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Murcko scaffold

Ring system with 4 rings and 25 atoms

92 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
92
With full pages
5
Scaffold SMILES

O=c1c(-c2ccccc2)coc2cc(OCc3ccccc3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(-c2ccccc2)coc2cc(OCc3ccccc3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 92 chemicals

7-[(2-Fluorophenyl)methoxy]-3-phenylchromen-4-one chemical structure, C22H15FO3, CAS 686283-54-5
7-[(2-Fluorophenyl)methoxy]-3-phenylchromen-4-one
CAS 686283-54-5C22H15FO3
7-[(2-Methylphenyl)methoxy]-3-phenylchromen-4-one chemical structure, C23H18O3, CAS 773150-67-7
7-[(2-Methylphenyl)methoxy]-3-phenylchromen-4-one
CAS 773150-67-7C23H18O3
7-[(4-Methylphenyl)methoxy]-3-phenylchromen-4-one chemical structure, C23H18O3, CAS 449738-91-4
7-[(4-Methylphenyl)methoxy]-3-phenylchromen-4-one
CAS 449738-91-4C23H18O3
3-(2-Methoxyphenyl)-7-[(3-methylphenyl)methoxy]chromen-4-one chemical structure, C24H20O4, CAS 316127-07-8
3-(2-Methoxyphenyl)-7-[(3-methylphenyl)methoxy]chromen-4-one
CAS 316127-07-8C24H20O4
3-(2-Methoxyphenyl)-7-[(4-methylphenyl)methoxy]chromen-4-one chemical structure, C24H20O4, CAS 329224-97-7
3-(2-Methoxyphenyl)-7-[(4-methylphenyl)methoxy]chromen-4-one
CAS 329224-97-7C24H20O4
Ethyl 3-(4-methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]-4-oxochromene-2-carboxylate chemical structure, C27H24O7, CAS 610751-63-8
Ethyl 3-(4-methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]-4-oxochromene-2-carboxylate
CAS 610751-63-8C27H24O7
7-[(2-Fluorophenyl)methoxy]-3-(2-methoxyphenyl)chromen-4-one chemical structure, C23H17FO4, CAS 610750-34-0
7-[(2-Fluorophenyl)methoxy]-3-(2-methoxyphenyl)chromen-4-one
CAS 610750-34-0C23H17FO4
Ethyl 7-[(2-fluorophenyl)methoxy]-3-(4-methoxyphenyl)-4-oxochromene-2-carboxylate chemical structure, C26H21FO6, CAS 578698-36-9
Ethyl 7-[(2-fluorophenyl)methoxy]-3-(4-methoxyphenyl)-4-oxochromene-2-carboxylate
CAS 578698-36-9C26H21FO6
Ethyl 3-(3,4-dimethoxyphenyl)-7-[(4-methoxycarbonylphenyl)methoxy]-4-oxochromene-2-carboxylate chemical structure, C29H26O9, CAS 610751-29-6
Ethyl 3-(3,4-dimethoxyphenyl)-7-[(4-methoxycarbonylphenyl)methoxy]-4-oxochromene-2-carboxylate
CAS 610751-29-6C29H26O9
7-(Benzyloxy)-3-(2-methoxyphenyl)-4H-chromen-4-one chemical structure, C23H18O4, CAS 303121-62-2
7-(Benzyloxy)-3-(2-methoxyphenyl)-4H-chromen-4-one
CAS 303121-62-2C23H18O4
7-((4-Fluorobenzyl)oxy)-3-(2-methoxyphenyl)-4H-chromen-4-one chemical structure, C23H17FO4, CAS 420833-56-3
7-((4-Fluorobenzyl)oxy)-3-(2-methoxyphenyl)-4H-chromen-4-one
CAS 420833-56-3C23H17FO4
Ethyl 3-(3,4-dimethoxyphenyl)-7-((2-fluorobenzyl)oxy)-4-oxo-4H-chromene-2-carboxylate chemical structure, C27H23FO7, CAS 610750-37-3
Ethyl 3-(3,4-dimethoxyphenyl)-7-((2-fluorobenzyl)oxy)-4-oxo-4H-chromene-2-carboxylate
CAS 610750-37-3C27H23FO7
3-(4-Methoxyphenyl)-7-[(4-methoxyphenyl)methoxy]-2-methylchromen-4-one chemical structure, C25H22O5, CAS 610751-96-7
3-(4-Methoxyphenyl)-7-[(4-methoxyphenyl)methoxy]-2-methylchromen-4-one
CAS 610751-96-7C25H22O5
3-(3,4-Dimethoxyphenyl)-2-methyl-7-[(4-nitrophenyl)methoxy]chromen-4-one chemical structure, C25H21NO7, CAS 610751-12-7
3-(3,4-Dimethoxyphenyl)-2-methyl-7-[(4-nitrophenyl)methoxy]chromen-4-one
CAS 610751-12-7C25H21NO7
7-((4-Methoxybenzyl)oxy)-3-(2-methoxyphenyl)-4H-chromen-4-one chemical structure, C24H20O5, CAS 610751-95-6
7-((4-Methoxybenzyl)oxy)-3-(2-methoxyphenyl)-4H-chromen-4-one
CAS 610751-95-6C24H20O5
3-(2-Methoxyphenyl)-2-methyl-7-phenylmethoxychromen-4-one chemical structure, C24H20O4, CAS 610760-85-5
3-(2-Methoxyphenyl)-2-methyl-7-phenylmethoxychromen-4-one
CAS 610760-85-5C24H20O4
3-(2-Methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]chromen-4-one chemical structure, C24H20O5, CAS 610751-59-2
3-(2-Methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]chromen-4-one
CAS 610751-59-2C24H20O5
3-(2-Methoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one chemical structure, C23H17NO6, CAS 610751-10-5
3-(2-Methoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one
CAS 610751-10-5C23H17NO6
3-(4-Methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]-2-methylchromen-4-one chemical structure, C25H22O5, CAS 610751-60-5
3-(4-Methoxyphenyl)-7-[(3-methoxyphenyl)methoxy]-2-methylchromen-4-one
CAS 610751-60-5C25H22O5
Ethyl 3-(3,4-dimethoxyphenyl)-7-[(4-methoxyphenyl)methoxy]-4-oxochromene-2-carboxylate chemical structure, C28H26O8, CAS 610751-98-9
Ethyl 3-(3,4-dimethoxyphenyl)-7-[(4-methoxyphenyl)methoxy]-4-oxochromene-2-carboxylate
CAS 610751-98-9C28H26O8
3-(4-Methoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one chemical structure, C23H17NO6, CAS 714931-25-6
3-(4-Methoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one
CAS 714931-25-6C23H17NO6
3-(3,4-Dimethoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one chemical structure, C24H19NO7, CAS 714938-00-8
3-(3,4-Dimethoxyphenyl)-7-[(4-nitrophenyl)methoxy]chromen-4-one
CAS 714938-00-8C24H19NO7
3-(3,4-Dimethoxyphenyl)-7-((4-methoxybenzyl)oxy)-2-methyl-4H-chromen-4-one chemical structure, C26H24O6, CAS 610751-97-8
3-(3,4-Dimethoxyphenyl)-7-((4-methoxybenzyl)oxy)-2-methyl-4H-chromen-4-one
CAS 610751-97-8C26H24O6
7-(Benzyloxy)-3-(4-methoxyphenyl)-2-methyl-4H-chromen-4-one chemical structure, C24H20O4, CAS 610760-86-6
7-(Benzyloxy)-3-(4-methoxyphenyl)-2-methyl-4H-chromen-4-one
CAS 610760-86-6C24H20O4