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Murcko scaffold

Ring system with 2 rings and 16 atoms

13 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
13
With full pages
5
Scaffold SMILES

O=C(CSc1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-(4-Chlorophenyl)sulfanyl-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H17ClN2OS, CAS 358392-93-5
2-(4-Chlorophenyl)sulfanyl-1-(4-methylpiperazin-1-yl)ethanone
CAS 358392-93-5C13H17ClN2OS
Ethyl 4-(2-((4-chlorophenyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C15H19ClN2O3S, CAS 333441-40-0
Ethyl 4-(2-((4-chlorophenyl)thio)acetyl)piperazine-1-carboxylate
CAS 333441-40-0C15H19ClN2O3S
2-[(4-Methylphenyl)sulfanyl]-1-(4-methylpiperazin-1-yl)ethan-1-one chemical structure, C14H20N2OS, CAS 359611-25-9
2-[(4-Methylphenyl)sulfanyl]-1-(4-methylpiperazin-1-yl)ethan-1-one
CAS 359611-25-9C14H20N2OS
Ethyl 4-(2-(p-tolylthio)acetyl)piperazine-1-carboxylate chemical structure, C16H22N2O3S, CAS 358755-58-5
Ethyl 4-(2-(p-tolylthio)acetyl)piperazine-1-carboxylate
CAS 358755-58-5C16H22N2O3S
1-(4-Ethylpiperazin-1-yl)-2-(4-methylphenyl)sulfanylethanone chemical structure, C15H22N2OS, CAS 702649-75-0
1-(4-Ethylpiperazin-1-yl)-2-(4-methylphenyl)sulfanylethanone
CAS 702649-75-0C15H22N2OS
1-(4-Methylsulfonylpiperazin-1-yl)-2-phenylsulfanylethanone chemical structure, C13H18N2O3S2, CAS 895934-43-7
1-(4-Methylsulfonylpiperazin-1-yl)-2-phenylsulfanylethanone
CAS 895934-43-7C13H18N2O3S2
2-Phenylsulfanyl-1-(4-prop-2-enylpiperazin-1-yl)ethanone chemical structure, C15H20N2OS, CAS 898156-57-5
2-Phenylsulfanyl-1-(4-prop-2-enylpiperazin-1-yl)ethanone
CAS 898156-57-5C15H20N2OS
1-(4-Methylpiperazin-1-yl)-2-(phenylsulfanyl)ethanone chemical structure, C13H18N2OS, CAS 72801-07-1
1-(4-Methylpiperazin-1-yl)-2-(phenylsulfanyl)ethanone
CAS 72801-07-1C13H18N2OS
2-[(4-Fluorophenyl)sulfanyl]-1-(4-methylpiperazin-1-yl)ethan-1-one chemical structure, C13H17FN2OS, CAS 1455323-10-0
2-[(4-Fluorophenyl)sulfanyl]-1-(4-methylpiperazin-1-yl)ethan-1-one
CAS 1455323-10-0C13H17FN2OS
2-((4-Fluorophenyl)thio)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethanone hydrochloride chemical structure, C14H17ClF4N2OS, CAS 1351618-00-2
2-((4-Fluorophenyl)thio)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethanone hydrochloride
CAS 1351618-00-2C14H17ClF4N2OS
2-[(3-Methylphenyl)sulfanyl]-1-[4-(prop-2-yn-1-yl)piperazin-1-yl]ethan-1-one chemical structure, C16H20N2OS, CAS 1376219-81-6
2-[(3-Methylphenyl)sulfanyl]-1-[4-(prop-2-yn-1-yl)piperazin-1-yl]ethan-1-one
CAS 1376219-81-6C16H20N2OS
2-[(2-Amino-5-methoxyphenyl)sulfanyl]-1-(piperazin-1-yl)ethan-1-one chemical structure, C13H19N3O2S, CAS 1537578-43-0
2-[(2-Amino-5-methoxyphenyl)sulfanyl]-1-(piperazin-1-yl)ethan-1-one
CAS 1537578-43-0C13H19N3O2S
1-(2-Methylpiperazin-1-yl)-2-(phenylthio)ethan-1-one hydrochloride chemical structure, C13H19ClN2OS, CAS 1582129-48-3
1-(2-Methylpiperazin-1-yl)-2-(phenylthio)ethan-1-one hydrochloride
CAS 1582129-48-3C13H19ClN2OS