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Murcko scaffold

Ring system with 4 rings and 24 atoms

49 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
49
With full pages
5
Scaffold SMILES

O=C(CSc1nnc2ccc3ccccc3n12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc2ccc3ccccc3n12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

2-[(5-Methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-phenylacetamide chemical structure, C19H16N4OS, CAS 483292-10-0
2-[(5-Methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-phenylacetamide
CAS 483292-10-0C19H16N4OS
Dimethyl 2-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetyl}amino)terephthalate chemical structure, C23H20N4O5S, CAS 315707-56-3
Dimethyl 2-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetyl}amino)terephthalate
CAS 315707-56-3C23H20N4O5S
Ethyl 4-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetyl}amino)benzoate chemical structure, C22H20N4O3S, CAS 315707-60-9
Ethyl 4-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetyl}amino)benzoate
CAS 315707-60-9C22H20N4O3S
N-(2,5-Dichlorophenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide chemical structure, C19H14Cl2N4OS, CAS 314260-62-3
N-(2,5-Dichlorophenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide
CAS 314260-62-3C19H14Cl2N4OS
2-({5-Methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)-N-(2,4,6-trichlorophenyl)acetamide chemical structure, C19H13Cl3N4OS, CAS 379247-83-3
2-({5-Methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)-N-(2,4,6-trichlorophenyl)acetamide
CAS 379247-83-3C19H13Cl3N4OS
N-(2-Ethoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)acetamide chemical structure, C21H20N4O2S, CAS 379249-08-8
N-(2-Ethoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)acetamide
CAS 379249-08-8C21H20N4O2S
N-(3-Chloro-4-fluorophenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide chemical structure, C19H14ClFN4OS, CAS 379244-49-2
N-(3-Chloro-4-fluorophenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide
CAS 379244-49-2C19H14ClFN4OS
N-(2,6-Dimethylphenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide chemical structure, C21H20N4OS, CAS 315677-23-7
N-(2,6-Dimethylphenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide
CAS 315677-23-7C21H20N4OS
N-(2,5-Dimethylphenyl)-2-((5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio)acetamide chemical structure, C21H20N4OS, CAS 300557-83-9
N-(2,5-Dimethylphenyl)-2-((5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio)acetamide
CAS 300557-83-9C21H20N4OS
N-(4-Ethoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide chemical structure, C21H20N4O2S, CAS 307513-42-4
N-(4-Ethoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide
CAS 307513-42-4C21H20N4O2S
N-(2-Fluorophenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide chemical structure, C19H15FN4OS, CAS 307513-43-5
N-(2-Fluorophenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide
CAS 307513-43-5C19H15FN4OS
2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylsulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C19H13F3N4OS, CAS 671199-22-7
2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylsulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 671199-22-7C19H13F3N4OS
N-(3-Chloro-4-fluorophenyl)-2-([1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)acetamide chemical structure, C18H12ClFN4OS, CAS 671199-23-8
N-(3-Chloro-4-fluorophenyl)-2-([1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)acetamide
CAS 671199-23-8C18H12ClFN4OS
N-(3-Acetylphenyl)-2-([1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)acetamide chemical structure, C20H16N4O2S, CAS 671199-28-3
N-(3-Acetylphenyl)-2-([1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl)acetamide
CAS 671199-28-3C20H16N4O2S
Dimethyl 5-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetyl}amino)isophthalate chemical structure, C23H20N4O5S, CAS 307513-54-8
Dimethyl 5-({[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetyl}amino)isophthalate
CAS 307513-54-8C23H20N4O5S
2-[(5-Methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H15F3N4OS, CAS 314260-30-5
2-[(5-Methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 314260-30-5C20H15F3N4OS
N-(2,6-Dichlorophenyl)-2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide chemical structure, C19H14Cl2N4OS, CAS 315676-51-8
N-(2,6-Dichlorophenyl)-2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide
CAS 315676-51-8C19H14Cl2N4OS
N-(4-Methoxyphenyl)-2-({4-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide chemical structure, C20H18N4O2S, CAS 626205-45-6
N-(4-Methoxyphenyl)-2-({4-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide
CAS 626205-45-6C20H18N4O2S
2-({4-Methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H15F3N4OS, CAS 671199-43-2
2-({4-Methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 671199-43-2C20H15F3N4OS
N-(3-Chloro-4-fluorophenyl)-2-({4-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide chemical structure, C19H14ClFN4OS, CAS 510721-46-7
N-(3-Chloro-4-fluorophenyl)-2-({4-methyl-[1,2,4]triazolo[4,3-A]quinolin-1-YL}sulfanyl)acetamide
CAS 510721-46-7C19H14ClFN4OS
N-(3-Methoxyphenyl)-2-((5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio)acetamide chemical structure, C20H18N4O2S, CAS 483970-54-3
N-(3-Methoxyphenyl)-2-((5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio)acetamide
CAS 483970-54-3C20H18N4O2S
2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylthio)-N-(4-fluorophenyl)acetamide chemical structure, C18H13FN4OS, CAS 671199-16-9
2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylthio)-N-(4-fluorophenyl)acetamide
CAS 671199-16-9C18H13FN4OS
N-(2-Methoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)acetamide chemical structure, C20H18N4O2S, CAS 446851-52-1
N-(2-Methoxyphenyl)-2-({5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}sulfanyl)acetamide
CAS 446851-52-1C20H18N4O2S
N-(4-Fluorophenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide chemical structure, C19H15FN4OS, CAS 304862-45-1
N-(4-Fluorophenyl)-2-[(5-methyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide
CAS 304862-45-1C19H15FN4OS