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Murcko scaffold

Ring system with 2 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 19
Chemicals: 18
With full pages: 5

Scaffold SMILES

O=C(CSc1ncccn1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1ncccn1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N'-(4-(Dimethylamino)benzylidene)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetohydrazide chemical structure, C17H21N5OS, CAS 305354-33-0

N'-(4-(Dimethylamino)benzylidene)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetohydrazide

CAS 305354-33-0C₁₇H₂₁N₅OS

2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide chemical structure, C16H18N4O2S, CAS 305354-73-8

2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide

CAS 305354-73-8C₁₆H₁₈N₄O₂S

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(4-nitrophenyl)methylideneamino]acetamide chemical structure, C15H15N5O3S, CAS 5637-43-4

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(4-nitrophenyl)methylideneamino]acetamide

CAS 5637-43-4C₁₅H₁₅N₅O₃S

N-[(E)-1-(3,4-Dimethoxyphenyl)ethylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide chemical structure, C18H22N4O3S, CAS 306303-86-6

N-[(E)-1-(3,4-Dimethoxyphenyl)ethylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide

CAS 306303-86-6C₁₈H₂₂N₄O₃S

2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid (1-PH-ethylidene)-hydrazide chemical structure, C16H18N4OS, CAS 60458-66-4

2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid (1-PH-ethylidene)-hydrazide

CAS 60458-66-4C₁₆H₁₈N₄OS

2-((4,6-Dimethyl-2-pyrimidinyl)thio)-N'-(4-isopropylbenzylidene)acetohydrazide chemical structure, C18H22N4OS, CAS 305354-67-0

2-((4,6-Dimethyl-2-pyrimidinyl)thio)-N'-(4-isopropylbenzylidene)acetohydrazide

CAS 305354-67-0C₁₈H₂₂N₄OS

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(Z)-(4-ethylphenyl)methylideneamino]acetamide chemical structure, C17H20N4OS, CAS 306986-94-7

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(Z)-(4-ethylphenyl)methylideneamino]acetamide

CAS 306986-94-7C₁₇H₂₀N₄OS

N-[(E)-(4-Methoxyphenyl)methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C14H14N4O2S, CAS 192565-26-7

N-[(E)-(4-Methoxyphenyl)methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide

CAS 192565-26-7C₁₄H₁₄N₄O₂S

N'-{[4-(Dimethylamino)phenyl]methylidene}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetohydrazide chemical structure, C17H21N5OS

N'-{[4-(Dimethylamino)phenyl]methylidene}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetohydrazide

C₁₇H₂₁N₅OS

2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid benzylidene-hydrazide chemical structure, C15H16N4OS, CAS 60458-57-3

2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid benzylidene-hydrazide

CAS 60458-57-3C₁₅H₁₆N₄OS

N-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide chemical structure, C17H20N4O3S, CAS 1029014-69-4

N-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide

CAS 1029014-69-4C₁₇H₂₀N₄O₃S

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(3-nitrophenyl)methylideneamino]acetamide chemical structure, C15H15N5O3S, CAS 305354-39-6

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(3-nitrophenyl)methylideneamino]acetamide

CAS 305354-39-6C₁₅H₁₅N₅O₃S

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(3-hydroxyphenyl)methylideneamino]acetamide chemical structure, C15H16N4O2S, CAS 305354-49-8

2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(3-hydroxyphenyl)methylideneamino]acetamide

CAS 305354-49-8C₁₅H₁₆N₄O₂S

N'-(2,4-Dichlorobenzylidene)-2-(2-pyrimidinylsulfanyl)acetohydrazide chemical structure, C13H10Cl2N4OS, CAS 339336-05-9

N'-(2,4-Dichlorobenzylidene)-2-(2-pyrimidinylsulfanyl)acetohydrazide

CAS 339336-05-9C₁₃H₁₀Cl₂N₄OS

N-[(E)-(3-Nitrophenyl)methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C13H11N5O3S, CAS 403660-13-9

N-[(E)-(3-Nitrophenyl)methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide

CAS 403660-13-9C₁₃H₁₁N₅O₃S

N'-[(4-Oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-pyrimidin-2-ylsulfanylacetohydrazide chemical structure, C13H12N4O2S, CAS 5631-64-1

N'-[(4-Oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-pyrimidin-2-ylsulfanylacetohydrazide

CAS 5631-64-1C₁₃H₁₂N₄O₂S

N'-[(E)-(4-Hydroxy-3-methoxyphenyl)methylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide chemical structure, C14H14N4O3S, CAS 192565-29-0

N'-[(E)-(4-Hydroxy-3-methoxyphenyl)methylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide

CAS 192565-29-0C₁₄H₁₄N₄O₃S

2-((4,6-Dimethyl-2-pyrimidinyl)thio)N'-(3-ethoxy-2-HO-benzylidene)acetohydrazide chemical structure, C17H20N4O3S, CAS 306986-93-6

2-((4,6-Dimethyl-2-pyrimidinyl)thio)N'-(3-ethoxy-2-HO-benzylidene)acetohydrazide

CAS 306986-93-6C₁₇H₂₀N₄O₃S