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Murcko scaffold

2-((2-Oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide scaffold

211 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
211
With full pages
13
Scaffold SMILES

O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-((2-Oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide page
Murcko scaffold O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 211 chemicals

2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C18H21N3O2S, CAS 946269-10-9
2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide
CAS 946269-10-9C18H21N3O2S
N-(4-Butylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C19H23N3O2S, CAS 946371-71-7
N-(4-Butylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946371-71-7C19H23N3O2S
N-(3-Fluoro-4-methylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C16H16FN3O2S, CAS 946217-20-5
N-(3-Fluoro-4-methylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946217-20-5C16H16FN3O2S
N-(3,4-Difluorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H13F2N3O2S, CAS 946269-13-2
N-(3,4-Difluorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946269-13-2C15H13F2N3O2S
N-(2-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14N4O4S, CAS 1001612-20-9
N-(2-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 1001612-20-9C15H14N4O4S
N-(3-Methylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C16H17N3O2S, CAS 946217-32-9
N-(3-Methylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946217-32-9C16H17N3O2S
N-(2,3-Dimethylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O2S, CAS 946371-83-1
N-(2,3-Dimethylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946371-83-1C17H19N3O2S
N-(3,5-Dimethylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O2S, CAS 946323-92-8
N-(3,5-Dimethylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946323-92-8C17H19N3O2S
N-Mesityl-2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C18H21N3O2S, CAS 933203-44-2
N-Mesityl-2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
CAS 933203-44-2C18H21N3O2S
2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C16H14F3N3O2S, CAS 946217-40-9
2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 946217-40-9C16H14F3N3O2S
2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]acetamide chemical structure, C16H14F3N3O2S, CAS 1001612-21-0
2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]acetamide
CAS 1001612-21-0C16H14F3N3O2S
N-(3,4-Dimethoxyphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O4S, CAS 946269-33-6
N-(3,4-Dimethoxyphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946269-33-6C17H19N3O4S
N-(4-Ethoxyphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O3S, CAS 946269-37-0
N-(4-Ethoxyphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946269-37-0C17H19N3O3S
N-(3-Acetamidophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H18N4O3S, CAS 1001612-24-3
N-(3-Acetamidophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 1001612-24-3C17H18N4O3S
N-(3-Chlorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14ClN3O2S, CAS 1001612-27-6
N-(3-Chlorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 1001612-27-6C15H14ClN3O2S
N-(4-Chlorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14ClN3O2S, CAS 946371-99-9
N-(4-Chlorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946371-99-9C15H14ClN3O2S
N-(4-Bromophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14BrN3O2S, CAS 1001612-28-7
N-(4-Bromophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 1001612-28-7C15H14BrN3O2S
Ethyl 2-[[2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetyl]amino]benzoate chemical structure, C18H19N3O4S, CAS 946324-09-0
Ethyl 2-[[2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetyl]amino]benzoate
CAS 946324-09-0C18H19N3O4S
N-(4-Acetylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H17N3O3S, CAS 932961-13-2
N-(4-Acetylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 932961-13-2C17H17N3O3S
N-(2,4-Difluorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H13F2N3O2S, CAS 946324-13-6
N-(2,4-Difluorophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946324-13-6C15H13F2N3O2S
N-(4-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14N4O4S, CAS 946269-49-4
N-(4-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946269-49-4C15H14N4O4S
N-(3-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H14N4O4S, CAS 946372-07-2
N-(3-Nitrophenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946372-07-2C15H14N4O4S
N-(3-Acetylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide chemical structure, C17H17N3O3S, CAS 946324-17-0
N-(3-Acetylphenyl)-2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetamide
CAS 946324-17-0C17H17N3O3S
2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-ethylphenyl)acetamide chemical structure, C21H28N4O2S, CAS 898445-22-2
2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-ethylphenyl)acetamide
CAS 898445-22-2C21H28N4O2S