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Murcko scaffold

Ring system with 4 rings and 27 atoms

26 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 26
With full pages: 3

Scaffold SMILES

O=C1C(=O)N(Cc2cccnc2)C(c2ccncc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=O)N(Cc2cccnc2)C(c2ccncc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

4-[Hydroxy-(4-methylphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C23H19N3O3

4-[Hydroxy-(4-methylphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

C₂₃H₁₉N₃O₃

3-Hydroxy-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H27N3O4

3-Hydroxy-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₇H₂₇N₃O₄

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21N3O4

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₁N₃O₄

3-Hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

3-Hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21N3O3

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₁N₃O₃

4-(4-Butoxybenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

4-(4-Butoxybenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

3-Hydroxy-4-(4-propoxybenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H23N3O4

3-Hydroxy-4-(4-propoxybenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₅H₂₃N₃O₄

3-Hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H21N3O4

3-Hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₅H₂₁N₃O₄

4-(4-Chlorobenzoyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H16ClN3O3, CAS 378212-58-9

4-(4-Chlorobenzoyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 378212-58-9C₂₂H₁₆ClN₃O₃

4-Benzoyl-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H17N3O3, CAS 380583-56-2

4-Benzoyl-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 380583-56-2C₂₂H₁₇N₃O₃

4-(4-Fluorobenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H16FN3O3, CAS 380874-80-6

4-(4-Fluorobenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 380874-80-6C₂₂H₁₆FN₃O₃

3-Hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H27N3O4, CAS 433253-48-6

3-Hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 433253-48-6C₂₇H₂₇N₃O₄

4-(4-Butoxy-3-methylbenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H27N3O4, CAS 459794-00-4

4-(4-Butoxy-3-methylbenzoyl)-3-hydroxy-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 459794-00-4C₂₇H₂₇N₃O₄

3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C25H23N3O4, CAS 384351-31-9

3-Hydroxy-4-(4-isopropoxybenzoyl)-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 384351-31-9C₂₅H₂₃N₃O₄

3-Hydroxy-4-(4-methylbenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H19N3O3, CAS 380155-42-0

3-Hydroxy-4-(4-methylbenzoyl)-1-[(pyridin-3-yl)methyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 380155-42-0C₂₃H₁₉N₃O₃

3-Hydroxy-4-{[2-methyl-4-(2-methylpropoxy)phenyl]carbonyl}-5-(pyridin-4-yl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H27N3O4, CAS 500273-15-4

3-Hydroxy-4-{[2-methyl-4-(2-methylpropoxy)phenyl]carbonyl}-5-(pyridin-4-yl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 500273-15-4C₂₇H₂₇N₃O₄

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H21N3O4, CAS 460046-35-9

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 460046-35-9C₂₄H₂₁N₃O₄

(4E)-4-[Hydroxy-(3-methyl-4-propan-2-yloxyphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C26H25N3O4, CAS 510712-23-9

(4E)-4-[Hydroxy-(3-methyl-4-propan-2-yloxyphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

CAS 510712-23-9C₂₆H₂₅N₃O₄

(4E)-4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C24H21N3O3, CAS 609330-56-5

(4E)-4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

CAS 609330-56-5C₂₄H₂₁N₃O₃

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H18FN3O3, CAS 618073-80-6

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618073-80-6C₂₃H₁₈FN₃O₃

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H18FN3O4, CAS 618074-69-4

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618074-69-4C₂₃H₁₈FN₃O₄

4-(4-Butoxybenzoyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C26H25N3O4, CAS 846586-60-5

4-(4-Butoxybenzoyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 846586-60-5C₂₆H₂₅N₃O₄

(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C25H21N3O4, CAS 848222-32-2

(4E)-4-[Hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

CAS 848222-32-2C₂₅H₂₁N₃O₄