN5O2S
N-(4-Fluorophenyl)-2-{[6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C20H16FN5O2S, CAS 894051-60-6
N-(4-Fluorophenyl)-2-{[6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894051-60-6C20H16FN5O2S
N-(3-Fluorophenyl)-2-{[6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C20H16FN5O2S, CAS 894054-05-8
N-(3-Fluorophenyl)-2-{[6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894054-05-8C20H16FN5O2S
2-((6-(3-Nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)-N-phenylacetamide chemical structure, C19H14N6O3S, CAS 891121-23-6
2-((6-(3-Nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)-N-phenylacetamide
CAS 891121-23-6C19H14N6O3S
N-(4-Ethoxyphenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C22H21N5O2S, CAS 894064-05-2
N-(4-Ethoxyphenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894064-05-2C22H21N5O2S
N-(2-Ethoxyphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C22H21N5O2S, CAS 894064-09-6
N-(2-Ethoxyphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894064-09-6C22H21N5O2S
N-(2-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C20H16FN5OS, CAS 894064-27-8
N-(2-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894064-27-8C20H16FN5OS
N-(4-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C20H16FN5OS, CAS 894064-31-4
N-(4-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894064-31-4C20H16FN5OS
N-(4-Acetylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C22H19N5O2S, CAS 894064-58-5
N-(4-Acetylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894064-58-5C22H19N5O2S
N-(2,4-Difluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C20H15F2N5OS, CAS 894042-77-4
N-(2,4-Difluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894042-77-4C20H15F2N5OS
N-(3-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide chemical structure, C20H16FN5OS, CAS 894042-85-4
N-(3-Fluorophenyl)-2-((6-(p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)acetamide
CAS 894042-85-4C20H16FN5OS
N-(2-Methoxy-5-methylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C22H21N5O2S, CAS 894043-56-2
N-(2-Methoxy-5-methylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894043-56-2C22H21N5O2S
N-(3-Fluoro-4-methylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide chemical structure, C21H18FN5OS, CAS 894043-77-7
N-(3-Fluoro-4-methylphenyl)-2-{[6-(4-methylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}acetamide
CAS 894043-77-7C21H18FN5OS
2-{[6-(4-Ethylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide chemical structure, C21H18FN5OS, CAS 894049-12-8
2-{[6-(4-Ethylphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-N-(2-fluorophenyl)acetamide
CAS 894049-12-8C21H18FN5OS