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Murcko scaffold

Ring system with 4 rings and 27 atoms

54 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
54
With full pages
25
Scaffold SMILES

O=C1C(=O)N(Cc2ccncc2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(Cc2ccncc2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 54 chemicals

3-Hydroxy-5-phenyl-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H22N2O4
3-Hydroxy-5-phenyl-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H22N2O4
5-(3-Fluorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H21FN2O4
5-(3-Fluorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H21FN2O4
4-(3-Fluoro-4-methylbenzoyl)-5-(2-fluorophenyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H18F2N2O3
4-(3-Fluoro-4-methylbenzoyl)-5-(2-fluorophenyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C24H18F2N2O3
3-Hydroxy-5-(4-methylphenyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H24N2O4
3-Hydroxy-5-(4-methylphenyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C27H24N2O4
4-(4-Fluorobenzoyl)-3-hydroxy-5-(4-methylphenyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H19FN2O3
4-(4-Fluorobenzoyl)-3-hydroxy-5-(4-methylphenyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C24H19FN2O3
5-(4-Ethylphenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H26N2O4
5-(4-Ethylphenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C28H26N2O4
5-(4-Fluorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H21FN2O4
5-(4-Fluorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H21FN2O4
4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H29FN2O4
4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C29H29FN2O4
4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(4-propoxyphenyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H25FN2O4
4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(4-propoxyphenyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C27H25FN2O4
3-Hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H28N2O4
3-Hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C29H28N2O4
5-(4-Bromophenyl)-4-(3-fluoro-4-methylbenzoyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H18BrFN2O3
5-(4-Bromophenyl)-4-(3-fluoro-4-methylbenzoyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C24H18BrFN2O3
Methyl 4-[3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-yl]benzoate chemical structure, C26H21FN2O5
Methyl 4-[3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-yl]benzoate
C26H21FN2O5
5-(4-Chlorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H21ClN2O4
5-(4-Chlorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H21ClN2O4
5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H19ClN2O4
5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C24H19ClN2O4
5-(4-Bromophenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione chemical structure, C24H19BrN2O4
5-(4-Bromophenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione
C24H19BrN2O4
4-(4-Chlorobenzoyl)-3-hydroxy-5-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H23ClN2O5
4-(4-Chlorobenzoyl)-3-hydroxy-5-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C27H23ClN2O5
5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione chemical structure, C28H28N2O4
5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione
C28H28N2O4
5-(4-tert-Butylphenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C30H30N2O4
5-(4-tert-Butylphenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C30H30N2O4
3-Hydroxy-4-[(4-methoxyphenyl)carbonyl]-5-[4-(methylethyl)phenyl]-1-(4-pyridyl methyl)-3-pyrrolin-2-one chemical structure, C27H26N2O4, CAS 439947-91-8
3-Hydroxy-4-[(4-methoxyphenyl)carbonyl]-5-[4-(methylethyl)phenyl]-1-(4-pyridyl methyl)-3-pyrrolin-2-one
CAS 439947-91-8C27H26N2O4
4-(3-Fluoro-4-methoxybenzoyl)-5-(2-fluorophenyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H18F2N2O4, CAS 616212-69-2
4-(3-Fluoro-4-methoxybenzoyl)-5-(2-fluorophenyl)-3-hydroxy-1-[(pyridin-4-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 616212-69-2C24H18F2N2O4
(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-phenyl-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione chemical structure, C26H22N2O4, CAS 879189-85-2
(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-phenyl-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione
CAS 879189-85-2C26H22N2O4
(4E)-5-(3-Fluorophenyl)-4-[hydroxy-(4-prop-2-enoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione chemical structure, C26H21FN2O4, CAS 879192-22-0
(4E)-5-(3-Fluorophenyl)-4-[hydroxy-(4-prop-2-enoxyphenyl)methylidene]-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione
CAS 879192-22-0C26H21FN2O4
5-(4-Bromophenyl)-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-1-(4-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H18BrFN2O4, CAS 618074-49-0
5-(4-Bromophenyl)-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-1-(4-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 618074-49-0C24H18BrFN2O4
(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-5-(2-fluorophenyl)-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione chemical structure, C24H18F2N2O3, CAS 879188-54-2
(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-5-(2-fluorophenyl)-1-(pyridin-4-ylmethyl)pyrrolidine-2,3-dione
CAS 879188-54-2C24H18F2N2O3