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Murcko scaffold

Ring system with 5 rings and 31 atoms

152 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
31
Chemicals
152
With full pages
13
Scaffold SMILES

O=C(CN1C(=O)C2(SCC(=O)N2c2ccccc2)c2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)C2(SCC(=O)N2c2ccccc2)c2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 152 chemicals

2-{2,4'-Dioxo-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl}-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C25H18F3N3O3S, CAS 894544-42-4
2-{2,4'-Dioxo-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl}-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 894544-42-4C25H18F3N3O3S
N-(2,4-Dimethylphenyl)-2-[3'-(4-methylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide chemical structure, C27H25N3O3S, CAS 894549-77-0
N-(2,4-Dimethylphenyl)-2-[3'-(4-methylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide
CAS 894549-77-0C27H25N3O3S
N-(2-Ethoxyphenyl)-2-(3'-(3-fluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide chemical structure, C26H22FN3O4S, CAS 894551-68-9
N-(2-Ethoxyphenyl)-2-(3'-(3-fluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide
CAS 894551-68-9C26H22FN3O4S
N-(2-Ethyl-6-methylphenyl)-2-(3'-(3-fluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide chemical structure, C27H24FN3O3S, CAS 894552-16-0
N-(2-Ethyl-6-methylphenyl)-2-(3'-(3-fluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide
CAS 894552-16-0C27H24FN3O3S
2-[3'-(4-Fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C27H24FN3O3S, CAS 894553-27-6
2-[3'-(4-Fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide
CAS 894553-27-6C27H24FN3O3S
2-[3'-(4-Fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methylphenyl)acetamide chemical structure, C25H20FN3O3S, CAS 894553-51-6
2-[3'-(4-Fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methylphenyl)acetamide
CAS 894553-51-6C25H20FN3O3S
2-[3'-(3-Chlorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(3,4-dimethylphenyl)acetamide chemical structure, C26H22ClN3O3S, CAS 894556-13-9
2-[3'-(3-Chlorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(3,4-dimethylphenyl)acetamide
CAS 894556-13-9C26H22ClN3O3S
2-(3'-(3,4-Dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C27H25N3O4S, CAS 894557-37-0
2-(3'-(3,4-Dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-methoxyphenyl)acetamide
CAS 894557-37-0C27H25N3O4S
2-[3'-(3,4-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C29H29N3O3S, CAS 894557-63-2
2-[3'-(3,4-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide
CAS 894557-63-2C29H29N3O3S
2-[3'-(3,4-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-fluorophenyl)acetamide chemical structure, C26H22FN3O3S, CAS 894558-19-1
2-[3'-(3,4-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-fluorophenyl)acetamide
CAS 894558-19-1C26H22FN3O3S
2-(3'-(3,5-Dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-ethyl-6-methylphenyl)acetamide chemical structure, C29H29N3O3S, CAS 893786-40-8
2-(3'-(3,5-Dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-ethyl-6-methylphenyl)acetamide
CAS 893786-40-8C29H29N3O3S
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(4-ethylphenyl)acetamide chemical structure, C26H21F2N3O3S, CAS 894562-64-2
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(4-ethylphenyl)acetamide
CAS 894562-64-2C26H21F2N3O3S
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C25H19F2N3O4S, CAS 894562-80-2
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide
CAS 894562-80-2C25H19F2N3O4S
N-(3-Chlorophenyl)-2-[3'-(3,4-difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide chemical structure, C24H16ClF2N3O3S, CAS 894563-44-1
N-(3-Chlorophenyl)-2-[3'-(3,4-difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide
CAS 894563-44-1C24H16ClF2N3O3S
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2,4-dimethylphenyl)acetamide chemical structure, C26H21F2N3O3S, CAS 894563-52-1
2-[3'-(3,4-Difluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2,4-dimethylphenyl)acetamide
CAS 894563-52-1C26H21F2N3O3S
2-(3'-(3,4-Difluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-fluorophenyl)acetamide chemical structure, C24H16F3N3O3S, CAS 894563-60-1
2-(3'-(3,4-Difluorophenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)-N-(2-fluorophenyl)acetamide
CAS 894563-60-1C24H16F3N3O3S
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C27H25N3O4S, CAS 894564-72-8
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(3-methoxyphenyl)acetamide
CAS 894564-72-8C27H25N3O4S
N-(2,4-Difluorophenyl)-2-(3'-(3,5-dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide chemical structure, C26H21F2N3O3S, CAS 894564-88-6
N-(2,4-Difluorophenyl)-2-(3'-(3,5-dimethylphenyl)-2,4'-dioxospiro[indoline-3,2'-thiazolidin]-1-yl)acetamide
CAS 894564-88-6C26H21F2N3O3S
N-(4-Ethoxyphenyl)-2-[3'-(4-fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide chemical structure, C26H22FN3O4S, CAS 894565-51-6
N-(4-Ethoxyphenyl)-2-[3'-(4-fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide
CAS 894565-51-6C26H22FN3O4S
2-[3'-(3-Fluorophenyl)-5-methyl-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C26H22FN3O4S, CAS 899962-77-7
2-[3'-(3-Fluorophenyl)-5-methyl-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide
CAS 899962-77-7C26H22FN3O4S
2-[3'-(4-Fluorophenyl)-5-methyl-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C26H22FN3O4S, CAS 899743-47-6
2-[3'-(4-Fluorophenyl)-5-methyl-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide
CAS 899743-47-6C26H22FN3O4S
N-(2,4-Dimethylphenyl)-2-[3'-(4-fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide chemical structure, C26H22FN3O3S, CAS 894553-91-4
N-(2,4-Dimethylphenyl)-2-[3'-(4-fluorophenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]acetamide
CAS 894553-91-4C26H22FN3O3S
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(4-methylphenyl)acetamide chemical structure, C27H25N3O3S, CAS 894558-95-3
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(4-methylphenyl)acetamide
CAS 894558-95-3C27H25N3O3S
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C27H25N3O4S, CAS 894559-02-5
2-[3'-(3,5-Dimethylphenyl)-2,4'-dioxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-1-yl]-N-(2-methoxyphenyl)acetamide
CAS 894559-02-5C27H25N3O4S