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Murcko scaffold

2H,3H,5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)piperazin-3-one scaffold

26 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
26
With full pages
6
Scaffold SMILES

O=c1[nH]nc2n1CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2H,3H,5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)piperazin-3-one page
Murcko scaffold O=c1[nH]nc2n1CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

3-Oxo-2,3,5,6,7,8-hexahydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid chemical structure, C6H8N4O3, CAS 144888-68-6
3-Oxo-2,3,5,6,7,8-hexahydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid
CAS 144888-68-6C6H8N4O3
2H,3H,5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)piperazin-3-one chemical structure, C5H8N4O, CAS 914654-93-6
2H,3H,5H,6H,7H,8H-(1,2,4)Triazolo(4,3-a)piperazin-3-one
CAS 914654-93-6C5H8N4O
tert-Butyl 3-oxo-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxylate chemical structure, C10H16N4O3, CAS 1182359-42-7
tert-Butyl 3-oxo-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxylate
CAS 1182359-42-7C10H16N4O3
2-Propyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one chemical structure, C8H14N4O, CAS 1515653-42-5
2-Propyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one
CAS 1515653-42-5C8H14N4O
2-(2,2-Difluoroethyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one chemical structure, C7H10F2N4O, CAS 1498956-59-4
2-(2,2-Difluoroethyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one
CAS 1498956-59-4C7H10F2N4O
2-(2-Methylpropyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one chemical structure, C9H16N4O, CAS 1504331-06-9
2-(2-Methylpropyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one
CAS 1504331-06-9C9H16N4O
2-Butyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one chemical structure, C9H16N4O, CAS 1508171-30-9
2-Butyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one
CAS 1508171-30-9C9H16N4O
N,N-Dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide chemical structure, C9H15N5O2, CAS 1541606-87-4
N,N-Dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide
CAS 1541606-87-4C9H15N5O2
2-Methyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one chemical structure, C6H10N4O, CAS 1423026-73-6
2-Methyl-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-3-one
CAS 1423026-73-6C6H10N4O
2-Ethyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyrazin-3(2H)-one chemical structure, C7H12N4O, CAS 1519980-61-0
2-Ethyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyrazin-3(2H)-one
CAS 1519980-61-0C7H12N4O
tert-Butyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylate chemical structure, C10H16N4O3, CAS 1803562-70-0
tert-Butyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylate
CAS 1803562-70-0C10H16N4O3
N,N-Dimethyl-2-[3-oxo-7-(prop-2-enoyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl]acetamide chemical structure, C12H17N5O3, CAS 2109146-24-7
N,N-Dimethyl-2-[3-oxo-7-(prop-2-enoyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl]acetamide
CAS 2109146-24-7C12H17N5O3
Ethyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylate chemical structure, C8H12N4O3, CAS 144888-76-6
Ethyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylate
CAS 144888-76-6C8H12N4O3
2-Methyl-2H,3H,5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazin-3-one hydrochloride chemical structure, C6H11ClN4O, CAS 2137895-63-5
2-Methyl-2H,3H,5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazin-3-one hydrochloride
CAS 2137895-63-5C6H11ClN4O
5H,6H,7H,8H-[1,2,4]Triazolo[4,3-a]pyrazin-3-ol hydrochloride chemical structure, C5H9ClN4O, CAS 2173992-42-0
5H,6H,7H,8H-[1,2,4]Triazolo[4,3-a]pyrazin-3-ol hydrochloride
CAS 2173992-42-0C5H9ClN4O
2-[7-(2-Chloropropanoyl)-3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-2-yl]-N,N-dimethylacetamide chemical structure, C12H18ClN5O3, CAS 2411299-82-4
2-[7-(2-Chloropropanoyl)-3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-2-yl]-N,N-dimethylacetamide
CAS 2411299-82-4C12H18ClN5O3
3-Hydroxy-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine-6-carboxylic acid hydrochloride chemical structure, C6H9ClN4O3, CAS 2408962-31-0
3-Hydroxy-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine-6-carboxylic acid hydrochloride
CAS 2408962-31-0C6H9ClN4O3
7-(2-Chloroacetyl)-2-(2,2-difluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-3-one chemical structure, C9H11ClF2N4O2, CAS 2411295-62-8
7-(2-Chloroacetyl)-2-(2,2-difluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-3-one
CAS 2411295-62-8C9H11ClF2N4O2
2-Methyl-3-oxo-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-sulfonyl fluoride chemical structure, C6H9FN4O3S, CAS 2411254-43-6
2-Methyl-3-oxo-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-sulfonyl fluoride
CAS 2411254-43-6C6H9FN4O3S
2-(3-Fluoro-2-hydroxypropyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-one chemical structure, C8H13FN4O2, CAS 2172589-01-2
2-(3-Fluoro-2-hydroxypropyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-one
CAS 2172589-01-2C8H13FN4O2
7-[(tert-Butoxy)carbonyl]-3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylic acid chemical structure, C11H16N4O5, CAS 2384858-59-5
7-[(tert-Butoxy)carbonyl]-3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylic acid
CAS 2384858-59-5C11H16N4O5
Methyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylate chemical structure, C7H10N4O3, CAS 2168468-66-2
Methyl 3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazine-6-carboxylate
CAS 2168468-66-2C7H10N4O3
3-Oxo-7-[(prop-2-en-1-yloxy)carbonyl]-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid chemical structure, C10H12N4O5, CAS 2680586-08-5
3-Oxo-7-[(prop-2-en-1-yloxy)carbonyl]-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid
CAS 2680586-08-5C10H12N4O5
3-Oxo-7-(2,2,2-trifluoroacetyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid chemical structure, C8H7F3N4O4, CAS 2680621-07-0
3-Oxo-7-(2,2,2-trifluoroacetyl)-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid
CAS 2680621-07-0C8H7F3N4O4