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Murcko scaffold

Ring system with 3 rings and 18 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
12
With full pages
3
Scaffold SMILES

O=C(Nc1cccs1)c1ccc2c(c1)CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccs1)c1ccc2c(c1)CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-(3-Cyanothiophen-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide chemical structure, C16H14N2OS, CAS 865545-99-9
N-(3-Cyanothiophen-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide
CAS 865545-99-9C16H14N2OS
2-(5,6,7,8-Tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide chemical structure, C16H16N2O2S, CAS 864940-98-7
2-(5,6,7,8-Tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide
CAS 864940-98-7C16H16N2O2S
N-Methyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide chemical structure, C17H18N2O2S, CAS 864974-69-6
N-Methyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide
CAS 864974-69-6C17H18N2O2S
Ethyl 2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carboxylate chemical structure, C18H19NO3S, CAS 921054-80-0
Ethyl 2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carboxylate
CAS 921054-80-0C18H19NO3S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide chemical structure, C18H18N2OS, CAS 896303-84-7
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide
CAS 896303-84-7C18H18N2OS
4,5-Dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carboxamide chemical structure, C18H20N2O2S, CAS 896309-50-5
4,5-Dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carboxamide
CAS 896309-50-5C18H20N2O2S
N,4,5-trimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 896297-23-7
N,4,5-trimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxamide
CAS 896297-23-7C19H22N2O2S
Methyl (4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carbonyl)carbamate chemical structure, C20H22N2O4S, CAS 896307-53-2
Methyl (4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carbonyl)carbamate
CAS 896307-53-2C20H22N2O4S
Ethyl 4-cyano-3-methyl-5-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-2-carboxylate chemical structure, C20H20N2O3S, CAS 896323-06-1
Ethyl 4-cyano-3-methyl-5-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-2-carboxylate
CAS 896323-06-1C20H20N2O3S
Methyl 4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxylate chemical structure, C19H21NO3S, CAS 882316-36-1
Methyl 4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carbonylamino)thiophene-3-carboxylate
CAS 882316-36-1C19H21NO3S
Ethyl (4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carbonyl)carbamate chemical structure, C21H24N2O4S, CAS 896316-12-4
Ethyl (4,5-dimethyl-2-(5,6,7,8-tetrahydronaphthalene-2-carboxamido)thiophene-3-carbonyl)carbamate
CAS 896316-12-4C21H24N2O4S
2-(5,6,7,8-Tetrahydronaphthalene-2-amido)thiophene-3-carboxylic acid chemical structure, C16H15NO3S, CAS 1099118-88-3
2-(5,6,7,8-Tetrahydronaphthalene-2-amido)thiophene-3-carboxylic acid
CAS 1099118-88-3C16H15NO3S