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Murcko scaffold

Ring system with 4 rings and 27 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 18
With full pages: 3

Scaffold SMILES

O=C1C(=O)N(Cc2cccnc2)C(c2cccnc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=O)N(Cc2cccnc2)C(c2cccnc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

4-(2,5-Dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21N3O3

4-(2,5-Dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₁N₃O₃

3-Hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

3-Hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

3-Hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

4-(4-Butoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25N3O4

4-(4-Butoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₅N₃O₄

3-Hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H23N3O4

3-Hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

C₂₅H₂₃N₃O₄

4-(4-Chlorobenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H16ClN3O3, CAS 381693-09-0

4-(4-Chlorobenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 381693-09-0C₂₂H₁₆ClN₃O₃

3-Hydroxy-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H19N3O3, CAS 381202-61-5

3-Hydroxy-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 381202-61-5C₂₃H₁₉N₃O₃

4-(4-Fluorobenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H16FN3O3, CAS 380592-89-2

4-(4-Fluorobenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 380592-89-2C₂₂H₁₆FN₃O₃

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21N3O4, CAS 433255-47-1

3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one

CAS 433255-47-1C₂₄H₂₁N₃O₄

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C25H23N3O4, CAS 370586-32-6

3-Hydroxy-4-(4-isopropoxybenzoyl)-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one

CAS 370586-32-6C₂₅H₂₃N₃O₄

(4E)-4-[Hydroxy-(3-methyl-4-propan-2-yloxyphenyl)methylidene]-5-pyridin-3-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C26H25N3O4, CAS 510712-24-0

(4E)-4-[Hydroxy-(3-methyl-4-propan-2-yloxyphenyl)methylidene]-5-pyridin-3-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

CAS 510712-24-0C₂₆H₂₅N₃O₄

4-(2,5-Dimethyl-benzoyl)-3-hydroxy-5-pyridin-3-yl-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one chemical structure, C24H21N3O3, CAS 609330-57-6

4-(2,5-Dimethyl-benzoyl)-3-hydroxy-5-pyridin-3-yl-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one

CAS 609330-57-6C₂₄H₂₁N₃O₃

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(3-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H18FN3O4, CAS 618074-71-8

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(3-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618074-71-8C₂₃H₁₈FN₃O₄

3-Hydroxy-4-(4-isopropoxy-2-methylbenzoyl)-5-(3-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H25N3O4, CAS 384369-66-8

3-Hydroxy-4-(4-isopropoxy-2-methylbenzoyl)-5-(3-pyridinyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 384369-66-8C₂₆H₂₅N₃O₄

(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-5-pyridin-3-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C26H25N3O4, CAS 844855-09-0

(4E)-4-[Hydroxy-[4-(2-methylpropoxy)phenyl]methylidene]-5-pyridin-3-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione

CAS 844855-09-0C₂₆H₂₅N₃O₄

4-(3,4-Dimethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H21N3O5, CAS 636988-95-9

4-(3,4-Dimethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one

CAS 636988-95-9C₂₄H₂₁N₃O₅

4-(4-Butoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H25N3O4, CAS 847243-34-9

4-(4-Butoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one

CAS 847243-34-9C₂₆H₂₅N₃O₄

3-Hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C25H23N3O4, CAS 844459-22-9

3-Hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one

CAS 844459-22-9C₂₅H₂₃N₃O₄