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Murcko scaffold

1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylethanone scaffold

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(Cc1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylethanone page
Murcko scaffold O=C(Cc1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylethanone chemical structure, C20H22N2O3, CAS 346704-59-4
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylethanone
CAS 346704-59-4C20H22N2O3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(3,4-dimethoxyphenyl)ethanone chemical structure, C22H26N2O5, CAS 349439-07-2
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(3,4-dimethoxyphenyl)ethanone
CAS 349439-07-2C22H26N2O5
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(2-chloro-6-fluorophenyl)ethanone chemical structure, C20H20ClFN2O3, CAS 825597-37-3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(2-chloro-6-fluorophenyl)ethanone
CAS 825597-37-3C20H20ClFN2O3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone chemical structure, C21H24N2O3, CAS 599163-09-4
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone
CAS 599163-09-4C21H24N2O3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-nitrophenyl)ethanone chemical structure, C20H21N3O5, CAS 349440-41-1
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-nitrophenyl)ethanone
CAS 349440-41-1C20H21N3O5
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylbutan-1-one chemical structure, C22H26N2O3, CAS 349537-75-3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-phenylbutan-1-one
CAS 349537-75-3C22H26N2O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-oxo-1-phenylethyl acetate chemical structure, C22H24N2O5, CAS 500105-28-2
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-oxo-1-phenylethyl acetate
CAS 500105-28-2C22H24N2O5
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-nitrophenyl)propan-1-one chemical structure, C21H23N3O5, CAS 694444-26-3
1-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-nitrophenyl)propan-1-one
CAS 694444-26-3C21H23N3O5
1-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-2-[4-(2-methylpropyl)phenyl]propan-1-one chemical structure, C25H32N2O3, CAS 2549018-57-5
1-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-2-[4-(2-methylpropyl)phenyl]propan-1-one
CAS 2549018-57-5C25H32N2O3