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Murcko scaffold

2-(Pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline scaffold

79 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
79
With full pages
4
Scaffold SMILES

c1ccc(N2CCc3ccccc3C2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold c1ccc(N2CCc3ccccc3C2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 79 chemicals

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H12ClF3N2, CAS 338956-56-2
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1,2,3,4-tetrahydroisoquinoline
CAS 338956-56-2C15H12ClF3N2
2-(5-Nitropyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C14H13N3O2, CAS 416885-42-2
2-(5-Nitropyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS 416885-42-2C14H13N3O2
N-(tert-Butyl)-2-(3-nitro-2-pyridinyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide chemical structure, C19H22N4O3, CAS 318256-27-8
N-(tert-Butyl)-2-(3-nitro-2-pyridinyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
CAS 318256-27-8C19H22N4O3
6-(3,4-Dihydro-1H-isoquinolin-2-yl)-N,N-diethylpyridine-3-sulfonamide chemical structure, C18H23N3O2S, CAS 851215-23-1
6-(3,4-Dihydro-1H-isoquinolin-2-yl)-N,N-diethylpyridine-3-sulfonamide
CAS 851215-23-1C18H23N3O2S
6,7-Dimethoxy-2-(3-nitropyridin-2-yl)-3,4-dihydro-1H-isoquinoline chemical structure, C16H17N3O4, CAS 877961-23-4
6,7-Dimethoxy-2-(3-nitropyridin-2-yl)-3,4-dihydro-1H-isoquinoline
CAS 877961-23-4C16H17N3O4
Isoquinoline, 1,2,3,4-tetrahydro-2-(3-nitro-2-pyridinyl)- chemical structure, C14H13N3O2, CAS 140381-70-0
Isoquinoline, 1,2,3,4-tetrahydro-2-(3-nitro-2-pyridinyl)-
CAS 140381-70-0C14H13N3O2
2-((2-(3,4-Dihydroisoquinolin-2(1H)-yl)pyridin-4-yl)amino)ethanol chemical structure, C16H19N3O, CAS 524718-12-5
2-((2-(3,4-Dihydroisoquinolin-2(1H)-yl)pyridin-4-yl)amino)ethanol
CAS 524718-12-5C16H19N3O
2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-4-amine chemical structure, C14H15N3, CAS 524718-15-8
2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-4-amine
CAS 524718-15-8C14H15N3
[4-Amino-6-(3,4-dihydro-1H-isoquinolin-2-yl)-pyridin-2-yl]-methanol chemical structure, C15H17N3O, CAS 524717-74-6
[4-Amino-6-(3,4-dihydro-1H-isoquinolin-2-yl)-pyridin-2-yl]-methanol
CAS 524717-74-6C15H17N3O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-6-methyl-pyridin-4-ylamine chemical structure, C15H17N3, CAS 524717-70-2
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-6-methyl-pyridin-4-ylamine
CAS 524717-70-2C15H17N3
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-6-ethyl-pyridin-4-ylamine chemical structure, C16H19N3, CAS 524717-72-4
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-6-ethyl-pyridin-4-ylamine
CAS 524717-72-4C16H19N3
[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-pyridin-4-yl]-dimethyl-amine chemical structure, C16H19N3, CAS 524717-82-6
[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-pyridin-4-yl]-dimethyl-amine
CAS 524717-82-6C16H19N3
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-methyl-pyridin-4-ylamine chemical structure, C15H17N3, CAS 524717-68-8
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-methyl-pyridin-4-ylamine
CAS 524717-68-8C15H17N3
2-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinamine chemical structure, C14H15N3, CAS 524718-18-1
2-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinamine
CAS 524718-18-1C14H15N3
6-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinamine chemical structure, C14H15N3, CAS 553679-55-3
6-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinamine
CAS 553679-55-3C14H15N3
{2-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinyl}methanamine chemical structure, C15H17N3, CAS 954257-49-9
{2-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-pyridinyl}methanamine
CAS 954257-49-9C15H17N3
[6-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-3-yl]methanamine chemical structure, C15H17N3, CAS 954269-06-8
[6-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-3-yl]methanamine
CAS 954269-06-8C15H17N3
2-(3,4-Dihydroisoquinolin-2(1H)-YL)nicotinonitrile chemical structure, C15H13N3, CAS 945347-37-5
2-(3,4-Dihydroisoquinolin-2(1H)-YL)nicotinonitrile
CAS 945347-37-5C15H13N3
2-[3,4-Dihydro-2(1H)-isoquinolinyl]nicotinic acid chemical structure, C15H14N2O2, CAS 250739-09-4
2-[3,4-Dihydro-2(1H)-isoquinolinyl]nicotinic acid
CAS 250739-09-4C15H14N2O2
Ethyl 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)nicotinate chemical structure, C17H18N2O2, CAS 250739-08-3
Ethyl 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)nicotinate
CAS 250739-08-3C17H18N2O2
2-(4-Methylpyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H16N2, CAS 553679-56-4
2-(4-Methylpyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS 553679-56-4C15H16N2
2-(3,4-Dihydro-2(1H)-isoquinolinyl)-N-ethyl-4-pyridinamine chemical structure, C16H19N3, CAS 524717-86-0
2-(3,4-Dihydro-2(1H)-isoquinolinyl)-N-ethyl-4-pyridinamine
CAS 524717-86-0C16H19N3
N-[2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-4-yl]acetamide chemical structure, C16H17N3O, CAS 524718-17-0
N-[2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-4-yl]acetamide
CAS 524718-17-0C16H17N3O
2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)pyridine-4-carbonitrile chemical structure, C17H17N3O2, CAS 1016784-18-1
2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)pyridine-4-carbonitrile
CAS 1016784-18-1C17H17N3O2