Murcko scaffold
2-((2-Oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide scaffold
211 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 211
- With full pages
- 13
Scaffold SMILES
O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1ccccc1](/scaffold/UDCSGLFPWKYZPA-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 96 of 211 chemicals
![2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-ethylphenyl)acetamide chemical structure, C23H32N4O2S, CAS 898451-63-3](/s/TUMNCFKUIBOPQI-UHFFFAOYSA-N.svg)
2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-ethylphenyl)acetamide
CAS 898451-63-3C23H32N4O2S
![2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide chemical structure, C21H28N4O2S, CAS 898445-62-0](/s/CLMOZASZRWXNOF-UHFFFAOYSA-N.svg)
2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-phenylacetamide
CAS 898445-62-0C21H28N4O2S
![2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2-fluorophenyl)acetamide chemical structure, C21H27FN4O2S, CAS 898451-79-1](/s/URZYHODDHZJOAH-UHFFFAOYSA-N.svg)
2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2-fluorophenyl)acetamide
CAS 898451-79-1C21H27FN4O2S
![2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(o-tolyl)acetamide chemical structure, C22H30N4O2S, CAS 898445-73-3](/s/SCBCCSHOXGWFHM-UHFFFAOYSA-N.svg)
2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(o-tolyl)acetamide
CAS 898445-73-3C22H30N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-ethylphenyl)acetamide chemical structure, C22H30N4O2S, CAS 898434-16-7](/s/KUQYSICWSFBNMJ-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-ethylphenyl)acetamide
CAS 898434-16-7C22H30N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C21H28N4O3S, CAS 898459-88-6](/s/DDBPTVRGECOEMV-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 898459-88-6C21H28N4O3S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-phenylacetamide chemical structure, C20H26N4O2S, CAS 898459-90-0](/s/XEIFKEVXIMYGGK-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-phenylacetamide
CAS 898459-90-0C20H26N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2-fluorophenyl)acetamide chemical structure, C20H25FN4O2S, CAS 898434-30-5](/s/FHOIAJHNLYAOEA-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2-fluorophenyl)acetamide
CAS 898434-30-5C20H25FN4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2-methylphenyl)acetamide chemical structure, C21H28N4O2S, CAS 898459-96-6](/s/IQORKTXEEFXBBL-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2-methylphenyl)acetamide
CAS 898459-96-6C21H28N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-fluorophenyl)acetamide chemical structure, C20H25FN4O2S, CAS 898434-32-7](/s/NTVHYZLFNGNSGX-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-fluorophenyl)acetamide
CAS 898434-32-7C20H25FN4O2S
![N-(3-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C20H25ClN4O2S, CAS 898459-98-8](/s/XCGOUJWMTKZMOX-UHFFFAOYSA-N.svg)
N-(3-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 898459-98-8C20H25ClN4O2S
![N-(4-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C20H25ClN4O2S, CAS 898460-00-9](/s/MRLQMOGTYRVGIW-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 898460-00-9C20H25ClN4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-methylphenyl)acetamide chemical structure, C21H28N4O2S, CAS 898434-37-2](/s/ROIXCMYYQULQSL-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-methylphenyl)acetamide
CAS 898434-37-2C21H28N4O2S
![N-(2,4-Difluorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C20H24F2N4O2S, CAS 898460-07-6](/s/GHVVDZKUXQFFSE-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 898460-07-6C20H24F2N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-methylphenyl)acetamide chemical structure, C21H28N4O2S, CAS 898434-41-8](/s/PLKZYTXQJOGXBB-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(4-methylphenyl)acetamide
CAS 898434-41-8C21H28N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-fluorophenyl)acetamide chemical structure, C20H25FN4O2S, CAS 898460-10-1](/s/FGACLDMJZTXQPK-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-fluorophenyl)acetamide
CAS 898460-10-1C20H25FN4O2S
![2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-isopropylphenyl)acetamide chemical structure, C23H32N4O2S, CAS 898460-12-3](/s/HCJSUKADKVSDPO-UHFFFAOYSA-N.svg)
2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-isopropylphenyl)acetamide
CAS 898460-12-3C23H32N4O2S
![N-(2-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C20H25ClN4O2S, CAS 898460-15-6](/s/ZCSABBDFWJRTQQ-UHFFFAOYSA-N.svg)
N-(2-Chlorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 898460-15-6C20H25ClN4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2,3-dimethylphenyl)acetamide chemical structure, C22H30N4O2S, CAS 933231-03-9](/s/GOPGETNBVFDZCI-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2,3-dimethylphenyl)acetamide
CAS 933231-03-9C22H30N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-fluoro-4-methylphenyl)acetamide chemical structure, C21H27FN4O2S, CAS 946324-89-6](/s/UESPGTQMXALPMB-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3-fluoro-4-methylphenyl)acetamide
CAS 946324-89-6C21H27FN4O2S
![N-(3,4-Difluorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide chemical structure, C20H24F2N4O2S, CAS 898434-48-5](/s/NBTOSTYWBJMCFR-UHFFFAOYSA-N.svg)
N-(3,4-Difluorophenyl)-2-[[1-[3-(dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]acetamide
CAS 898434-48-5C20H24F2N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3,5-dimethylphenyl)acetamide chemical structure, C22H30N4O2S, CAS 898460-19-0](/s/RHJMHVGNGZVGKJ-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(3,5-dimethylphenyl)acetamide
CAS 898460-19-0C22H30N4O2S
![2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2,5-dimethylphenyl)acetamide chemical structure, C22H30N4O2S, CAS 898434-53-2](/s/RQRMBCLTGKJDEA-UHFFFAOYSA-N.svg)
2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2,5-dimethylphenyl)acetamide
CAS 898434-53-2C22H30N4O2S
![2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-mesitylacetamide chemical structure, C23H32N4O2S, CAS 898460-21-4](/s/NJZGWFFPMHYMOZ-UHFFFAOYSA-N.svg)
2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-mesitylacetamide
CAS 898460-21-4C23H32N4O2S
- 2-[[1-[3-(Diethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-phenylacetamide898434-64-5C22H30N4O2S
- 2-[[1-[3-(Diethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(2-methylphenyl)acetamide898460-37-2C23H32N4O2S
- Methyl 4-[[2-[(2-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]acetyl]amino]benzoate898443-92-0C17H17N3O4S
- 2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2,5-dimethylphenyl)acetamide946270-16-2C21H28N4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2,4-dimethylphenyl)acetamide898445-51-7C23H32N4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-fluorophenyl)acetamide898459-51-3C21H27FN4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(p-tolyl)acetamide898459-70-6C22H30N4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(3-fluorophenyl)acetamide898434-09-8C21H27FN4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(3,5-dimethylphenyl)acetamide898434-14-5C23H32N4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2,5-dimethylphenyl)acetamide898459-81-9C23H32N4O2S
- 2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2-methoxyphenyl)acetamide898434-22-5C21H28N4O3S
- 2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(m-tolyl)acetamide898434-81-6C23H32N4O2S
- 2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(p-tolyl)acetamide898460-54-3C23H32N4O2S
- 2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide933204-08-1C22H27F3N4O2S
- 2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide898435-01-3C23H29F3N4O3S
- 2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-mesitylacetamide898435-05-7C25H36N4O2S
- Methyl 4-(2-((1-(2-(diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamido)benzoate898459-56-8C23H30N4O4S
- Ethyl 4-(2-((1-(2-(diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamido)benzoate898459-58-0C24H32N4O4S
- N-(3,5-Bis(trifluoromethyl)phenyl)-2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide898443-89-5C17H13F6N3O2S
- 2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide898451-41-7C20H23F3N4O2S
- 2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide898445-24-4C20H23F3N4O2S
- 2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide898451-43-9C20H23F3N4O2S
- N-(3,4-Dimethoxyphenyl)-2-((1-(2-(dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide898445-27-7C21H28N4O4S
- N-(2,4-Dimethoxyphenyl)-2-((1-(2-(dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide898451-47-3C21H28N4O4S
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