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Murcko scaffold

8-Phenyl-1,4-dioxaspiro[4,5]decane scaffold

198 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
198
With full pages
2
Scaffold SMILES

c1ccc(C2CCC3(CC2)OCCO3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-Phenyl-1,4-dioxaspiro[4,5]decane page
Murcko scaffold c1ccc(C2CCC3(CC2)OCCO3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 198 chemicals

8-(3,4-Dimethoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C17H21NO4, CAS 61749-06-2
8-(3,4-Dimethoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 61749-06-2C17H21NO4
4-(1,4-Dioxa-8-spiro[4.5]decyl)phenol chemical structure, C14H18O3, CAS 142256-87-9
4-(1,4-Dioxa-8-spiro[4.5]decyl)phenol
CAS 142256-87-9C14H18O3
8-(4-Bromophenyl)-1,4-dioxaspiro[4.5]decan-8-ol chemical structure, C14H17BrO3, CAS 125962-59-6
8-(4-Bromophenyl)-1,4-dioxaspiro[4.5]decan-8-ol
CAS 125962-59-6C14H17BrO3
8-(4-Bromophenyl)-1,4-dioxaspiro[4.5]decane chemical structure, C14H17BrO2, CAS 125962-61-0
8-(4-Bromophenyl)-1,4-dioxaspiro[4.5]decane
CAS 125962-61-0C14H17BrO2
8-Phenyl-1,4-dioxaspiro[4,5]decane chemical structure, C14H18O2, CAS 25163-93-3
8-Phenyl-1,4-dioxaspiro[4,5]decane
CAS 25163-93-3C14H18O2
8-(4-Methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol chemical structure, C15H20O4, CAS 67019-51-6
8-(4-Methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol
CAS 67019-51-6C15H20O4
3-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-benzonitrile chemical structure, C15H17NO3, CAS 540787-52-8
3-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-benzonitrile
CAS 540787-52-8C15H17NO3
(7R,8S)-8-(3,4-Dimethoxyphenyl)-8-(2-propen-1-yl)-1,4-dioxaspiro[4.5]decan-7-ol chemical structure, C19H26O5, CAS 866394-48-1
(7R,8S)-8-(3,4-Dimethoxyphenyl)-8-(2-propen-1-yl)-1,4-dioxaspiro[4.5]decan-7-ol
CAS 866394-48-1C19H26O5
8-(2,5-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol chemical structure, C14H16F2O3, CAS 765913-33-5
8-(2,5-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol
CAS 765913-33-5C14H16F2O3
1,4-Dioxaspiro[4.5]decane-8-carbonitrile, 8-(4-fluorophenyl)- chemical structure, C15H16FNO2, CAS 56327-00-5
1,4-Dioxaspiro[4.5]decane-8-carbonitrile, 8-(4-fluorophenyl)-
CAS 56327-00-5C15H16FNO2
8-(4-Methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C16H19NO3, CAS 5263-42-3
8-(4-Methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 5263-42-3C16H19NO3
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-chlorophenyl)- chemical structure, C15H17ClO4, CAS 56327-02-7
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-chlorophenyl)-
CAS 56327-02-7C15H17ClO4
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-fluorophenyl)- chemical structure, C15H17FO4, CAS 56327-03-8
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-fluorophenyl)-
CAS 56327-03-8C15H17FO4
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-methoxyphenyl)- chemical structure, C16H20O5, CAS 56327-04-9
1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-methoxyphenyl)-
CAS 56327-04-9C16H20O5
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C15H17NO2, CAS 51509-98-9
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 51509-98-9C15H17NO2
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde chemical structure, C15H18O3, CAS 56327-24-3
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde
CAS 56327-24-3C15H18O3
1,4-Dioxaspiro[4.5]decane, 8-methyl-8-phenyl- chemical structure, C15H20O2, CAS 56327-25-4
1,4-Dioxaspiro[4.5]decane, 8-methyl-8-phenyl-
CAS 56327-25-4C15H20O2
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carboxylic acid chemical structure, C15H18O4, CAS 51509-99-0
8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carboxylic acid
CAS 51509-99-0C15H18O4
Ethyl 3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)propanoate chemical structure, C19H26O4, CAS 60693-92-7
Ethyl 3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)propanoate
CAS 60693-92-7C19H26O4
8-(4-Bromophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine chemical structure, C16H22BrNO2, CAS 71368-46-2
8-(4-Bromophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine
CAS 71368-46-2C16H22BrNO2
8-(2-Methylphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C16H19NO2, CAS 65619-10-5
8-(2-Methylphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 65619-10-5C16H19NO2
8-(3-Methylphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C16H19NO2, CAS 65619-70-7
8-(3-Methylphenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 65619-70-7C16H19NO2
8-(2-Chlorophenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile chemical structure, C15H16ClNO2, CAS 65618-89-5
8-(2-Chlorophenyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS 65618-89-5C15H16ClNO2
8-(3-Chlorophenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile chemical structure, C15H16ClNO2, CAS 65619-33-2
8-(3-Chlorophenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile
CAS 65619-33-2C15H16ClNO2