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Murcko scaffold

8-Phenyl-1,4-dioxa-8-azaspiro[4.5]decane scaffold

67 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
67
With full pages
2
Scaffold SMILES

c1ccc(N2CCC3(CC2)OCCO3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-Phenyl-1,4-dioxa-8-azaspiro[4.5]decane page
Murcko scaffold c1ccc(N2CCC3(CC2)OCCO3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 67 chemicals

4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)benzaldehyde chemical structure, C14H17NO3, CAS 79421-40-2
4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)benzaldehyde
CAS 79421-40-2C14H17NO3
8-(4-(Methylsulfonyl)phenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H19NO4S, CAS 116248-03-4
8-(4-(Methylsulfonyl)phenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 116248-03-4C14H19NO4S
8-(4-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H16N2O4, CAS 79421-42-4
8-(4-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 79421-42-4C13H16N2O4
8-(3-Chlorophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H16ClNO2, CAS 634904-77-1
8-(3-Chlorophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 634904-77-1C13H16ClNO2
8-(3-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H16N2O4, CAS 634904-79-3
8-(3-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 634904-79-3C13H16N2O4
8-Phenyl-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H17NO2, CAS 198649-62-6
8-Phenyl-1,4-dioxa-8-azaspiro[4.5]decane
CAS 198649-62-6C13H17NO2
8-(4-Bromophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H16BrNO2, CAS 858516-24-2
8-(4-Bromophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 858516-24-2C13H16BrNO2
Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate chemical structure, C16H21NO4, CAS 79421-38-8
Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate
CAS 79421-38-8C16H21NO4
4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile chemical structure, C14H16N2O2, CAS 79421-39-9
4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile
CAS 79421-39-9C14H16N2O2
1-(4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)ethanone chemical structure, C15H19NO3, CAS 79421-41-3
1-(4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)ethanone
CAS 79421-41-3C15H19NO3
1-[5-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2-nitrophenyl]-1-ethanone chemical structure, C15H18N2O5, CAS 923106-13-2
1-[5-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2-nitrophenyl]-1-ethanone
CAS 923106-13-2C15H18N2O5
8-(2-Methoxyphenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H19NO3, CAS 218610-30-1
8-(2-Methoxyphenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 218610-30-1C14H19NO3
8-(3,5-Difluorophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H15F2NO2, CAS 494861-58-4
8-(3,5-Difluorophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 494861-58-4C13H15F2NO2
2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)benzonitrile chemical structure, C14H16N2O2, CAS 120807-27-4
2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)benzonitrile
CAS 120807-27-4C14H16N2O2
8-(3-Methoxyphenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H19NO3, CAS 169963-58-0
8-(3-Methoxyphenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 169963-58-0C14H19NO3
5-Amino-2-(1,4-dioxa-8-azaspiro[4,5]dec-8-yl)fluorobenzene chemical structure, C13H17FN2O2, CAS 252336-84-8
5-Amino-2-(1,4-dioxa-8-azaspiro[4,5]dec-8-yl)fluorobenzene
CAS 252336-84-8C13H17FN2O2
8-(2-Fluoro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H15FN2O4, CAS 252336-82-6
8-(2-Fluoro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 252336-82-6C13H15FN2O4
8-(2-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H16N2O4, CAS 218610-20-9
8-(2-Nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 218610-20-9C13H16N2O4
4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)aniline chemical structure, C13H18N2O2, CAS 373359-51-4
4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)aniline
CAS 373359-51-4C13H18N2O2
4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)benzylamine chemical structure, C14H20N2O2, CAS 214759-76-9
4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)benzylamine
CAS 214759-76-9C14H20N2O2
8-[4-(Ethylsulfonyl)-2-nitrophenyl]-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C15H20N2O6S, CAS 942474-61-5
8-[4-(Ethylsulfonyl)-2-nitrophenyl]-1,4-dioxa-8-azaspiro[4.5]decane
CAS 942474-61-5C15H20N2O6S
8-(2-Nitro-4-(trifluoromethyl)phenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C14H15F3N2O4, CAS 942474-81-9
8-(2-Nitro-4-(trifluoromethyl)phenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 942474-81-9C14H15F3N2O4
8-(4-Fluoro-2-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H15FN2O4, CAS 914637-75-5
8-(4-Fluoro-2-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 914637-75-5C13H15FN2O4
8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane chemical structure, C13H15ClN2O4, CAS 873537-28-1
8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
CAS 873537-28-1C13H15ClN2O4