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Murcko scaffold

1-(1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one scaffold

55 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 55
With full pages: 2

Scaffold SMILES

O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-(1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one page

Murcko scaffold O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

1-(1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C17H23N3O2, CAS 932701-14-9

1-(1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932701-14-9C₁₇H₂₃N₃O₂

Gsk 1034702 chemical structure, C18H24FN3O2, CAS 932373-87-0

CAS 932373-87-0C₁₈H₂₄FN₃O₂

6-Chloro-5-fluoro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C17H21ClFN3O2, CAS 932375-29-6

6-Chloro-5-fluoro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932375-29-6C₁₇H₂₁ClFN₃O₂

4-Fluoro-6-methoxy-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C18H24FN3O3, CAS 932374-01-1

4-Fluoro-6-methoxy-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932374-01-1C₁₈H₂₄FN₃O₃

4,5-Difluoro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C18H23F2N3O2, CAS 932374-02-2

4,5-Difluoro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932374-02-2C₁₈H₂₃F₂N₃O₂

4,5-Difluoro-6-methyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H25F2N3O2, CAS 932374-04-4

4,5-Difluoro-6-methyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932374-04-4C₁₉H₂₅F₂N₃O₂

6-Chloro-4-fluoro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C17H21ClFN3O2, CAS 932373-96-1

6-Chloro-4-fluoro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932373-96-1C₁₇H₂₁ClFN₃O₂

6-Chloro-5-methyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C18H24ClN3O2, CAS 932375-31-0

6-Chloro-5-methyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932375-31-0C₁₈H₂₄ClN₃O₂

5-Methoxy-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H27N3O3, CAS 932375-65-0

5-Methoxy-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932375-65-0C₁₉H₂₇N₃O₃

5-Chloro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C18H24ClN3O2, CAS 932375-66-1

5-Chloro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932375-66-1C₁₈H₂₄ClN₃O₂

5-Fluoro-6-methyl-1-[1-(tetrahydropyran-4-yl)-piperidin-4-yl]-1,3-dihydrobenzimidazol-2-one chemical structure, C18H24FN3O2, CAS 932375-35-4

5-Fluoro-6-methyl-1-[1-(tetrahydropyran-4-yl)-piperidin-4-yl]-1,3-dihydrobenzimidazol-2-one

CAS 932375-35-4C₁₈H₂₄FN₃O₂

5,6-Dimethyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C19H27N3O2, CAS 932375-39-8

5,6-Dimethyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932375-39-8C₁₉H₂₇N₃O₂

5,6-Dichloro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C17H21Cl2N3O2, CAS 932375-43-4

5,6-Dichloro-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932375-43-4C₁₇H₂₁Cl₂N₃O₂

5-Chloro-6-methoxy-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C18H24ClN3O3, CAS 932375-45-6

5-Chloro-6-methoxy-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

CAS 932375-45-6C₁₈H₂₄ClN₃O₃

5-Fluoro-6-methyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H26FN3O2, CAS 932375-72-9

5-Fluoro-6-methyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932375-72-9C₁₉H₂₆FN₃O₂

6-Ethyl-5-fluoro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H26FN3O2, CAS 932375-74-1

6-Ethyl-5-fluoro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932375-74-1C₁₉H₂₆FN₃O₂

5,6-Difluoro-1,3-dihydro-1-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]-2H-benzo[d]imidazol-2-one chemical structure, C17H21F2N3O2, CAS 932375-77-4

5,6-Difluoro-1,3-dihydro-1-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]-2H-benzo[d]imidazol-2-one

CAS 932375-77-4C₁₇H₂₁F₂N₃O₂

2,3-Dihydro-3-methyl-2-oxo-1-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]-1H-benzo[d]imidazol-5-carbonitrile chemical structure, C19H24N4O2, CAS 1026169-68-5

2,3-Dihydro-3-methyl-2-oxo-1-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]-1H-benzo[d]imidazol-5-carbonitrile

CAS 1026169-68-5C₁₉H₂₄N₄O₂

5,6-Dimethyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H29N3O2, CAS 932375-80-9

5,6-Dimethyl-1-(1-(4-methyltetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932375-80-9C₂₀H₂₉N₃O₂

6-Fluoro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C17H22FN3O2, CAS 932701-16-1

6-Fluoro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932701-16-1C₁₇H₂₂FN₃O₂

6-Chloro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C17H22ClN3O2, CAS 932701-18-3

6-Chloro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932701-18-3C₁₇H₂₂ClN₃O₂

6-Methyl-1-[1-(tetrahydropyran-4-yl)-piperidin-4-yl]-1,3-dihydrobenzimidazol-2-one chemical structure, C18H25N3O2, CAS 932701-22-9

6-Methyl-1-[1-(tetrahydropyran-4-yl)-piperidin-4-yl]-1,3-dihydrobenzimidazol-2-one

CAS 932701-22-9C₁₈H₂₅N₃O₂

6-Methoxy-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C18H25N3O3, CAS 932701-25-2

6-Methoxy-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

CAS 932701-25-2C₁₈H₂₅N₃O₃

3-[1-(Oxan-4-yl)piperidin-4-yl]-5-(trifluoromethyl)-1H-benzimidazol-2-one chemical structure, C18H22F3N3O2, CAS 932701-27-4

3-[1-(Oxan-4-yl)piperidin-4-yl]-5-(trifluoromethyl)-1H-benzimidazol-2-one

CAS 932701-27-4C₁₈H₂₂F₃N₃O₂