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Murcko scaffold

4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide scaffold

19 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
19
With full pages
4
Scaffold SMILES

O=C(Nc1nc(-c2ccccc2)cs1)c1ccc(N2C(=O)CCC2=O)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide page
Murcko scaffold O=C(Nc1nc(-c2ccccc2)cs1)c1ccc(N2C(=O)CCC2=O)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C22H19N3O5S, CAS 328027-91-4
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 328027-91-4C22H19N3O5S
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-4-phenylthiazole-5-carboxylate chemical structure, C23H19N3O5S, CAS 329906-10-7
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-4-phenylthiazole-5-carboxylate
CAS 329906-10-7C23H19N3O5S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C21H17N3O4S, CAS 325720-22-7
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]benzamide
CAS 325720-22-7C21H17N3O4S
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C22H19N3O3S, CAS 392246-34-3
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 392246-34-3C22H19N3O3S
N-[4-(4-tert-Butylphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C24H23N3O3S, CAS 330200-81-2
N-[4-(4-tert-Butylphenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 330200-81-2C24H23N3O3S
N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C21H14N4O3S, CAS 330200-83-4
N-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 330200-83-4C21H14N4O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C21H17N3O3S, CAS 406194-82-9
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 406194-82-9C21H17N3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C20H14N4O5S, CAS 330200-84-5
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]benzamide
CAS 330200-84-5C20H14N4O5S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H14BrN3O3S, CAS 313405-87-7
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 313405-87-7C20H14BrN3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C23H21N3O3S, CAS 313405-88-8
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]benzamide
CAS 313405-88-8C23H21N3O3S
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H13Cl2N3O3S, CAS 330200-80-1
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 330200-80-1C20H13Cl2N3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C20H14IN3O3S, CAS 330201-05-3
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]benzamide
CAS 330201-05-3C20H14IN3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethoxyphenyl)-5-methyl-1,3-thiazol-2-yl]benzamide chemical structure, C23H21N3O4S, CAS 536732-72-6
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethoxyphenyl)-5-methyl-1,3-thiazol-2-yl]benzamide
CAS 536732-72-6C23H21N3O4S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C20H14FN3O3S, CAS 330200-82-3
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzamide
CAS 330200-82-3C20H14FN3O3S
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H13Cl2N3O3S, CAS 392246-36-5
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 392246-36-5C20H13Cl2N3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide chemical structure, C20H15N3O3S, CAS 476281-72-8
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
CAS 476281-72-8C20H15N3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethoxyphenyl)-1,3-thiazol-2-yl]benzamide chemical structure, C22H19N3O4S, CAS 391896-60-9
4-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethoxyphenyl)-1,3-thiazol-2-yl]benzamide
CAS 391896-60-9C22H19N3O4S
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H14ClN3O3S, CAS 392246-33-2
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 392246-33-2C20H14ClN3O3S
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H13Cl2N3O3S, CAS 477568-94-8
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 477568-94-8C20H13Cl2N3O3S