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Murcko scaffold

Ring system with 4 rings and 25 atoms

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
17
With full pages
1
Scaffold SMILES

O=C(CC1C(=O)N(Cc2ccccc2)c2ccccc21)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)N(Cc2ccccc2)c2ccccc21)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

1-Benzyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C21H17NO3S, CAS 83393-68-4
1-Benzyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 83393-68-4C21H17NO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C21H15BrClNO3S, CAS 355429-00-4
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-1-(4-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 355429-00-4C21H15BrClNO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-1-(2-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C21H15BrClNO3S, CAS 355428-93-2
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-1-(2-chlorobenzyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 355428-93-2C21H15BrClNO3S
1-(2-Chlorobenzyl)-3-hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C21H16ClNO3S, CAS 355428-91-0
1-(2-Chlorobenzyl)-3-hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 355428-91-0C21H16ClNO3S
1-[(4-Chlorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C21H16ClNO3S, CAS 355428-98-7
1-[(4-Chlorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 355428-98-7C21H16ClNO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one chemical structure, C22H18BrNO3S, CAS 356081-16-8
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(2-methylbenzyl)-1,3-dihydro-2H-indol-2-one
CAS 356081-16-8C22H18BrNO3S
1-Benzyl-5-chloro-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C21H15Cl2NO3S, CAS 676612-25-2
1-Benzyl-5-chloro-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 676612-25-2C21H15Cl2NO3S
1-Benzyl-3-[2-(5-bromothiophen-2-yl)-2-oxoethyl]-5-chloro-3-hydroxyindol-2-one chemical structure, C21H15BrClNO3S, CAS 676612-19-4
1-Benzyl-3-[2-(5-bromothiophen-2-yl)-2-oxoethyl]-5-chloro-3-hydroxyindol-2-one
CAS 676612-19-4C21H15BrClNO3S
5-Chloro-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-[(2-methylphenyl)methyl]indol-2-one chemical structure, C22H17Cl2NO3S, CAS 688037-17-4
5-Chloro-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-[(2-methylphenyl)methyl]indol-2-one
CAS 688037-17-4C22H17Cl2NO3S
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-1-[(3,4-dimethoxyphenyl)methyl]-3-hydroxyindol-2-one chemical structure, C23H20ClNO5S, CAS 701946-28-3
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-1-[(3,4-dimethoxyphenyl)methyl]-3-hydroxyindol-2-one
CAS 701946-28-3C23H20ClNO5S
1-[(3,4-Dimethoxyphenyl)methyl]-3-hydroxy-3-[2-(5-methylthiophen-2-yl)-2-oxoethyl]indol-2-one chemical structure, C24H23NO5S, CAS 701970-14-1
1-[(3,4-Dimethoxyphenyl)methyl]-3-hydroxy-3-[2-(5-methylthiophen-2-yl)-2-oxoethyl]indol-2-one
CAS 701970-14-1C24H23NO5S
1-Benzyl-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C21H16ClNO3S, CAS 706776-94-5
1-Benzyl-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 706776-94-5C21H16ClNO3S
1-Benzyl-5-bromo-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C21H16BrNO3S, CAS 689755-50-8
1-Benzyl-5-bromo-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 689755-50-8C21H16BrNO3S
1-[(2-Chlorophenyl)methyl]-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C21H15Cl2NO3S, CAS 690219-66-0
1-[(2-Chlorophenyl)methyl]-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 690219-66-0C21H15Cl2NO3S
5-Chloro-3-hydroxy-1-[(4-methylphenyl)methyl]-3-[2-(5-methylthiophen-2-yl)-2-oxoethyl]indol-2-one chemical structure, C23H20ClNO3S, CAS 690221-70-6
5-Chloro-3-hydroxy-1-[(4-methylphenyl)methyl]-3-[2-(5-methylthiophen-2-yl)-2-oxoethyl]indol-2-one
CAS 690221-70-6C23H20ClNO3S
1-[(3-Fluorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C21H16FNO3S, CAS 838874-64-9
1-[(3-Fluorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 838874-64-9C21H16FNO3S
1-[(2,4-Dimethylphenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C23H21NO3S, CAS 896649-08-4
1-[(2,4-Dimethylphenyl)methyl]-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 896649-08-4C23H21NO3S