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Murcko scaffold

N-(2-(6-((2-Oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide scaffold

132 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
31
Chemicals
132
With full pages
13
Scaffold SMILES

O=C(CSc1ccc2nnc(CCNC(=O)c3ccccc3)n2n1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(2-(6-((2-Oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide page
Murcko scaffold O=C(CSc1ccc2nnc(CCNC(=O)c3ccccc3)n2n1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 132 chemicals

N-[2-[6-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]-4-methoxybenzamide chemical structure, C25H26N6O3S, CAS 872995-57-8
N-[2-[6-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]-4-methoxybenzamide
CAS 872995-57-8C25H26N6O3S
4-Methyl-N-(2-(6-((2-oxo-2-(o-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C24H24N6O2S, CAS 872994-59-7
4-Methyl-N-(2-(6-((2-oxo-2-(o-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872994-59-7C24H24N6O2S
N-(2-(6-((2-(Mesitylamino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide chemical structure, C26H28N6O2S, CAS 872994-66-6
N-(2-(6-((2-(Mesitylamino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide
CAS 872994-66-6C26H28N6O2S
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide chemical structure, C25H26N6O2S, CAS 872994-64-4
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide
CAS 872994-64-4C25H26N6O2S
N-(2-(6-((2-(Mesitylamino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C25H26N6O2S, CAS 872993-82-3
N-(2-(6-((2-(Mesitylamino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872993-82-3C25H26N6O2S
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C24H24N6O2S, CAS 872993-80-1
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872993-80-1C24H24N6O2S
N-(2-(6-((2-((3-Acetamidophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C24H23N7O3S, CAS 872994-14-4
N-(2-(6-((2-((3-Acetamidophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872994-14-4C24H23N7O3S
N-(2-(6-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C24H23N7O3S, CAS 872994-15-5
N-(2-(6-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872994-15-5C24H23N7O3S
N-(2-(6-((2-Oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C22H20N6O2S, CAS 872988-33-5
N-(2-(6-((2-Oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872988-33-5C22H20N6O2S
N-(2-(6-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C22H19FN6O2S, CAS 872993-85-6
N-(2-(6-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 872993-85-6C22H19FN6O2S
4-Fluoro-N-(2-(6-((2-oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C22H19FN6O2S, CAS 897758-65-5
4-Fluoro-N-(2-(6-((2-oxo-2-(phenylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 897758-65-5C22H19FN6O2S
4-Fluoro-N-{2-[6-({[(2-methylphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}benzamide chemical structure, C23H21FN6O2S, CAS 897619-59-9
4-Fluoro-N-{2-[6-({[(2-methylphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}benzamide
CAS 897619-59-9C23H21FN6O2S
4-Fluoro-N-(2-(6-((2-oxo-2-(m-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C23H21FN6O2S, CAS 897758-67-7
4-Fluoro-N-(2-(6-((2-oxo-2-(m-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 897758-67-7C23H21FN6O2S
4-Fluoro-N-(2-(6-((2-oxo-2-(p-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C23H21FN6O2S, CAS 897619-61-3
4-Fluoro-N-(2-(6-((2-oxo-2-(p-tolylamino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 897619-61-3C23H21FN6O2S
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide chemical structure, C24H23FN6O2S, CAS 897758-70-2
N-(2-(6-((2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide
CAS 897758-70-2C24H23FN6O2S
N-(2-(6-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide chemical structure, C24H23FN6O2S, CAS 897619-64-6
N-(2-(6-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide
CAS 897619-64-6C24H23FN6O2S
N-(2-(6-((2-((4-Ethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide chemical structure, C24H23FN6O2S, CAS 897619-66-8
N-(2-(6-((2-((4-Ethylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide
CAS 897619-66-8C24H23FN6O2S
4-Fluoro-N-(2-(6-((2-((3-fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C22H18F2N6O2S, CAS 897758-73-5
4-Fluoro-N-(2-(6-((2-((3-fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 897758-73-5C22H18F2N6O2S
4-Fluoro-N-(2-(6-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide chemical structure, C22H18F2N6O2S, CAS 897619-68-0
4-Fluoro-N-(2-(6-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
CAS 897619-68-0C22H18F2N6O2S
N-{2-[6-({[(3-Chlorophenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}-4-fluorobenzamide chemical structure, C22H18ClFN6O2S, CAS 897758-75-7
N-{2-[6-({[(3-Chlorophenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}-4-fluorobenzamide
CAS 897758-75-7C22H18ClFN6O2S
N-(2-(6-((2-((4-Chlorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide chemical structure, C22H18ClFN6O2S, CAS 897619-70-4
N-(2-(6-((2-((4-Chlorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide
CAS 897619-70-4C22H18ClFN6O2S
N-(2-(6-((2-((2,4-Difluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide chemical structure, C22H17F3N6O2S, CAS 897758-76-8
N-(2-(6-((2-((2,4-Difluorophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-fluorobenzamide
CAS 897758-76-8C22H17F3N6O2S
N-{2-[6-({[(3-Chloro-4-methylphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}-4-fluorobenzamide chemical structure, C23H20ClFN6O2S, CAS 897758-78-0
N-{2-[6-({[(3-Chloro-4-methylphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}-4-fluorobenzamide
CAS 897758-78-0C23H20ClFN6O2S
4-Fluoro-N-{2-[6-({[(2-methoxyphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}benzamide chemical structure, C23H21FN6O3S, CAS 897619-72-6
4-Fluoro-N-{2-[6-({[(2-methoxyphenyl)carbamoyl]methyl}sulfanyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}benzamide
CAS 897619-72-6C23H21FN6O3S