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Murcko scaffold

Ring system with 6 rings and 33 atoms

97 chemicals on CompoundList share this ring system.

Rings: 6
Scaffold atoms: 33
Chemicals: 97
With full pages: 22

Scaffold SMILES

O=c1c(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)sc2nc(-c3ccccc3)nn12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)sc2nc(-c3ccccc3)nn12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

(5Z)-2-(4-Methoxyphenyl)-5-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C28H21N5O3S, CAS 623935-40-0

(5Z)-2-(4-Methoxyphenyl)-5-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one

CAS 623935-40-0C₂₈H₂₁N₅O₃S

2-[(5Z)-5-{[3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C29H21N5O3S, CAS 384367-28-6

2-[(5Z)-5-{[3-(4-Methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate

CAS 384367-28-6C₂₉H₂₁N₅O₃S

2-[(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C30H23N5O4S, CAS 384376-48-1

2-[(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate

CAS 384376-48-1C₃₀H₂₃N₅O₄S

2-[(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C28H18FN5O3S, CAS 442552-26-3

2-[(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate

CAS 442552-26-3C₂₈H₁₈FN₅O₃S

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(4-ethoxyphenyl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C28H21N5O2S, CAS 623935-42-2

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(4-ethoxyphenyl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one

CAS 623935-42-2C₂₈H₂₁N₅O₂S

(5Z)-2-(4-Ethoxyphenyl)-5-((3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C29H23N5O3S, CAS 623935-44-4

(5Z)-2-(4-Ethoxyphenyl)-5-((3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one

CAS 623935-44-4C₂₉H₂₃N₅O₃S

2-[(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C28H18ClN5O3S, CAS 384350-47-4

2-[(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate

CAS 384350-47-4C₂₈H₁₈ClN₅O₃S

2-{(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylidene]-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl}phenyl acetate chemical structure, C28H19N5O3S, CAS 384353-79-1

2-{(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylidene]-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl}phenyl acetate

CAS 384353-79-1C₂₈H₁₉N₅O₃S

[2-[(5Z)-5-[[3-(4-Bromophenyl)-1-phenylpyrazol-4-yl]methylidene]-6-oxo-[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl] acetate chemical structure, C28H18BrN5O3S, CAS 385391-13-9

[2-[(5Z)-5-[[3-(4-Bromophenyl)-1-phenylpyrazol-4-yl]methylidene]-6-oxo-[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl] acetate

CAS 385391-13-9C₂₈H₁₈BrN₅O₃S

(5Z)-5-{[3-(4-Methoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C29H23N5O2S, CAS 956385-01-6

(5Z)-5-{[3-(4-Methoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956385-01-6C₂₉H₂₃N₅O₂S

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(4-fluorophenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C26H16FN5OS, CAS 957028-79-4

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(4-fluorophenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 957028-79-4C₂₆H₁₆FN₅OS

(5Z)-2-(3,4-Dimethoxyphenyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C29H23N5O3S, CAS 956042-01-6

(5Z)-2-(3,4-Dimethoxyphenyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956042-01-6C₂₉H₂₃N₅O₃S

(5Z)-2-(3,4-Dimethoxyphenyl)-5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene][1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C28H21N5O3S, CAS 956042-02-7

(5Z)-2-(3,4-Dimethoxyphenyl)-5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene][1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956042-02-7C₂₈H₂₁N₅O₃S

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C27H18ClN5OS, CAS 956683-99-1

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956683-99-1C₂₇H₁₈ClN₅OS

(5Z)-2-(2-Methylphenyl)-5-{[1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C30H25N5O2S, CAS 956050-12-7

(5Z)-2-(2-Methylphenyl)-5-{[1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956050-12-7C₃₀H₂₅N₅O₂S

(5Z)-2-(3-Chlorophenyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C27H18ClN5OS, CAS 956325-76-1

(5Z)-2-(3-Chlorophenyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956325-76-1C₂₇H₁₈ClN₅OS

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C27H18FN5OS, CAS 956042-06-1

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956042-06-1C₂₇H₁₈FN₅OS

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(2-methoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C27H19N5O2S, CAS 956042-08-3

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-2-(2-methoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956042-08-3C₂₇H₁₉N₅O₂S

(5Z)-5-{[3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C28H20FN5O2S, CAS 956050-11-6

(5Z)-5-{[3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956050-11-6C₂₈H₂₀FN₅O₂S

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C29H23N5O2S, CAS 956043-70-2

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956043-70-2C₂₉H₂₃N₅O₂S

(5Z)-5-{[3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C28H21N5O2S, CAS 312312-23-5

(5Z)-5-{[3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 312312-23-5C₂₈H₂₁N₅O₂S

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylidene]-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C27H19N5OS, CAS 313049-91-1

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylidene]-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 313049-91-1C₂₇H₁₉N₅OS

(5Z)-2-(4-Fluorophenyl)-5-({1-phenyl-3-[4-(prop-2-en-1-yloxy)phenyl]-1H-pyrazol-4-yl}methylidene)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C29H20FN5O2S, CAS 956684-06-3

(5Z)-2-(4-Fluorophenyl)-5-({1-phenyl-3-[4-(prop-2-en-1-yloxy)phenyl]-1H-pyrazol-4-yl}methylidene)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956684-06-3C₂₉H₂₀FN₅O₂S

(5Z)-5-{[3-(2,5-Dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C29H23N5OS, CAS 956042-13-0

(5Z)-5-{[3-(2,5-Dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(2-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one

CAS 956042-13-0C₂₉H₂₃N₅OS