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Murcko scaffold

Ring system with 4 rings and 22 atoms

68 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 68
With full pages: 17

Scaffold SMILES

O=c1sc2ccccc2n1Cc1nncn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1sc2ccccc2n1Cc1nncn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 68 chemicals

2-[[4-(3-Chlorophenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid chemical structure, C18H13ClN4O3S2, CAS 847403-63-8

2-[[4-(3-Chlorophenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid

CAS 847403-63-8C₁₈H₁₃ClN₄O₃S₂

Ethyl 2-[[2-[[4-(2-methylphenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]acetate chemical structure, C23H23N5O4S2, CAS 847402-87-3

Ethyl 2-[[2-[[4-(2-methylphenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]acetate

CAS 847402-87-3C₂₃H₂₃N₅O₄S₂

2-((4-(3-Chlorophenyl)-5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C18H14ClN5O2S2, CAS 847403-47-8

2-((4-(3-Chlorophenyl)-5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 847403-47-8C₁₈H₁₄ClN₅O₂S₂

3-[[4-(3-Chlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one chemical structure, C17H13ClN4OS2, CAS 847403-36-5

3-[[4-(3-Chlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one

CAS 847403-36-5C₁₇H₁₃ClN₄OS₂

Ethyl 2-(2-((5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamido)acetate chemical structure, C22H21N5O4S2, CAS 847402-08-8

Ethyl 2-(2-((5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamido)acetate

CAS 847402-08-8C₂₂H₂₁N₅O₄S₂

3-((5-(Ethylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C19H18N4OS2, CAS 847402-68-0

3-((5-(Ethylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847402-68-0C₁₉H₁₈N₄OS₂

3-((5-(Isopropylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C20H20N4OS2, CAS 847402-70-4

3-((5-(Isopropylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847402-70-4C₂₀H₂₀N₄OS₂

3-[(5-Methylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one chemical structure, C17H14N4OS2, CAS 847400-99-1

3-[(5-Methylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one

CAS 847400-99-1C₁₇H₁₄N₄OS₂

3-[[4-Phenyl-5-(propylthio)-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one chemical structure, C19H18N4OS2, CAS 847401-01-8

3-[[4-Phenyl-5-(propylthio)-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one

CAS 847401-01-8C₁₉H₁₈N₄OS₂

3-((5-(Isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C19H18N4OS2, CAS 847401-02-9

3-((5-(Isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847401-02-9C₁₉H₁₈N₄OS₂

2-((4-(4-Methoxyphenyl)-5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C19H17N5O3S2, CAS 847403-24-1

2-((4-(4-Methoxyphenyl)-5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 847403-24-1C₁₉H₁₇N₅O₃S₂

3-((5-(Methylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C18H16N4OS2, CAS 847402-67-9

3-((5-(Methylthio)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847402-67-9C₁₈H₁₆N₄OS₂

Ethyl 2-[[4-(2-methylphenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C21H20N4O3S2, CAS 847403-06-9

Ethyl 2-[[4-(2-methylphenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate

CAS 847403-06-9C₂₁H₂₀N₄O₃S₂

3-[[4-(4-Methoxyphenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one chemical structure, C18H16N4O2S2, CAS 847403-11-6

3-[[4-(4-Methoxyphenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one

CAS 847403-11-6C₁₈H₁₆N₄O₂S₂

3-[[5-Ethylsulfanyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one chemical structure, C19H18N4O2S2, CAS 847403-12-7

3-[[5-Ethylsulfanyl-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1,3-benzothiazol-2-one

CAS 847403-12-7C₁₉H₁₈N₄O₂S₂

Ethyl 2-((5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)propanoate chemical structure, C21H20N4O3S2, CAS 847402-34-0

Ethyl 2-((5-((2-oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)propanoate

CAS 847402-34-0C₂₁H₂₀N₄O₃S₂

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C19H17N5O2S2, CAS 847402-83-9

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 847402-83-9C₁₉H₁₇N₅O₂S₂

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C18H15N5O2S2, CAS 847401-15-4

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 847401-15-4C₁₈H₁₅N₅O₂S₂

Ethyl 2-[[4-(3-chlorophenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]propanoate chemical structure, C21H19ClN4O3S2, CAS 847403-61-6

Ethyl 2-[[4-(3-chlorophenyl)-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]propanoate

CAS 847403-61-6C₂₁H₁₉ClN₄O₃S₂

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetic acid chemical structure, C19H13F3N4O3S2, CAS 847403-79-6

2-((5-((2-Oxobenzo[d]thiazol-3(2H)-yl)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetic acid

CAS 847403-79-6C₁₉H₁₃F₃N₄O₃S₂

3-[(5-Ethylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one chemical structure, C18H16N4OS2, CAS 847401-00-7

3-[(5-Ethylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one

CAS 847401-00-7C₁₈H₁₆N₄OS₂

3-[(5-Butylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one chemical structure, C20H20N4OS2, CAS 847401-03-0

3-[(5-Butylsulfanyl-4-phenyl-1,2,4-triazol-3-yl)methyl]-1,3-benzothiazol-2-one

CAS 847401-03-0C₂₀H₂₀N₄OS₂

3-((5-(Isopentylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C21H22N4OS2, CAS 847401-05-2

3-((5-(Isopentylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847401-05-2C₂₁H₂₂N₄OS₂

3-((5-(Allylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one chemical structure, C19H16N4OS2, CAS 847401-07-4

3-((5-(Allylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazol-2(3H)-one

CAS 847401-07-4C₁₉H₁₆N₄OS₂