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Murcko scaffold

2-Phenyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione scaffold

31 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
18
Chemicals
31
With full pages
4
Scaffold SMILES

O=C1C2C3C=CC(O3)C2C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione page
Murcko scaffold O=C1C2C3C=CC(O3)C2C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

2-Phenyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C14H11NO3, CAS 27742-33-2
2-Phenyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 27742-33-2C14H11NO3
2-(4-Methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C15H13NO4, CAS 43069-77-8
2-(4-Methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 43069-77-8C15H13NO4
Ethyl 4-(1,3-dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)benzoate chemical structure, C17H15NO5, CAS 32620-97-6
Ethyl 4-(1,3-dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)benzoate
CAS 32620-97-6C17H15NO5
(3aS,4R,7S,7aR)-2-Phenyl-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione chemical structure, C14H11NO3, CAS 10039-57-3
(3aS,4R,7S,7aR)-2-Phenyl-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione
CAS 10039-57-3C14H11NO3
4-Methyl-2-(2-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C15H12N2O5, CAS 358731-30-3
4-Methyl-2-(2-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 358731-30-3C15H12N2O5
4-Methyl-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C15H12N2O5, CAS 5377-35-5
4-Methyl-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 5377-35-5C15H12N2O5
4,7-Dimethyl-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H14N2O5, CAS 406222-19-3
4,7-Dimethyl-2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 406222-19-3C16H14N2O5
4-(Hydroxymethyl)-2-(2-methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H15NO5, CAS 329368-26-5
4-(Hydroxymethyl)-2-(2-methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 329368-26-5C16H15NO5
2-(3-Bromophenyl)-4-(hydroxymethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C15H12BrNO4, CAS 339334-81-5
2-(3-Bromophenyl)-4-(hydroxymethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 339334-81-5C15H12BrNO4
2-(4-Methoxyphenyl)-4-methyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H15NO4, CAS 354808-20-1
2-(4-Methoxyphenyl)-4-methyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 354808-20-1C16H15NO4
2-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H11ClF3NO4, CAS 339334-80-4
2-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 339334-80-4C16H11ClF3NO4
2-(2-(Trifluoromethyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C15H10F3NO3, CAS 124003-24-3
2-(2-(Trifluoromethyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 124003-24-3C15H10F3NO3
2-(2-Chlorophenyl)-4-methyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3-dione chemical structure, C15H12ClNO3, CAS 306275-87-6
2-(2-Chlorophenyl)-4-methyl-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3-dione
CAS 306275-87-6C15H12ClNO3
4-Methyl-2-(4-methyl-3-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H14N2O5, CAS 354158-87-5
4-Methyl-2-(4-methyl-3-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 354158-87-5C16H14N2O5
3-[4-(Hydroxymethyl)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl]benzoic acid chemical structure, C16H13NO6, CAS 358731-38-1
3-[4-(Hydroxymethyl)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl]benzoic acid
CAS 358731-38-1C16H13NO6
Methyl 2-chloro-5-(4,7-dimethyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl)benzoate chemical structure, C18H16ClNO5, CAS 352563-17-8
Methyl 2-chloro-5-(4,7-dimethyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl)benzoate
CAS 352563-17-8C18H16ClNO5
4-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindol-2(3H)-yl)phenyl acetate chemical structure, C16H13NO5, CAS 319928-23-9
4-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindol-2(3H)-yl)phenyl acetate
CAS 319928-23-9C16H13NO5
2-(2,3-Dimethylphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione chemical structure, C16H15NO3, CAS 149577-67-3
2-(2,3-Dimethylphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS 149577-67-3C16H15NO3
2-(3-Methoxyphenyl)-4,7-dimethyl-3a,7a-dihydro-4,7-epoxyisoindole-1,3-dione chemical structure, C17H17NO4, CAS 473448-04-3
2-(3-Methoxyphenyl)-4,7-dimethyl-3a,7a-dihydro-4,7-epoxyisoindole-1,3-dione
CAS 473448-04-3C17H17NO4
[2-(3-Nitrophenyl)-1,3-dioxo-1,2,3,3A,7,7A-hexahydro-4H-4,7-epoxyisoindol-4-yl]methylene diacetate chemical structure, C19H16N2O9, CAS 6238-10-4
[2-(3-Nitrophenyl)-1,3-dioxo-1,2,3,3A,7,7A-hexahydro-4H-4,7-epoxyisoindol-4-yl]methylene diacetate
CAS 6238-10-4C19H16N2O9
Methyl 2-{4-[bis(acetyloxy)methyl]-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl}benzoate chemical structure, C21H19NO9, CAS 433265-12-4
Methyl 2-{4-[bis(acetyloxy)methyl]-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl}benzoate
CAS 433265-12-4C21H19NO9
(1,3-Dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindol-4-yl)methylene diacetate chemical structure, C20H16F3NO7, CAS 433264-83-6
(1,3-Dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindol-4-yl)methylene diacetate
CAS 433264-83-6C20H16F3NO7
2-(3-Chloro-4-fluorophenyl)-7-methyl-4,7a-dihydro-3aH-4,7-epoxyisoindole-1,3-dione chemical structure, C15H11ClFNO3, CAS 473803-51-9
2-(3-Chloro-4-fluorophenyl)-7-methyl-4,7a-dihydro-3aH-4,7-epoxyisoindole-1,3-dione
CAS 473803-51-9C15H11ClFNO3
4-(2,4-Dichlorophenyl)-10-oxa-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione chemical structure, C14H9Cl2NO3, CAS 473802-76-5
4-(2,4-Dichlorophenyl)-10-oxa-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione
CAS 473802-76-5C14H9Cl2NO3