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Murcko scaffold

Ring system with 3 rings and 20 atoms

55 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 55
With full pages: 7

Scaffold SMILES

O=C(CSc1ncnc2sccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1ncnc2sccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-phenylacetamide chemical structure, C16H15N3OS2, CAS 338424-66-1

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-phenylacetamide

CAS 338424-66-1C₁₆H₁₅N₃OS₂

2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-N-(o-tolyl)acetamide chemical structure, C17H17N3OS2, CAS 335217-16-8

2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-N-(o-tolyl)acetamide

CAS 335217-16-8C₁₇H₁₇N₃OS₂

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(2-fluorophenyl)acetamide chemical structure, C16H14FN3OS2, CAS 314260-74-7

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(2-fluorophenyl)acetamide

CAS 314260-74-7C₁₆H₁₄FN₃OS₂

N-(3-Acetylphenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide chemical structure, C18H17N3O2S2, CAS 671200-21-8

N-(3-Acetylphenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide

CAS 671200-21-8C₁₈H₁₇N₃O₂S₂

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide chemical structure, C17H13ClF3N3OS2, CAS 315691-49-7

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide

CAS 315691-49-7C₁₇H₁₃ClF₃N₃OS₂

Ethyl 4-[2-({5,6-dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)acetamido]benzoate chemical structure, C19H19N3O3S2, CAS 315711-12-7

Ethyl 4-[2-({5,6-dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)acetamido]benzoate

CAS 315711-12-7C₁₉H₁₉N₃O₃S₂

N-(3,4-Dimethylphenyl)-2-({5,6-dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)acetamide chemical structure, C18H19N3OS2, CAS 315711-07-0

N-(3,4-Dimethylphenyl)-2-({5,6-dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)acetamide

CAS 315711-07-0C₁₈H₁₉N₃OS₂

2-({5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C17H14F3N3OS2, CAS 335217-20-4

2-({5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl}sulfanyl)-N-[2-(trifluoromethyl)phenyl]acetamide

CAS 335217-20-4C₁₇H₁₄F₃N₃OS₂

Methyl 4-({[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]acetyl}amino)benzoate chemical structure, C18H17N3O3S2, CAS 482635-00-7

Methyl 4-({[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]acetyl}amino)benzoate

CAS 482635-00-7C₁₈H₁₇N₃O₃S₂

2-(5,6-Dimethylthiopheno[3,2-e]pyrimidin-4-ylthio)-N-(2-chlorophenyl)acetamide chemical structure, C16H14ClN3OS2, CAS 338424-85-4

2-(5,6-Dimethylthiopheno[3,2-e]pyrimidin-4-ylthio)-N-(2-chlorophenyl)acetamide

CAS 338424-85-4C₁₆H₁₄ClN₃OS₂

N-(4-Bromophenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide chemical structure, C16H14BrN3OS2, CAS 421578-48-5

N-(4-Bromophenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide

CAS 421578-48-5C₁₆H₁₄BrN₃OS₂

2-(5,6-Dimethylthiopheno[3,2-e]pyrimidin-4-ylthio)-N-(3-chloro-4-fluorophenyl) acetamide chemical structure, C16H13ClFN3OS2, CAS 379243-85-3

2-(5,6-Dimethylthiopheno[3,2-e]pyrimidin-4-ylthio)-N-(3-chloro-4-fluorophenyl) acetamide

CAS 379243-85-3C₁₆H₁₃ClFN₃OS₂

N-(2,6-Difluorophenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide chemical structure, C16H13F2N3OS2, CAS 565427-06-7

N-(2,6-Difluorophenyl)-2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide

CAS 565427-06-7C₁₆H₁₃F₂N₃OS₂

2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(3-methoxyphenyl)acetamide chemical structure, C17H17N3O2S2, CAS 499133-95-8

2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(3-methoxyphenyl)acetamide

CAS 499133-95-8C₁₇H₁₇N₃O₂S₂

N-(4-Bromophenyl)-2-((6-ethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide chemical structure, C16H14BrN3OS2, CAS 421578-44-1

N-(4-Bromophenyl)-2-((6-ethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamide

CAS 421578-44-1C₁₆H₁₄BrN₃OS₂

N-(2,6-Dibromo-4-chlorophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide chemical structure, C16H12Br2ClN3OS2, CAS 496027-72-6

N-(2,6-Dibromo-4-chlorophenyl)-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide

CAS 496027-72-6C₁₆H₁₂Br₂ClN₃OS₂

2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-N-(4-sulfamoylphenyl)acetamide chemical structure, C16H16N4O3S3, CAS 496027-09-9

2-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)thio)-N-(4-sulfamoylphenyl)acetamide

CAS 496027-09-9C₁₆H₁₆N₄O₃S₃

Diethyl 5-(2-(thieno[2,3-d]pyrimidin-4-ylthio)acetamido)isophthalate chemical structure, C20H19N3O5S2, CAS 496027-91-9

Diethyl 5-(2-(thieno[2,3-d]pyrimidin-4-ylthio)acetamido)isophthalate

CAS 496027-91-9C₂₀H₁₉N₃O₅S₂

N-(3-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide chemical structure, C16H14ClN3OS2, CAS 701241-00-1

N-(3-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide

CAS 701241-00-1C₁₆H₁₄ClN₃OS₂

Dimethyl 2-(2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamido)terephthalate chemical structure, C20H19N3O5S2, CAS 670270-73-2

Dimethyl 2-(2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetamido)terephthalate

CAS 670270-73-2C₂₀H₁₉N₃O₅S₂

N-(4-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide chemical structure, C16H14ClN3OS2, CAS 421578-43-0

N-(4-Chlorophenyl)-2-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide

CAS 421578-43-0C₁₆H₁₄ClN₃OS₂

Acetamide, 2-[(6-ethylthieno[2,3-d]pyrimidin-4-yl)thio]-N-(4-methylphenyl)- chemical structure, C17H17N3OS2, CAS 521278-14-8

Acetamide, 2-[(6-ethylthieno[2,3-d]pyrimidin-4-yl)thio]-N-(4-methylphenyl)-

CAS 521278-14-8C₁₇H₁₇N₃OS₂

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(4-methylphenyl)acetamide chemical structure, C17H17N3OS2, CAS 338424-68-3

2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(4-methylphenyl)acetamide

CAS 338424-68-3C₁₇H₁₇N₃OS₂

2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(2-nitrophenyl)acetamide chemical structure, C16H14N4O3S2, CAS 701221-31-0

2-(6-Ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(2-nitrophenyl)acetamide

CAS 701221-31-0C₁₆H₁₄N₄O₃S₂